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| Autore principale: | |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Sociedad Española de Farmacia Hospitalaria
2013
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| Soggetti: | |
| Accesso online: | https://www.redalyc.org/articulo.oa?id=365961316004 |
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Sommario:
- Extemporaneous clobazam suspensions for paediatric use prepared from commercially available tablets and pure drug F Buontempo M. A. Moretton E Quiroga D. A. Chiappetta Medicina Clobazam Epilepsy Stability Antiepileptic drugs Paediatric oral suspension Objective: Two clobazam aqueous suspensions for paediatric oral usage (5 mg/ml) were investigated to determinate its physicochemical stability under different storage conditions. Method: Formulations were stored at 4 and 25 ºC and the clobazam content was determined by High Performance Liquid Chromatography. Each sample was analyzed by triplicate at different time points (0, 7, 14, 28 and 56 days). Results: Liquid suspensions were successfully formulated from pure drug and commercially available tablets. In both cases, samples showed suitable physical stability. Clobazam was chemically stable in aqueous suspension during the 56 days of the study at the two storage temperatures. Conclusions: All the tried oral liquid formulations can be conserved at 4 and 25 ºC at least 56-day period. 2013 artículo científico 1130-6343 https://www.redalyc.org/articulo.oa?id=365961316004 en http://www.redalyc.org/revista.oa?id=3659 Farmacia Hospitalaria application/pdf Sociedad Española de Farmacia Hospitalaria Farmacia Hospitalaria (España) Num.2 Vol.37