Argyrophilic grain disease. An underestimated tauopathy
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| Format: | Artículo científico |
| Language: | en |
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Associação Neurologia Cognitiva e do Comportamento
2015
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| _version_ | 1876485356479578112 |
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| author | Roberta Diehl Rodriguez |
| author_facet | Roberta Diehl Rodriguez |
| contents | Argyrophilic grain disease. An underestimated tauopathy Roberta Diehl Rodriguez Lea Tenenholz Grinberg Medicina dementia pathology postmortem tauopathies Argyrophilic grain disease Argyrophilic grain disease (AGD) is an under-recognized, distinct, highly frequent sporadic tauopathy, with a prevalence reaching 31.3% in centenarians. The most common AGD manifestation is slowly progressive amnestic mild cognitive impairment, accompanied by a high prevalence of neuropsychiatric symptoms. AGD diagnosis can only be achieved postmortem based on the finding of its three main pathologic features: argyrophilic grains, oligodendrocytic coiled bodies and neuronal pretangles. AGD is frequently seen together with Alzheimer’s disease-type pathology or in association with other neurodegenerative diseases. Recent studies suggest that AGD may be a defense mechanism against the spread of other neuropathological entities, particularly Alzheimer’s disease. This review aims to provide an in-depth overview of the current understanding on AGD. 2015 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339538469002 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.1 Vol.9 |
| format | Artículo científico |
| id | redalyc_339538469002 |
| institution | Redalyc |
| language | en |
| publishDate | 2015 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| spellingShingle | Argyrophilic grain disease. An underestimated tauopathy Roberta Diehl Rodriguez Medicina dementia pathology postmortem tauopathies Argyrophilic grain disease Argyrophilic grain disease. An underestimated tauopathy Roberta Diehl Rodriguez Lea Tenenholz Grinberg Medicina dementia pathology postmortem tauopathies Argyrophilic grain disease Argyrophilic grain disease (AGD) is an under-recognized, distinct, highly frequent sporadic tauopathy, with a prevalence reaching 31.3% in centenarians. The most common AGD manifestation is slowly progressive amnestic mild cognitive impairment, accompanied by a high prevalence of neuropsychiatric symptoms. AGD diagnosis can only be achieved postmortem based on the finding of its three main pathologic features: argyrophilic grains, oligodendrocytic coiled bodies and neuronal pretangles. AGD is frequently seen together with Alzheimer’s disease-type pathology or in association with other neurodegenerative diseases. Recent studies suggest that AGD may be a defense mechanism against the spread of other neuropathological entities, particularly Alzheimer’s disease. This review aims to provide an in-depth overview of the current understanding on AGD. 2015 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339538469002 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.1 Vol.9 |
| title | Argyrophilic grain disease. An underestimated tauopathy |
| topic | Medicina dementia pathology postmortem tauopathies Argyrophilic grain disease |
| url | https://www.redalyc.org/articulo.oa?id=339538469002 |