Physicochemical characterization of micafungin and anidulafungin for its nebulized administration
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| Format: | Artículo científico |
| Sprache: | en |
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Sociedad Española de Farmacia Hospitalaria
2019
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| _version_ | 1876487043190620160 |
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| author | Laura Gómez-Ganda |
| author_facet | Laura Gómez-Ganda |
| contents | Physicochemical characterization of micafungin and anidulafungin for its nebulized administration Laura Gómez-Ganda Sonia Terradas-Campanario David Campany-Herrero Medicina Nebulized Micafungin Antifungal Scedosporium Anidulafungin Objective: To determine by experimentation whether micafungin and anidulafungin possess physicochemical properties suitable for nebulization. Method: PH, osmolality, viscosity, density and chloride content were determined by pH monitoring, osmometry, viscometry, densitometry and potentiometry in two samples of different concentrations, 5 and 10 mg/mL each echinocandin.Results: The results obtained for micafungin solution were: pH 5.80 (0.14), osmolality 293.33 (1.53) mOsm/kg, chloride content 134.67 (0.58) mmol/L and density 1,009.4 (0,1) kg/m3; while for 10 mg/mL solution: osmolality 342.00 (1.00) mOsm/kg, chloride content 139.67 (0.58) mmol/L and density 1,014.5 (0.2) kg/m3. The results obtained for 5 mg/mL anidulafungin were: pH 4.22 (0.01), osmolality 464.67 (2.52) mOsm/kg, chloride content 137.00 (0.00) mmol/L and density 1,016.5 (0,2) kg/m3; while for 10 mg/mL solution: osmolality 656.33 (1.15) mOsm/kg, chloride content 132.00 (0.00) mmol/L and density 1,029.8 (0.4) kg/m3.Conclusions: PH, osmolality, chloride content and density values proved to be suitable for proper tolerability by nebulization. 2019 artículo científico 1130-6343 https://www.redalyc.org/articulo.oa?id=365961518005 https://www.redalyc.org/journal/3659/365961518005/ https://www.redalyc.org/journal/3659/365961518005/html/ https://www.redalyc.org/journal/3659/365961518005/365961518005.epub https://www.redalyc.org/journal/3659/365961518005/movil 10.7399/fh.11226 en http://www.redalyc.org/revista.oa?id=3659 Farmacia Hospitalaria application/pdf Sociedad Española de Farmacia Hospitalaria Farmacia Hospitalaria (España) Num.5 Vol.43 |
| format | Artículo científico |
| id | redalyc_365961518005 |
| institution | Redalyc |
| language | en |
| publishDate | 2019 |
| publisher | Sociedad Española de Farmacia Hospitalaria |
| spellingShingle | Physicochemical characterization of micafungin and anidulafungin for its nebulized administration Laura Gómez-Ganda Medicina Nebulized Micafungin Antifungal Scedosporium Anidulafungin Physicochemical characterization of micafungin and anidulafungin for its nebulized administration Laura Gómez-Ganda Sonia Terradas-Campanario David Campany-Herrero Medicina Nebulized Micafungin Antifungal Scedosporium Anidulafungin Objective: To determine by experimentation whether micafungin and anidulafungin possess physicochemical properties suitable for nebulization. Method: PH, osmolality, viscosity, density and chloride content were determined by pH monitoring, osmometry, viscometry, densitometry and potentiometry in two samples of different concentrations, 5 and 10 mg/mL each echinocandin.Results: The results obtained for micafungin solution were: pH 5.80 (0.14), osmolality 293.33 (1.53) mOsm/kg, chloride content 134.67 (0.58) mmol/L and density 1,009.4 (0,1) kg/m3; while for 10 mg/mL solution: osmolality 342.00 (1.00) mOsm/kg, chloride content 139.67 (0.58) mmol/L and density 1,014.5 (0.2) kg/m3. The results obtained for 5 mg/mL anidulafungin were: pH 4.22 (0.01), osmolality 464.67 (2.52) mOsm/kg, chloride content 137.00 (0.00) mmol/L and density 1,016.5 (0,2) kg/m3; while for 10 mg/mL solution: osmolality 656.33 (1.15) mOsm/kg, chloride content 132.00 (0.00) mmol/L and density 1,029.8 (0.4) kg/m3.Conclusions: PH, osmolality, chloride content and density values proved to be suitable for proper tolerability by nebulization. 2019 artículo científico 1130-6343 https://www.redalyc.org/articulo.oa?id=365961518005 https://www.redalyc.org/journal/3659/365961518005/ https://www.redalyc.org/journal/3659/365961518005/html/ https://www.redalyc.org/journal/3659/365961518005/365961518005.epub https://www.redalyc.org/journal/3659/365961518005/movil 10.7399/fh.11226 en http://www.redalyc.org/revista.oa?id=3659 Farmacia Hospitalaria application/pdf Sociedad Española de Farmacia Hospitalaria Farmacia Hospitalaria (España) Num.5 Vol.43 |
| title | Physicochemical characterization of micafungin and anidulafungin for its nebulized administration |
| topic | Medicina Nebulized Micafungin Antifungal Scedosporium Anidulafungin |
| url | https://www.redalyc.org/articulo.oa?id=365961518005 https://www.redalyc.org/journal/3659/365961518005/ https://www.redalyc.org/journal/3659/365961518005/html/ https://www.redalyc.org/journal/3659/365961518005/365961518005.epub https://www.redalyc.org/journal/3659/365961518005/movil |