The influence of neuropsychiatric and functional changes on quality of life in Alzheimer’s disease
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| Format: | Artículo científico |
| Langue: | en |
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Associação Neurologia Cognitiva e do Comportamento
2010
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| _version_ | 1876462517255929856 |
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| author | Marcia M.P.C. Novelli |
| author_facet | Marcia M.P.C. Novelli |
| contents | The influence of neuropsychiatric and functional changes on quality of life in Alzheimer’s disease Marcia M.P.C. Novelli Paulo Caramelli Medicina caregivers Quality of life Alzheimer’s disease functional performance neuropsychiatric symptoms To investigate the influence of neuropsychiatric manifestations and functional performance on quality of life (QOL) of AD patients and their caregivers/family members. Methods: The QOL-AD scale, Mini-Mental State Examination (MMSE), Geriatric Depression Scale (GDS), Cornell and Beck Scales for Depression, Physical and Instrumental-Self Maintenance scales (AIDL and ADL) and the Neuropsychiatric Inventory (NPI) were applied to 60 patients with probable AD, mild (n=30) or moderate (n=30) dementia, according to NINCDS-ADRDA and DSM-III-R criteria, respectively, and to their caregivers/family members. The total scores on the three QOL-AD versions were correlated with the measures previously mentioned. Results: The QOL-AD patients’ version displayed significant correlations with GDS (–0.76 p<0.01), Cornell (–0.53 p<0.01) and NPI (–0.46 p<0.05) in the mild dementia subgroup. The caregivers’ version about patients’ QOL correlated with GDS (–0.48 p<0.01), Cornell (–0.57 p<0.01), NPI (–0.46 p<0.01) and AIDL (–0.36 p<0.05), while the caregivers’ version about their own QOL was significantly correlated with NPI (–0.43 p<0.01), AIDL (–0.35 p<0.05) and Beck Depression (–0.67 p<0.01). In the moderate dementia subgroup, significant correlations were observed with GDS (–0.45 p<0.05) and Cornell (–0.46 p<0.01). For the caregivers’ version about patients’ QOL, significant correlations emerged with Cornell (–0.68 p<0.01), NPI (–0.67 p<0.01), AIDL (–0.41 p<0.05), ADL (–0.49, p<0.01) and Beck Depression (–0.33 p<0.05). For the caregivers’ version about their own QOL, significant correlations with Beck Depression (–0.54 p<0.01) and ADL (–0.38, p<0.05) were found. Conclusion: The symptoms presented in AD affected the QOL in patients and caregivers/family members in both mild and moderate dementia. 2010 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339529016014 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.1 Vol.4 |
| format | Artículo científico |
| id | redalyc_339529016014 |
| institution | Redalyc |
| language | en |
| publishDate | 2010 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| spellingShingle | The influence of neuropsychiatric and functional changes on quality of life in Alzheimer’s disease Marcia M.P.C. Novelli Medicina caregivers Quality of life Alzheimer’s disease functional performance neuropsychiatric symptoms The influence of neuropsychiatric and functional changes on quality of life in Alzheimer’s disease Marcia M.P.C. Novelli Paulo Caramelli Medicina caregivers Quality of life Alzheimer’s disease functional performance neuropsychiatric symptoms To investigate the influence of neuropsychiatric manifestations and functional performance on quality of life (QOL) of AD patients and their caregivers/family members. Methods: The QOL-AD scale, Mini-Mental State Examination (MMSE), Geriatric Depression Scale (GDS), Cornell and Beck Scales for Depression, Physical and Instrumental-Self Maintenance scales (AIDL and ADL) and the Neuropsychiatric Inventory (NPI) were applied to 60 patients with probable AD, mild (n=30) or moderate (n=30) dementia, according to NINCDS-ADRDA and DSM-III-R criteria, respectively, and to their caregivers/family members. The total scores on the three QOL-AD versions were correlated with the measures previously mentioned. Results: The QOL-AD patients’ version displayed significant correlations with GDS (–0.76 p<0.01), Cornell (–0.53 p<0.01) and NPI (–0.46 p<0.05) in the mild dementia subgroup. The caregivers’ version about patients’ QOL correlated with GDS (–0.48 p<0.01), Cornell (–0.57 p<0.01), NPI (–0.46 p<0.01) and AIDL (–0.36 p<0.05), while the caregivers’ version about their own QOL was significantly correlated with NPI (–0.43 p<0.01), AIDL (–0.35 p<0.05) and Beck Depression (–0.67 p<0.01). In the moderate dementia subgroup, significant correlations were observed with GDS (–0.45 p<0.05) and Cornell (–0.46 p<0.01). For the caregivers’ version about patients’ QOL, significant correlations emerged with Cornell (–0.68 p<0.01), NPI (–0.67 p<0.01), AIDL (–0.41 p<0.05), ADL (–0.49, p<0.01) and Beck Depression (–0.33 p<0.05). For the caregivers’ version about their own QOL, significant correlations with Beck Depression (–0.54 p<0.01) and ADL (–0.38, p<0.05) were found. Conclusion: The symptoms presented in AD affected the QOL in patients and caregivers/family members in both mild and moderate dementia. 2010 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339529016014 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.1 Vol.4 |
| title | The influence of neuropsychiatric and functional changes on quality of life in Alzheimer’s disease |
| topic | Medicina caregivers Quality of life Alzheimer’s disease functional performance neuropsychiatric symptoms |
| url | https://www.redalyc.org/articulo.oa?id=339529016014 |