Association between diabetes and causes of dementia. Evidence from a clinicopathological study
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| Format: | Artículo científico |
| Langue: | en |
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Associação Neurologia Cognitiva e do Comportamento
2017
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| _version_ | 1876482089681944576 |
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| author | Maria Niures Pimentel dos Santos Matioli |
| author_facet | Maria Niures Pimentel dos Santos Matioli |
| contents | Association between diabetes and causes of dementia. Evidence from a clinicopathological study Maria Niures Pimentel dos Santos Matioli Claudia Kimie Suemoto Roberta Diehl Rodriguez Daniela Souza Farias Magnólia Moreira da Silva Renata Elaine Paraizo Leite Renata Eloah Lucena Ferretti-Rebustini Carlos Augusto Pasqualucci Wilson Jacob Filho Lea Tenenholz Grinberg Ricardo Nitrini Medicina neuropathology Diabetes mellitus vascular dementia Alzheimer’s disease clinicopathologic study Diabetes mellitus is a risk factor for dementia, especially for vascular dementia (VaD), but there is no consensus on diabetes as a risk factor for Alzheimer’s disease (AD) and other causes of dementia. Objective: To explore the association between diabetes and the neuropathological etiology of dementia in a large autopsy study. Methods: Data were collected from the participants of the Brain Bank of the Brazilian Aging Brain Study Group between 2004 and 2015. Diagnosis of diabetes was reported by the deceased’s next-of-kin. Clinical dementia was established when CDR ≥ 1 and IQCODE > 3.41. Dementia etiology was determined by neuropathological examination using immunohistochemistry. The association of diabetes with odds of dementia was investigated using multivariate logistic regression. Results: We included 1,037 subjects and diabetes was present in 279 participants (27%). The prevalence of dementia diagnosis was similar in diabetics (29%) and non-diabetics (27%). We found no association between diabetes and dementia (OR = 1.22; 95%CI = 0.81-1.82; p = 0.34) on the multivariate analysis. AD was the main cause of dementia in both groups, while VaD was the second-most-frequent cause in diabetics. Other mixed dementia was the second-most-common cause of dementia and more frequent among non-diabetics (p = 0.03). Conclusion: Diabetes was not associated with dementia in this large clinicopathological study. 2017 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339554592010 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.4 Vol.11 |
| format | Artículo científico |
| id | redalyc_339554592010 |
| institution | Redalyc |
| language | en |
| publishDate | 2017 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| spellingShingle | Association between diabetes and causes of dementia. Evidence from a clinicopathological study Maria Niures Pimentel dos Santos Matioli Medicina neuropathology Diabetes mellitus vascular dementia Alzheimer’s disease clinicopathologic study Association between diabetes and causes of dementia. Evidence from a clinicopathological study Maria Niures Pimentel dos Santos Matioli Claudia Kimie Suemoto Roberta Diehl Rodriguez Daniela Souza Farias Magnólia Moreira da Silva Renata Elaine Paraizo Leite Renata Eloah Lucena Ferretti-Rebustini Carlos Augusto Pasqualucci Wilson Jacob Filho Lea Tenenholz Grinberg Ricardo Nitrini Medicina neuropathology Diabetes mellitus vascular dementia Alzheimer’s disease clinicopathologic study Diabetes mellitus is a risk factor for dementia, especially for vascular dementia (VaD), but there is no consensus on diabetes as a risk factor for Alzheimer’s disease (AD) and other causes of dementia. Objective: To explore the association between diabetes and the neuropathological etiology of dementia in a large autopsy study. Methods: Data were collected from the participants of the Brain Bank of the Brazilian Aging Brain Study Group between 2004 and 2015. Diagnosis of diabetes was reported by the deceased’s next-of-kin. Clinical dementia was established when CDR ≥ 1 and IQCODE > 3.41. Dementia etiology was determined by neuropathological examination using immunohistochemistry. The association of diabetes with odds of dementia was investigated using multivariate logistic regression. Results: We included 1,037 subjects and diabetes was present in 279 participants (27%). The prevalence of dementia diagnosis was similar in diabetics (29%) and non-diabetics (27%). We found no association between diabetes and dementia (OR = 1.22; 95%CI = 0.81-1.82; p = 0.34) on the multivariate analysis. AD was the main cause of dementia in both groups, while VaD was the second-most-frequent cause in diabetics. Other mixed dementia was the second-most-common cause of dementia and more frequent among non-diabetics (p = 0.03). Conclusion: Diabetes was not associated with dementia in this large clinicopathological study. 2017 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339554592010 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.4 Vol.11 |
| title | Association between diabetes and causes of dementia. Evidence from a clinicopathological study |
| topic | Medicina neuropathology Diabetes mellitus vascular dementia Alzheimer’s disease clinicopathologic study |
| url | https://www.redalyc.org/articulo.oa?id=339554592010 |