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| Formato: | Artículo científico |
| Lenguaje: | en |
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Sociedad Española de Farmacia Hospitalaria
2010
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| Acceso en línea: | https://www.redalyc.org/articulo.oa?id=365961369005 |
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- Carvedilol stability in paediatric oral liquid formulations F. Buontempo E. Bernabeu R.J. Glisoni E. Quiroga C. Bregni D.A. Chiappetta Medicina Beta Stability Carvedilol Paediatric oral solution adrenergic blocking agent Objective: Two carvedilol aqueous solutions and one carvedilol aqueous suspension for paediatric oral use (1 mg/ml) were studied to determine their stability. Method: All samples were stored at 4, 25 and 401 C. Carvedilol content of each of the three formulations was tested using high performance liquid chromatography (HPLC). Each sample was analysed in triplicate at 0, 3, 7, 14, 28 and 56 days. Results: Carvedilol stayed stable in the acidic aqueous solution at the three different temperatures during the 56 days of the study. In the alkaline solution, carvedilol was stable during 56 days at 251 C, but only 28 days at 4 and 401 C. In the aqueous suspension, carvedilol was stable during 56 days at 4 and 251 C, but only 28 days at 401 C. Conclusions: All the formulations that were tested can be stored at 251 C for at least 56 days. 2010 artículo científico 1130-6343 https://www.redalyc.org/articulo.oa?id=365961369005 en http://www.redalyc.org/revista.oa?id=3659 Farmacia Hospitalaria application/pdf Sociedad Española de Farmacia Hospitalaria Farmacia Hospitalaria (España) Num.6 Vol.34