Frontal presentation of Alzheimer’s disease. A series of patients with biological evidence by CSF biomarkers
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| Format: | Artículo científico |
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Associação Neurologia Cognitiva e do Comportamento
2013
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| _version_ | 1876428398241251328 |
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| author | Leonardo Cruz de Souza |
| author_facet | Leonardo Cruz de Souza |
| contents | Frontal presentation of Alzheimer’s disease. A series of patients with biological evidence by CSF biomarkers Leonardo Cruz de Souza Maxime Bertoux Aurélie Funkiewiez Dalila Samri Carole Azuar Marie Odile Habert Aurélie Kas Foudil Lamari Marie Sarazin Bruno Dubois Medicina striatum striatum Alzheimer’s disease Alzheimer’s disease frontotemporal dementia Behavioural disturbances in frontotemporal dementia (FTD) are thought to reflect mainly atrophy of cortical regions. Recent studies suggest that subcortical brain regions, in particular the striatum, are also significantly affected and this pathology might play a role in the generation of behavioural symptoms. Objective: To investigate prefrontal cortical and striatal atrophy contributions to behavioural symptoms in FTD. Methods: One hundred and eighty-two participants (87 FTD patients, 39 AD patients and 56 controls) were included. Behavioural profiles were established using the Cambridge Behavioural Inventory Revised (CBI-R) and Frontal System Behaviour Scale (FrSBe). Atrophy in prefrontal (VMPFC, DLPFC) and striatal (caudate, putamen) regions was established via a 5-point visual rating scale of the MRI scans. Behavioural scores were correlated with atrophy rating scores. Results: Behavioural and atrophy ratings demonstrated that patients were significantly impaired compared to controls, with bvFTD being most severely affected. Behavioural-anatomical correlations revealed that VMPFC atrophy was closely related to abnormal behaviour and motivation disturbances. Stereotypical behaviours were associated with both VMPFC and striatal atrophy. By contrast, disturbance of eating was found to be related to striatal atrophy only. Conclusion: Frontal and striatal atrophy contributed to the behavioural disturbances seen in FTD, with some behaviours related to frontal, striatal or combined fronto-striatal pathology. Consideration of striatal contributions to the generation of behavioural disturbances should be taken into account when assessing patients with potential FTD. 2013 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339529042011 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.1 Vol.7 |
| format | Artículo científico |
| id | redalyc_339529042011 |
| institution | Redalyc |
| language | en |
| publishDate | 2013 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| spellingShingle | Frontal presentation of Alzheimer’s disease. A series of patients with biological evidence by CSF biomarkers Leonardo Cruz de Souza Medicina striatum striatum Alzheimer’s disease Alzheimer’s disease frontotemporal dementia Frontal presentation of Alzheimer’s disease. A series of patients with biological evidence by CSF biomarkers Leonardo Cruz de Souza Maxime Bertoux Aurélie Funkiewiez Dalila Samri Carole Azuar Marie Odile Habert Aurélie Kas Foudil Lamari Marie Sarazin Bruno Dubois Medicina striatum striatum Alzheimer’s disease Alzheimer’s disease frontotemporal dementia Behavioural disturbances in frontotemporal dementia (FTD) are thought to reflect mainly atrophy of cortical regions. Recent studies suggest that subcortical brain regions, in particular the striatum, are also significantly affected and this pathology might play a role in the generation of behavioural symptoms. Objective: To investigate prefrontal cortical and striatal atrophy contributions to behavioural symptoms in FTD. Methods: One hundred and eighty-two participants (87 FTD patients, 39 AD patients and 56 controls) were included. Behavioural profiles were established using the Cambridge Behavioural Inventory Revised (CBI-R) and Frontal System Behaviour Scale (FrSBe). Atrophy in prefrontal (VMPFC, DLPFC) and striatal (caudate, putamen) regions was established via a 5-point visual rating scale of the MRI scans. Behavioural scores were correlated with atrophy rating scores. Results: Behavioural and atrophy ratings demonstrated that patients were significantly impaired compared to controls, with bvFTD being most severely affected. Behavioural-anatomical correlations revealed that VMPFC atrophy was closely related to abnormal behaviour and motivation disturbances. Stereotypical behaviours were associated with both VMPFC and striatal atrophy. By contrast, disturbance of eating was found to be related to striatal atrophy only. Conclusion: Frontal and striatal atrophy contributed to the behavioural disturbances seen in FTD, with some behaviours related to frontal, striatal or combined fronto-striatal pathology. Consideration of striatal contributions to the generation of behavioural disturbances should be taken into account when assessing patients with potential FTD. 2013 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339529042011 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.1 Vol.7 |
| title | Frontal presentation of Alzheimer’s disease. A series of patients with biological evidence by CSF biomarkers |
| topic | Medicina striatum striatum Alzheimer’s disease Alzheimer’s disease frontotemporal dementia |
| url | https://www.redalyc.org/articulo.oa?id=339529042011 |