Behavioural-variant frontotemporal dementia. An update
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| Natura: | Artículo científico |
| Lingua: | en |
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Associação Neurologia Cognitiva e do Comportamento
2013
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| _version_ | 1876491414800433152 |
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| author | Olivier Piguet |
| author_facet | Olivier Piguet |
| contents | Behavioural-variant frontotemporal dementia. An update Olivier Piguet John R. Hodges Medicina genetics cognition neuroimaging social cognition frontotemporal dementia Behavioral - variant frontotemporal dementia (bvFTD) is characterised by insidious changes in personality and interpersonal conduct that reflect progressive disintegration of the neural circuits involved in social cognition, emotion regulation, motivation and decision making. The underlying pathology is heterogeneous and classified according to the presence of intraneuronal inclusions of tau, TDP-43 or occasionally FUS. Biomarkers to detect these histopathological changes in life are increasingly important with the development of disease-modifying drugs. Gene mutations have been found which collectively account for around 10-20% of cases including a novel hexanucleotide repeat on chromosome 9 (C9orf72). The recently reviewed International Consensus Criteria for bvFTD propose three levels of diagnostic certainly: possible, probable and definite. Detailed history taking from family members to elicit behavioural features underpins the diagnostic process with support from neuropsychological testing designed to detect impairment in decision-making, emotion processing and social cognition. Brain imaging is important for increasing the level of diagnosis certainty. Carer education and support remain of paramount importance. 2013 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339529042003 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.1 Vol.7 |
| format | Artículo científico |
| id | redalyc_339529042003 |
| institution | Redalyc |
| language | en |
| publishDate | 2013 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| spellingShingle | Behavioural-variant frontotemporal dementia. An update Olivier Piguet Medicina genetics cognition neuroimaging social cognition frontotemporal dementia Behavioural-variant frontotemporal dementia. An update Olivier Piguet John R. Hodges Medicina genetics cognition neuroimaging social cognition frontotemporal dementia Behavioral - variant frontotemporal dementia (bvFTD) is characterised by insidious changes in personality and interpersonal conduct that reflect progressive disintegration of the neural circuits involved in social cognition, emotion regulation, motivation and decision making. The underlying pathology is heterogeneous and classified according to the presence of intraneuronal inclusions of tau, TDP-43 or occasionally FUS. Biomarkers to detect these histopathological changes in life are increasingly important with the development of disease-modifying drugs. Gene mutations have been found which collectively account for around 10-20% of cases including a novel hexanucleotide repeat on chromosome 9 (C9orf72). The recently reviewed International Consensus Criteria for bvFTD propose three levels of diagnostic certainly: possible, probable and definite. Detailed history taking from family members to elicit behavioural features underpins the diagnostic process with support from neuropsychological testing designed to detect impairment in decision-making, emotion processing and social cognition. Brain imaging is important for increasing the level of diagnosis certainty. Carer education and support remain of paramount importance. 2013 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339529042003 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.1 Vol.7 |
| title | Behavioural-variant frontotemporal dementia. An update |
| topic | Medicina genetics cognition neuroimaging social cognition frontotemporal dementia |
| url | https://www.redalyc.org/articulo.oa?id=339529042003 |