Argyrophilic grain disease. An update on a frequent cause of dementia
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| Format: | Artículo científico |
| Sprache: | en |
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Associação Neurologia Cognitiva e do Comportamento
2009
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| _version_ | 1876448766359240704 |
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| author | Lea T. Grinberg |
| author_facet | Lea T. Grinberg |
| contents | Argyrophilic grain disease. An update on a frequent cause of dementia Lea T. Grinberg Helmut Heinsen Medicina tau brain Pathology neurology argyrophilic grain disease Argyrophilic grain disease (AGD) is a sporadic, very late-onset tauopathy, accounting for aproximately 4–13% of neurodegenerative dementias. AGD may manifest with a range of symptoms such as cognitive decline and behavioral abnormalities. To date, no study has been able to demonstrate a distinct clinical syndrome associated with AGD. The diagnosis is exclusively based on postmortem findings, the significance of which remains controversial because up to 30% of AGD cases are diagnosed in subjects without any cognitive impairment, while AGD findings often overlap with those of other neurodegenerative processes. Nevertheless, the presence of AGD is likely to have a significant effect on cognitive decline. The neuropathological hallmarks of AGD are argyrophilic grains, pre-neurofibrillary tangles in neurons and coiled bodies in oligodendrocytes found mainly in the entorhinal cortex and hippocampus. This review aims to provide an up-to-date overview of AGD, emphasizing pathological aspects. Additionally, the findings of a Brazilian case series are described. 2009 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339529012002 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.1 Vol.3 |
| format | Artículo científico |
| id | redalyc_339529012002 |
| institution | Redalyc |
| language | en |
| publishDate | 2009 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| spellingShingle | Argyrophilic grain disease. An update on a frequent cause of dementia Lea T. Grinberg Medicina tau brain Pathology neurology argyrophilic grain disease Argyrophilic grain disease. An update on a frequent cause of dementia Lea T. Grinberg Helmut Heinsen Medicina tau brain Pathology neurology argyrophilic grain disease Argyrophilic grain disease (AGD) is a sporadic, very late-onset tauopathy, accounting for aproximately 4–13% of neurodegenerative dementias. AGD may manifest with a range of symptoms such as cognitive decline and behavioral abnormalities. To date, no study has been able to demonstrate a distinct clinical syndrome associated with AGD. The diagnosis is exclusively based on postmortem findings, the significance of which remains controversial because up to 30% of AGD cases are diagnosed in subjects without any cognitive impairment, while AGD findings often overlap with those of other neurodegenerative processes. Nevertheless, the presence of AGD is likely to have a significant effect on cognitive decline. The neuropathological hallmarks of AGD are argyrophilic grains, pre-neurofibrillary tangles in neurons and coiled bodies in oligodendrocytes found mainly in the entorhinal cortex and hippocampus. This review aims to provide an up-to-date overview of AGD, emphasizing pathological aspects. Additionally, the findings of a Brazilian case series are described. 2009 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339529012002 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.1 Vol.3 |
| title | Argyrophilic grain disease. An update on a frequent cause of dementia |
| topic | Medicina tau brain Pathology neurology argyrophilic grain disease |
| url | https://www.redalyc.org/articulo.oa?id=339529012002 |