What are the reasons for the repeated failures of clinical trials with anti-amyloid drugs for AD treatment?
Fuente:
Redalyc
Enregistré dans:
| Auteur principal: | Orestes Vicente Forlenza |
|---|---|
| Format: | Artículo científico |
| Langue: | en |
| Publié: |
Associação Neurologia Cognitiva e do Comportamento
2025
|
| Sujets: | |
| Accès en ligne: | |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
Subtherapeutic dose lithium treatment induces behavioral and neuropathological changes in 3xTg‐AD Alzheimer's mice
par: Monique Patricio Singulani, et autres
Publié: (2025)
par: Monique Patricio Singulani, et autres
Publié: (2025)
Dose‐Dependent Effects of Lithium on Biological Pathways, Ribosomes, Mitochondria, and Proteasomes in Hippocampal Neurons: Insights from Gene and Protein Expression
par: Orestes Vicente Forlenza, et autres
Publié: (2025)
par: Orestes Vicente Forlenza, et autres
Publié: (2025)
Phosphatidylcholine as a potential AD‐related biomarker in Down syndrome, but not in Alzheimer's disease patients: Preliminary findings
par: Bruna Berribilli Bortoleto, et autres
Publié: (2025)
par: Bruna Berribilli Bortoleto, et autres
Publié: (2025)
Evaluating amyloid-beta as a surrogate endpoint in trials of anti-amyloid drugs in Alzheimer's disease: a Bayesian meta-analysis
par: Ren, Sa, et autres
Publié: (2025)
par: Ren, Sa, et autres
Publié: (2025)
What are the recommended first-line anti-resorptive drugs for the treatment of osteoporosis according to the latest clinical guidelines?
par: Tripdatabase
Publié: (2026)
par: Tripdatabase
Publié: (2026)
Tacrolimus treatment in women with repeated implantation failures
par: Koji Nakagawa, et autres
Publié: (2024)
par: Koji Nakagawa, et autres
Publié: (2024)
“Real‐world” eligibility for anti‐amyloid treatment in a tertiary memory clinic setting
par: Sinthujah Vigneswaran, et autres
Publié: (2025)
par: Sinthujah Vigneswaran, et autres
Publié: (2025)
‘Real‐world’ eligibility for anti‐amyloid treatment in a tertiary memory clinic setting
par: Sinthujah Vigneswaran, et autres
Publié: (2025)
par: Sinthujah Vigneswaran, et autres
Publié: (2025)
DETECT‐AD ‐ Digital Evaluations and Technologies Enabling Clinical Translation for Alzheimer’s Disease: Results of amyloid screening methodologies in a simulated anti‐amyloid clinical trial using digital biomarkers as primary outcome measures
par: Jeffrey A Kaye, et autres
Publié: (2024)
par: Jeffrey A Kaye, et autres
Publié: (2024)
Effect of amyloid, tau and syndromic stages of Alzheimer's disease (AD) in speech markers: A potential scalable tool for screening in AD clinical trials
par: Srinivasan Vairavan, et autres
Publié: (2025)
par: Srinivasan Vairavan, et autres
Publié: (2025)
BACE1 expression in neurodegenerative and neurodevelopmental diseases
par: Leda Leme Talib, et autres
Publié: (2024)
par: Leda Leme Talib, et autres
Publié: (2024)
Phospolipase D Insights: Elevated Levels in Mild Cognitive Impairment, Therapeutic Reduction in Alzheimer's Patients
par: Cícero Augusto Costa Pereira, et autres
Publié: (2024)
par: Cícero Augusto Costa Pereira, et autres
Publié: (2024)
Role of ‘‘health-related quality of life’’ measurements in the design of drug clinical trials
par: R. San Miguel
Publié: (2010)
par: R. San Miguel
Publié: (2010)
The Alzheimer’s Tau Platform (ATP): a Phase 2, combination amyloid and tau therapy clinical trial for early AD
par: Adam L. Boxer, et autres
Publié: (2024)
par: Adam L. Boxer, et autres
Publié: (2024)
Fe de errores de «Role of «health-reated quality of life» measurements in the design of drug clinical trials»
par:
Publié: (2011)
par:
Publié: (2011)
The benefits of hypnosis as an adjunct treatment for bronchial asthma-a clinical trial
par: Yaimarelis Picó Carela
Publié: (2024)
par: Yaimarelis Picó Carela
Publié: (2024)
WMH and AD: is CAA the missing piece? Potential consequences at the anti‐amyloid era
par: Andreas Charidimou
Publié: (2024)
par: Andreas Charidimou
Publié: (2024)
Lithium as a pharmacological approach to treat behavioral complications in Alzheimer’s disease: a preclinical study
par: Monique Patricio Singulani, et autres
Publié: (2024)
par: Monique Patricio Singulani, et autres
Publié: (2024)
Long-term randomized clinical trials of pharmacological treatment of obesity: Systematic review
par: LIDIA CASTAÑEDA-GONZÁLEZ
Publié: (2010)
par: LIDIA CASTAÑEDA-GONZÁLEZ
Publié: (2010)
Non-invasive ventilation in the treatment of acute and chronic exacerbated respiratory failure: What to expect outside the critical care units?
