Neuroprotective actions of 2,4-dinitrophenol. Friend or foe?
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| Natura: | Artículo científico |
| Lingua: | en |
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Associação Neurologia Cognitiva e do Comportamento
2007
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| _version_ | 1876464573425385472 |
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| author | Sergio T. Ferreira |
| author_facet | Sergio T. Ferreira |
| contents | Neuroprotective actions of 2,4-dinitrophenol. Friend or foe? Sergio T. Ferreira Fernanda Guarino De Felice Medicina amyloid therapy β peptide dinitrophenol neuroprotection 2,4-dinitrophenol (DNP) has long been known to be toxic at high concentrations, an effect related to uncoupling of mitochondrial oxidative phosphorylation. Five years ago, however, we reported that low concentrations of DNP protect neurons against the toxicity of the amyloid-β peptide. Since then, a number of other studies have provided evidence of beneficial actions of DNP (at low concentrations), including neuroprotection against different types of insult, blockade of amyloid aggregation, stimulation of neurite outgrowth and neuronal differentiation, and even extension of lifespan in certain organisms. Some of these effects appear due to mild mitochondrial uncoupling and prevention of oxidative stress, whereas other actions are related to activation of additional intracellular signaling pathways. This study discusses the evidence supporting beneficial neuroprotective actions of DNP. DNP and other compounds with similar biological activities may be of interest in the development of novel therapeutic approaches for neurodegenerative diseases and other neurological disorders. 2007 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339529000002 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.4 Vol.1 |
| format | Artículo científico |
| id | redalyc_339529000002 |
| institution | Redalyc |
| language | en |
| publishDate | 2007 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| spellingShingle | Neuroprotective actions of 2,4-dinitrophenol. Friend or foe? Sergio T. Ferreira Medicina amyloid therapy β peptide dinitrophenol neuroprotection Neuroprotective actions of 2,4-dinitrophenol. Friend or foe? Sergio T. Ferreira Fernanda Guarino De Felice Medicina amyloid therapy β peptide dinitrophenol neuroprotection 2,4-dinitrophenol (DNP) has long been known to be toxic at high concentrations, an effect related to uncoupling of mitochondrial oxidative phosphorylation. Five years ago, however, we reported that low concentrations of DNP protect neurons against the toxicity of the amyloid-β peptide. Since then, a number of other studies have provided evidence of beneficial actions of DNP (at low concentrations), including neuroprotection against different types of insult, blockade of amyloid aggregation, stimulation of neurite outgrowth and neuronal differentiation, and even extension of lifespan in certain organisms. Some of these effects appear due to mild mitochondrial uncoupling and prevention of oxidative stress, whereas other actions are related to activation of additional intracellular signaling pathways. This study discusses the evidence supporting beneficial neuroprotective actions of DNP. DNP and other compounds with similar biological activities may be of interest in the development of novel therapeutic approaches for neurodegenerative diseases and other neurological disorders. 2007 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339529000002 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.4 Vol.1 |
| title | Neuroprotective actions of 2,4-dinitrophenol. Friend or foe? |
| topic | Medicina amyloid therapy β peptide dinitrophenol neuroprotection |
| url | https://www.redalyc.org/articulo.oa?id=339529000002 |