Increased CSF levels of total Tau in patients with subcortical cerebrovascular pathology and cognitive impairment
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Associação Neurologia Cognitiva e do Comportamento
2017
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| _version_ | 1876433720048615424 |
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| author | Márcia Radanovic |
| author_facet | Márcia Radanovic |
| contents | Increased CSF levels of total Tau in patients with subcortical cerebrovascular pathology and cognitive impairment Márcia Radanovic Florindo Stella Lis Gomes Silva Leda L. Talib Orestes V. Forlenza Medicina amyloid tau protein subcortical vascular lesions Vascular cognitive impairment cerebrospinal fluid biomarkers Cognitive impairment includes mild cognitive decline and dementia, such as Alzheimer’s disease (AD) and cerebrovascular-related pathologies. Objective: To investigate the profile of AD-related CSF biomarkers in a sample of cognitively impaired and unimpaired older adults with concomitant subcortical cerebrovascular burden. Methods: Seventy-eight older adults attending an outpatient psychogeriatric clinic were enrolled. Diagnoses were based on clinical, neuropsychological, laboratory, and neuroimaging data. Participants were classified into: cognitively normal (controls, n = 30), mild cognitive impairment (MCI, n = 34), and dementia (AD, n = 14). All subjects were submitted to CSF analyses for determination of amyloid-beta (A β 1-42 ), total tau (t-tau), phosphorylated tau (p-tau) and A β 1-42 /p-tau ratio according to the Luminex method. MRI was performed in all individuals, and was scored independently by two experts according to Fazekas scale. Statistical analyses were conducted with the aid of general linear model procedures, and the Chi-squared test. Results: T-tau levels were significantly associated with subcortical lesion pattern when Fazekas was considered as a group factor. CSF biomarkers were not associated with MCI, AD, or controls when considered separately. There was a tendency for reduction in CSF A β 1-42 together with increasing Fazekas scores, but without statistical significance. Comparisons of A β 1-42 and t-tau with each clinical group or with each neuroimaging pattern did not reach statistical differences. Likewise, Fazekas scores had no impact on CAMCOG scores. Conclusion: We found a significant association between t-tau levels and subcortical lesions when all Fazekas classifications were considered as a single group; comparisons of Fazekas subgroups and CSF biomarkers did not reach significance. 2017 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339554592012 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.4 Vol.11 |
| format | Artículo científico |
| id | redalyc_339554592012 |
| institution | Redalyc |
| language | en |
| publishDate | 2017 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| spellingShingle | Increased CSF levels of total Tau in patients with subcortical cerebrovascular pathology and cognitive impairment Márcia Radanovic Medicina amyloid tau protein subcortical vascular lesions Vascular cognitive impairment cerebrospinal fluid biomarkers Increased CSF levels of total Tau in patients with subcortical cerebrovascular pathology and cognitive impairment Márcia Radanovic Florindo Stella Lis Gomes Silva Leda L. Talib Orestes V. Forlenza Medicina amyloid tau protein subcortical vascular lesions Vascular cognitive impairment cerebrospinal fluid biomarkers Cognitive impairment includes mild cognitive decline and dementia, such as Alzheimer’s disease (AD) and cerebrovascular-related pathologies. Objective: To investigate the profile of AD-related CSF biomarkers in a sample of cognitively impaired and unimpaired older adults with concomitant subcortical cerebrovascular burden. Methods: Seventy-eight older adults attending an outpatient psychogeriatric clinic were enrolled. Diagnoses were based on clinical, neuropsychological, laboratory, and neuroimaging data. Participants were classified into: cognitively normal (controls, n = 30), mild cognitive impairment (MCI, n = 34), and dementia (AD, n = 14). All subjects were submitted to CSF analyses for determination of amyloid-beta (A β 1-42 ), total tau (t-tau), phosphorylated tau (p-tau) and A β 1-42 /p-tau ratio according to the Luminex method. MRI was performed in all individuals, and was scored independently by two experts according to Fazekas scale. Statistical analyses were conducted with the aid of general linear model procedures, and the Chi-squared test. Results: T-tau levels were significantly associated with subcortical lesion pattern when Fazekas was considered as a group factor. CSF biomarkers were not associated with MCI, AD, or controls when considered separately. There was a tendency for reduction in CSF A β 1-42 together with increasing Fazekas scores, but without statistical significance. Comparisons of A β 1-42 and t-tau with each clinical group or with each neuroimaging pattern did not reach statistical differences. Likewise, Fazekas scores had no impact on CAMCOG scores. Conclusion: We found a significant association between t-tau levels and subcortical lesions when all Fazekas classifications were considered as a single group; comparisons of Fazekas subgroups and CSF biomarkers did not reach significance. 2017 artículo científico 1980-5764 https://www.redalyc.org/articulo.oa?id=339554592012 en http://www.redalyc.org/revista.oa?id=3395 Dementia & Neuropsychologia application/pdf Associação Neurologia Cognitiva e do Comportamento Dementia & Neuropsychologia (Brasil) Num.4 Vol.11 |
| title | Increased CSF levels of total Tau in patients with subcortical cerebrovascular pathology and cognitive impairment |
| topic | Medicina amyloid tau protein subcortical vascular lesions Vascular cognitive impairment cerebrospinal fluid biomarkers |
| url | https://www.redalyc.org/articulo.oa?id=339554592012 |