par: M.E. Brandão
Publié: (2016)
par: M.E. Brandão
Publié: (2016)
Demographic representation in Phase III clinical trials of anti‐amyloid therapy for Alzheimer’s disease: a cross‐sectional analysis
par: Justine Tin Nok Chan, et autres
Publié: (2025)
par: Justine Tin Nok Chan, et autres
Publié: (2025)
Reasons for screening failure in the evoke and evoke+ trials of semaglutide for early AD
par: Mary Sano, et autres
Publié: (2024)
par: Mary Sano, et autres
Publié: (2024)
Inflammatory modulation and cellular stress response to lithium treatment in the hippocampus of Alzheimer's disease
par: Carlos Wagner Leal Cordeiro Júnior, et autres
Publié: (2025)
par: Carlos Wagner Leal Cordeiro Júnior, et autres
Publié: (2025)
Frequency, characteristics, and reasons for termination of cerebral palsy clinical trials
par: Michael J. Gouzoulis, et autres
Publié: (2025)
par: Michael J. Gouzoulis, et autres
Publié: (2025)
Determining eligibility for anti‐amyloid treatments using blood biomarkers
par: Suzanne E. Schindler, et autres
Publié: (2025)
par: Suzanne E. Schindler, et autres
Publié: (2025)
Randomized clinical trial of a postdischarge pharmaceutical care program vs. regular follow-up in patients with heart failure
par: C. López Cabezas
Publié: (2006)
par: C. López Cabezas
Publié: (2006)
Long-term clinical effects of aspirin-desensitization therapy among patients with poorly controlled asthma and non-steroidal anti-inflammatory drug hypersensitivity: An exploratory study
par: U. Förster-Ruhrmann
Publié: (2015)
par: U. Förster-Ruhrmann
Publié: (2015)
Assessing amyloid PET positivity and cognitive function in Down syndrome to guide clinical trials targeting amyloid
par: Sophia Krasny, et autres
Publié: (2024)
par: Sophia Krasny, et autres
Publié: (2024)
Relationship between drug interactions and drug-related negative clinical outcomes
par: Javier CREMADES
Publié: (2009)
par: Javier CREMADES
Publié: (2009)
Disclosure of elevated amyloid status is not associated with long‐term suicidality in a preclinical AD trial
par: Joshua D. Grill, et autres
Publié: (2025)
par: Joshua D. Grill, et autres
Publié: (2025)
Double blind clinical trial of lemborexant for AD prevention: Protocol for a randomized controlled clinical trial
par: Nolan‐Patrick Cunningham, et autres
Publié: (2025)
par: Nolan‐Patrick Cunningham, et autres
Publié: (2025)
Off-label prescription of drugs at hospital
par: Vicente Arocas Casañ
Publié: (2016)
par: Vicente Arocas Casañ
Publié: (2016)
Eligibility for anti‐amyloid treatment in a multiethnic community‐based study
par: Lydia Trudel, et autres
Publié: (2026)
par: Lydia Trudel, et autres
Publié: (2026)
Visual rating of the medial temporal lobe atrophy on magnetic resonance imaging in elderly patients with type I bipolar disorder
par: Rodolfo Braga Ladeira, et autres
Publié: (2025)
par: Rodolfo Braga Ladeira, et autres
Publié: (2025)
Principal Component Analysis discriminates lipid metabolites in the plasma of individuals with MCI, Alzheimer's, and Down Syndrome
par: Tamires Alves Sarno, et autres
Publié: (2024)
par: Tamires Alves Sarno, et autres
Publié: (2024)
The script clinical reasoning test An internal medicine educational practice perspective
par: TATIANA ECHEVERRY-DÍAZ
Publié: (2023)
par: TATIANA ECHEVERRY-DÍAZ
Publié: (2023)
Dientes cariados, obturados y perdidos en pacientes con diabetes mellitus y sin ella
par: Orestes D. Rodríguez Arias
Publié: (2006)
par: Orestes D. Rodríguez Arias
Publié: (2006)
Hiperparatiroidismo en su forma ósea
par: Orestes Dominador Rodríguez Arias
Publié: (2008)
par: Orestes Dominador Rodríguez Arias
Publié: (2008)
Lack of transparency in clinical trials: a call for action
par: Jorge H. Ramírez
Publié: (2013)
par: Jorge H. Ramírez
Publié: (2013)
Delta‐like ligand 4 inhibitor drug treatment induces pulmonary hypertension in cancer clinical trials
par: Casandra E. Besse, et autres
Publié: (2024)
par: Casandra E. Besse, et autres
Publié: (2024)
Documents similaires
-
Subtherapeutic dose lithium treatment induces behavioral and neuropathological changes in 3xTg‐AD Alzheimer's mice
par: Monique Patricio Singulani, et autres
Publié: (2025) -
Dose‐Dependent Effects of Lithium on Biological Pathways, Ribosomes, Mitochondria, and Proteasomes in Hippocampal Neurons: Insights from Gene and Protein Expression
par: Orestes Vicente Forlenza, et autres
Publié: (2025) -
Phosphatidylcholine as a potential AD‐related biomarker in Down syndrome, but not in Alzheimer's disease patients: Preliminary findings
par: Bruna Berribilli Bortoleto, et autres
Publié: (2025) -
Evaluating amyloid-beta as a surrogate endpoint in trials of anti-amyloid drugs in Alzheimer's disease: a Bayesian meta-analysis
par: Ren, Sa, et autres
Publié: (2025) -
What are the recommended first-line anti-resorptive drugs for the treatment of osteoporosis according to the latest clinical guidelines?
par: Tripdatabase
Publié: (2026)