Antipsicóticos y suicidio
Fuente:
Redalyc
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Artículo científico |
| Sprache: | es |
| Veröffentlicht: |
Sociedad de Neurología, Psiquiatría y Neurocirugía de Chile
2016
|
| Schlagworte: | |
| Online-Zugang: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1876426453502918656 |
|---|---|
| author | Juan Carlos Martínez-Aguayo |
| author_facet | Juan Carlos Martínez-Aguayo |
| contents | Antipsicóticos y suicidio Juan Carlos Martínez-Aguayo Hernán Silva Marcelo Arancibia Claudia Angulo Eva Madrid Medicina suicide clozapine Antipsychotic schizophrenia The opinions about the relationship between antipsychotics and suicide are controversial due to differences on reported evidence about their specific action. One of the most discussed topics is the increase of depressive symptomatology and the impact of some secondary effects on suicidality, mainly akinesia, akathisia and tardive diskynesia. Another polemical topic is the paradoxical effect due to the decrease of positive symptoms when increasing insight. We performed a critical review of the available literature concerning to the use of antipsychotics in relation to suicide in the context of psychotic and affective disorders. When appraising psychotic disorders, there was no direct evidence to support a reduction in suicide rates when using first-generation antipsychotics, probably due to methodological issues and multifactoriality of the phenomenon. Nevertheless, second-generation antipsychotics could be protective against suicide risk, specifically clozapine, which is considered as an antisuicidal drug on schizophrenic disorders due to a direct antidepressant action and an indirect effect mediated by an improvement in cognitive functions. On the other hand, when appraising affective disorders, bipolar spectrum has demonstrated the greatest use of antipsychotics drugs, showing effectiveness in the management of suicide not greater than mood stabilizers. It becomes essential to identify the specific mechanism of action of antipsychotic drugs to assess their real effect on suicidality. 2016 artículo científico 0034-7388 https://www.redalyc.org/articulo.oa?id=331546792008 es http://www.redalyc.org/revista.oa?id=3315 Revista Chilena de Neuropsiquiatría application/pdf Sociedad de Neurología, Psiquiatría y Neurocirugía de Chile Revista Chilena de Neuropsiquiatría (Chile) Num.2 Vol.54 |
| format | Artículo científico |
| id | redalyc_331546792008 |
| institution | Redalyc |
| language | es |
| publishDate | 2016 |
| publisher | Sociedad de Neurología, Psiquiatría y Neurocirugía de Chile |
| spellingShingle | Antipsicóticos y suicidio Juan Carlos Martínez-Aguayo Medicina suicide clozapine Antipsychotic schizophrenia Antipsicóticos y suicidio Juan Carlos Martínez-Aguayo Hernán Silva Marcelo Arancibia Claudia Angulo Eva Madrid Medicina suicide clozapine Antipsychotic schizophrenia The opinions about the relationship between antipsychotics and suicide are controversial due to differences on reported evidence about their specific action. One of the most discussed topics is the increase of depressive symptomatology and the impact of some secondary effects on suicidality, mainly akinesia, akathisia and tardive diskynesia. Another polemical topic is the paradoxical effect due to the decrease of positive symptoms when increasing insight. We performed a critical review of the available literature concerning to the use of antipsychotics in relation to suicide in the context of psychotic and affective disorders. When appraising psychotic disorders, there was no direct evidence to support a reduction in suicide rates when using first-generation antipsychotics, probably due to methodological issues and multifactoriality of the phenomenon. Nevertheless, second-generation antipsychotics could be protective against suicide risk, specifically clozapine, which is considered as an antisuicidal drug on schizophrenic disorders due to a direct antidepressant action and an indirect effect mediated by an improvement in cognitive functions. On the other hand, when appraising affective disorders, bipolar spectrum has demonstrated the greatest use of antipsychotics drugs, showing effectiveness in the management of suicide not greater than mood stabilizers. It becomes essential to identify the specific mechanism of action of antipsychotic drugs to assess their real effect on suicidality. 2016 artículo científico 0034-7388 https://www.redalyc.org/articulo.oa?id=331546792008 es http://www.redalyc.org/revista.oa?id=3315 Revista Chilena de Neuropsiquiatría application/pdf Sociedad de Neurología, Psiquiatría y Neurocirugía de Chile Revista Chilena de Neuropsiquiatría (Chile) Num.2 Vol.54 |
| title | Antipsicóticos y suicidio |
| topic | Medicina suicide clozapine Antipsychotic schizophrenia |
| url | https://www.redalyc.org/articulo.oa?id=331546792008 |