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| Format: | Artículo científico |
| Language: | en |
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Associação Neurologia Cognitiva e do Comportamento
2015
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| Online Access: | https://www.redalyc.org/articulo.oa?id=339538469002 |
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Table of Contents:
- Argyrophilic grain disease. An underestimated tauopathy Roberta Diehl Rodriguez Lea Tenenholz Grinberg Medicina dementia pathology postmortem tauopathies Argyrophilic grain disease Argyrophilic grain disease (AGD) is an under-recognized, distinct, highly frequent sporadic tauopathy, with a prevalence reaching 31.3% in centenarians. The most common AGD manifestation is slowly progressive amnestic mild cognitive impairment, accompanied by a high prevalence of neuropsychiatric symptoms. AGD diagnosis can only be achieved postmortem based on the finding of its three main pathologic features: argyrophilic grains, oligodendrocytic coiled bodies and neuronal pretangles. AGD is frequently seen together with Alzheimer’s disease-type pathology or in association with other neurodegenerative diseases. Recent studies suggest that AGD may be a defense mechanism against the spread of other neuropathological entities, particularly Alzheimer’s disease. This review aims to provide an in-depth overview of the current understanding on AGD. 2015 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339538469002 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.1 Vol.9