Type 2 diabetes mellitus in the pathophysiology of Alzheimer’s disease
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| Format: | Artículo científico |
| Sprache: | en |
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Associação Neurologia Cognitiva e do Comportamento
2017
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| author | Aparecida Marcelino de Nazareth |
| author_facet | Aparecida Marcelino de Nazareth |
| contents | Type 2 diabetes mellitus in the pathophysiology of Alzheimer’s disease Aparecida Marcelino de Nazareth Medicina inflammation Alzheimer’s disease type 2 diabetes mellitus Both Alzheimer’s disease (AD) and type 2 diabetes mellitus (DM) are two common forms of disease worldwide and many studies indicate that people with diabetes, especially DM, are at higher risk of developing AD. AD is characterized by progressive cognitive decline and accumulation of β-amyloid (Aβ) forming senile plaques. DM is a metabolic disorder characterized by hyperglycemia in the context of insulin resistance and relative lack of insulin. Both diseases also share common characteristics such as loss of cognitive function and inflammation. Inflammation resulting from Aβ further induces production of Aβ1-42 peptides. Inflammation due to overnutrition induces insulin resistance and consequently DM. Memory deficit and a decrease in GLUT4 and hippocampal insulin signaling have been observed in animal models of insulin resistance. The objective of this review was to show the shared characteristics of AD and DM. 2017 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339551660002 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.2 Vol.11 |
| format | Artículo científico |
| id | redalyc_339551660002 |
| institution | Redalyc |
| language | en |
| publishDate | 2017 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| spellingShingle | Type 2 diabetes mellitus in the pathophysiology of Alzheimer’s disease Aparecida Marcelino de Nazareth Medicina inflammation Alzheimer’s disease type 2 diabetes mellitus Type 2 diabetes mellitus in the pathophysiology of Alzheimer’s disease Aparecida Marcelino de Nazareth Medicina inflammation Alzheimer’s disease type 2 diabetes mellitus Both Alzheimer’s disease (AD) and type 2 diabetes mellitus (DM) are two common forms of disease worldwide and many studies indicate that people with diabetes, especially DM, are at higher risk of developing AD. AD is characterized by progressive cognitive decline and accumulation of β-amyloid (Aβ) forming senile plaques. DM is a metabolic disorder characterized by hyperglycemia in the context of insulin resistance and relative lack of insulin. Both diseases also share common characteristics such as loss of cognitive function and inflammation. Inflammation resulting from Aβ further induces production of Aβ1-42 peptides. Inflammation due to overnutrition induces insulin resistance and consequently DM. Memory deficit and a decrease in GLUT4 and hippocampal insulin signaling have been observed in animal models of insulin resistance. The objective of this review was to show the shared characteristics of AD and DM. 2017 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339551660002 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.2 Vol.11 |
| title | Type 2 diabetes mellitus in the pathophysiology of Alzheimer’s disease |
| topic | Medicina inflammation Alzheimer’s disease type 2 diabetes mellitus |
| url | https://www.redalyc.org/articulo.oa?id=339551660002 |