Stroke and brain atrophy in chronic Chagas disease patients. A new theory proposition
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Associação Neurologia Cognitiva e do Comportamento
2009
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| _version_ | 1876484244422787072 |
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| author | Jamary Oliveira Filho |
| author_facet | Jamary Oliveira Filho |
| contents | Stroke and brain atrophy in chronic Chagas disease patients. A new theory proposition Jamary Oliveira Filho Medicina cognition pathogenesis Chagas disease American trypanosomiasis cerebrovascular disorders Chagas disease (CD) remains a major cause of cardiomyopathy and stroke in developing countries. Brain damage in CD has been attributed exclusively to the effects of structural heart disease on the brain, including cardioembolism and low cardiac output symptoms. However, CD patients also develop stroke and brain atrophy independently of cardiac disease severity. Chronic inflammation directed against T. cruzi may act as a trigger for endothelial damage, platelet activation, acceleration of atherosclerosis and apoptosis, all of which lead to stroke and brain atrophy. In the present article, evidence supporting this new theory is presented, along with considerations towards mechanistically-based targeted treatment. 2009 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339529012005 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.1 Vol.3 |
| format | Artículo científico |
| id | redalyc_339529012005 |
| institution | Redalyc |
| language | en |
| publishDate | 2009 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| spellingShingle | Stroke and brain atrophy in chronic Chagas disease patients. A new theory proposition Jamary Oliveira Filho Medicina cognition pathogenesis Chagas disease American trypanosomiasis cerebrovascular disorders Stroke and brain atrophy in chronic Chagas disease patients. A new theory proposition Jamary Oliveira Filho Medicina cognition pathogenesis Chagas disease American trypanosomiasis cerebrovascular disorders Chagas disease (CD) remains a major cause of cardiomyopathy and stroke in developing countries. Brain damage in CD has been attributed exclusively to the effects of structural heart disease on the brain, including cardioembolism and low cardiac output symptoms. However, CD patients also develop stroke and brain atrophy independently of cardiac disease severity. Chronic inflammation directed against T. cruzi may act as a trigger for endothelial damage, platelet activation, acceleration of atherosclerosis and apoptosis, all of which lead to stroke and brain atrophy. In the present article, evidence supporting this new theory is presented, along with considerations towards mechanistically-based targeted treatment. 2009 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339529012005 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.1 Vol.3 |
| title | Stroke and brain atrophy in chronic Chagas disease patients. A new theory proposition |
| topic | Medicina cognition pathogenesis Chagas disease American trypanosomiasis cerebrovascular disorders |
| url | https://www.redalyc.org/articulo.oa?id=339529012005 |