Morphometric brain changes during aging. Results from a Brazilian necropsy sample
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| Natura: | Artículo científico |
| Lingua: | en |
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Associação Neurologia Cognitiva e do Comportamento
2010
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| _version_ | 1876455589685493760 |
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| author | Renata Eloah de Lucena Ferretti |
| author_facet | Renata Eloah de Lucena Ferretti |
| contents | Morphometric brain changes during aging. Results from a Brazilian necropsy sample Renata Eloah de Lucena Ferretti Wilson Jacob-Filho Lea Tenenholz Grinberg Renata Elaine Paraízo Leite José Marcelo Farfel Claudia Kimie Suemoto Paulo Hilário Nascimento Saldiva Sérgio Rosemberg Carlos Augusto Pasqualucci Ricardo Nitrini Medicina aging brain anatomy cephalometry The present study aimed to establish the morphometric brain changes during aging in a necropsy series from Brazil and determine whether sexual dimorphisms interfere in these changes. Methods: A crosssectional study was conducted at the São Paulo Autopsy Servicein Brazil where, after informed consent, data was gathered from next of kin interview withreference to clinical status prior to death. Brain weight, volume and density measurementswere taken and then adjusted for head circumference. Descriptive statistics and testsof hypothesis and correlations were applied, considering a p-value of 0.05. Results: 414subjects, mostly men (60.4%), with a mean age of 67.1 years, were included. The mean brain weight of the sample was 1219.2g±140.9 and mean volume was 1217mL±152.3. The mean brain density of the sample was 1.0g/mL±0.09. Values differed between males and females in terms of weight and volume. Brain weight decreased during aging by about 45g per decade (r= –0.300; p<0.01) and volume by about 43mL (r= –0.278; p<0.00). Meandensity of the sample was 1.0 g/mL in both genders. Conclusions: Brain weight and volume (with or without corrections) decreased during aging, and these reductions were more pronounced in women. Density remained unchanged for both genders. Further studies are needed to investigate factors associated to these reductions. 2010 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339529019013 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.4 Vol.4 |
| format | Artículo científico |
| id | redalyc_339529019013 |
| institution | Redalyc |
| language | en |
| publishDate | 2010 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| spellingShingle | Morphometric brain changes during aging. Results from a Brazilian necropsy sample Renata Eloah de Lucena Ferretti Medicina aging brain anatomy cephalometry Morphometric brain changes during aging. Results from a Brazilian necropsy sample Renata Eloah de Lucena Ferretti Wilson Jacob-Filho Lea Tenenholz Grinberg Renata Elaine Paraízo Leite José Marcelo Farfel Claudia Kimie Suemoto Paulo Hilário Nascimento Saldiva Sérgio Rosemberg Carlos Augusto Pasqualucci Ricardo Nitrini Medicina aging brain anatomy cephalometry The present study aimed to establish the morphometric brain changes during aging in a necropsy series from Brazil and determine whether sexual dimorphisms interfere in these changes. Methods: A crosssectional study was conducted at the São Paulo Autopsy Servicein Brazil where, after informed consent, data was gathered from next of kin interview withreference to clinical status prior to death. Brain weight, volume and density measurementswere taken and then adjusted for head circumference. Descriptive statistics and testsof hypothesis and correlations were applied, considering a p-value of 0.05. Results: 414subjects, mostly men (60.4%), with a mean age of 67.1 years, were included. The mean brain weight of the sample was 1219.2g±140.9 and mean volume was 1217mL±152.3. The mean brain density of the sample was 1.0g/mL±0.09. Values differed between males and females in terms of weight and volume. Brain weight decreased during aging by about 45g per decade (r= –0.300; p<0.01) and volume by about 43mL (r= –0.278; p<0.00). Meandensity of the sample was 1.0 g/mL in both genders. Conclusions: Brain weight and volume (with or without corrections) decreased during aging, and these reductions were more pronounced in women. Density remained unchanged for both genders. Further studies are needed to investigate factors associated to these reductions. 2010 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339529019013 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.4 Vol.4 |
| title | Morphometric brain changes during aging. Results from a Brazilian necropsy sample |
| topic | Medicina aging brain anatomy cephalometry |
| url | https://www.redalyc.org/articulo.oa?id=339529019013 |