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| Format: | Artículo científico |
| Language: | en |
| Published: |
Instituto Tecnológico Metropolitano
2017
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| Subjects: | |
| Online Access: | https://www.redalyc.org/articulo.oa?id=344253674009 https://www.redalyc.org/journal/3442/344253674009/ https://www.redalyc.org/journal/3442/344253674009/html/ https://www.redalyc.org/journal/3442/344253674009/344253674009.epub https://www.redalyc.org/journal/3442/344253674009/movil |
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| _version_ | 1866814853890441216 |
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| author | Diana C. Pachajoa |
| author_facet | Diana C. Pachajoa |
| contents | CO, Pb++ and SO2 effects on L-type calcium channel and action potential in human atrial myocytes. In silico study Diana C. Pachajoa Catalina Tobón Juan P. Ugarte Javier Saiz Ingeniería Air pollution calcium channel in silico models atrial action potential Exposure to air pollutants like carbon monoxide (CO), lead (Pb ++ ) and sulfur dioxide (SO 2 ) promotes the occurrence of cardiovascular diseases. Experimental studies have shown that CO, Pb ++ and SO 2 block L - type calcium channels, re ducing the calcium current (I CaL ) and the action potential duration (APD), which favors the initiation of atrial arrhythmias. The goal is to study the effects of CO, Pb ++ and SO 2 at different concentrations on I CaL and act ion potential using computational simulation. For this purpose, models of the effects of the air pollutants on the atrial L - type calcium channel were developed and were incorporated into a mathematical model of a human atrial cell. The results suggest that CO, Pb ++ and SO 2 block the I CaL current in a fraction that increases along with the concentration, generating an APD shortening. These results are consistent with experimental studies. The combined effect of the three air pollutants produced an APD shorte ning, which is considered to be a pro - arrhythmic effect. 2017 artículo científico 0123-7799 https://www.redalyc.org/articulo.oa?id=344253674009 https://www.redalyc.org/journal/3442/344253674009/ https://www.redalyc.org/journal/3442/344253674009/html/ https://www.redalyc.org/journal/3442/344253674009/344253674009.epub https://www.redalyc.org/journal/3442/344253674009/movil en http://www.redalyc.org/revista.oa?id=3442 TecnoLógicas application/pdf Instituto Tecnológico Metropolitano TecnoLógicas (Colombia) Num.40 Vol.20 |
| format | Artículo científico |
| id | redalyc_344253674009 |
| language | en |
| publishDate | 2017 |
| publisher | Instituto Tecnológico Metropolitano |
| spellingShingle | CO, Pb++ and SO2 effects on L-type calcium channel and action potential in human atrial myocytes. In silico study Diana C. Pachajoa Ingeniería Air pollution calcium channel in silico models atrial action potential CO, Pb++ and SO2 effects on L-type calcium channel and action potential in human atrial myocytes. In silico study Diana C. Pachajoa Catalina Tobón Juan P. Ugarte Javier Saiz Ingeniería Air pollution calcium channel in silico models atrial action potential Exposure to air pollutants like carbon monoxide (CO), lead (Pb ++ ) and sulfur dioxide (SO 2 ) promotes the occurrence of cardiovascular diseases. Experimental studies have shown that CO, Pb ++ and SO 2 block L - type calcium channels, re ducing the calcium current (I CaL ) and the action potential duration (APD), which favors the initiation of atrial arrhythmias. The goal is to study the effects of CO, Pb ++ and SO 2 at different concentrations on I CaL and act ion potential using computational simulation. For this purpose, models of the effects of the air pollutants on the atrial L - type calcium channel were developed and were incorporated into a mathematical model of a human atrial cell. The results suggest that CO, Pb ++ and SO 2 block the I CaL current in a fraction that increases along with the concentration, generating an APD shortening. These results are consistent with experimental studies. The combined effect of the three air pollutants produced an APD shorte ning, which is considered to be a pro - arrhythmic effect. 2017 artículo científico 0123-7799 https://www.redalyc.org/articulo.oa?id=344253674009 https://www.redalyc.org/journal/3442/344253674009/ https://www.redalyc.org/journal/3442/344253674009/html/ https://www.redalyc.org/journal/3442/344253674009/344253674009.epub https://www.redalyc.org/journal/3442/344253674009/movil en http://www.redalyc.org/revista.oa?id=3442 TecnoLógicas application/pdf Instituto Tecnológico Metropolitano TecnoLógicas (Colombia) Num.40 Vol.20 |
| title | CO, Pb++ and SO2 effects on L-type calcium channel and action potential in human atrial myocytes. In silico study |
| topic | Ingeniería Air pollution calcium channel in silico models atrial action potential |
| url | https://www.redalyc.org/articulo.oa?id=344253674009 https://www.redalyc.org/journal/3442/344253674009/ https://www.redalyc.org/journal/3442/344253674009/html/ https://www.redalyc.org/journal/3442/344253674009/344253674009.epub https://www.redalyc.org/journal/3442/344253674009/movil |