Pharmacogenetic analysis of the absorption kinetics of cyclosporine in a population of Spanish cardiac transplant patients
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| Format: | Artículo científico |
| Language: | en |
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Sociedad Española de Farmacia Hospitalaria
2009
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| _version_ | 1876424375668834304 |
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| author | B. Isla Tejera |
| author_facet | B. Isla Tejera |
| contents | Pharmacogenetic analysis of the absorption kinetics of cyclosporine in a population of Spanish cardiac transplant patients B. Isla Tejera M.D. Aumente Rubio J. Martínez-Moreno M. Reyes Malia J.M. Arizón A. Suárez García Medicina Cyclosporine Pharmacogenetics Pharmacokinetics Cardiac transplant Objective: To determine how single nucleotide polymorphisms located on genes MDR1, CYP3A4, and CYP3A5 affect the absorption kinetics of cyclosporine in cardiac transplant patients. Method: We selected a sample of 30 adult patients having previously undergone a primary cardiac transplant and who had received cyclosporine as an immunosuppressant. During the Àrst month after the transplant, we performed a pharmacokinetic study of each patient to determine values in the cyclosporine concentration area under the 12-hour curve, steady-state cyclosporine concentration, maximum cyclosporine concentration, and time to reach that concentration. Single nucleotide polymorphisms were genotyped in all patients: MDR1 3435C > T, CYP3A4-390A > G, and CYP3A5 6986A > G. Results: Being a carrier of the T-allele for polymorphism MDR1 3435C > T is associated with higher values in the cyclosporine concentration area under the 12-hour curve (P=.01) and in steady-state cyclosporine concentration (P=.05), compared with those from patients who do not carry that allele. Discussion: Our results show that genotype differences in MDR1 3435C > T can explain part of the variability in cyclosporine absorption among individuals in the population of Spanish cardiac transplant recipients. 2009 artículo científico 1130-6343 https://www.redalyc.org/articulo.oa?id=365961793005 en http://www.redalyc.org/revista.oa?id=3659 Farmacia Hospitalaria application/pdf Sociedad Española de Farmacia Hospitalaria Farmacia Hospitalaria (España) Num.6 Vol.33 |
| format | Artículo científico |
| id | redalyc_365961793005 |
| institution | Redalyc |
| language | en |
| publishDate | 2009 |
| publisher | Sociedad Española de Farmacia Hospitalaria |
| spellingShingle | Pharmacogenetic analysis of the absorption kinetics of cyclosporine in a population of Spanish cardiac transplant patients B. Isla Tejera Medicina Cyclosporine Pharmacogenetics Pharmacokinetics Cardiac transplant Pharmacogenetic analysis of the absorption kinetics of cyclosporine in a population of Spanish cardiac transplant patients B. Isla Tejera M.D. Aumente Rubio J. Martínez-Moreno M. Reyes Malia J.M. Arizón A. Suárez García Medicina Cyclosporine Pharmacogenetics Pharmacokinetics Cardiac transplant Objective: To determine how single nucleotide polymorphisms located on genes MDR1, CYP3A4, and CYP3A5 affect the absorption kinetics of cyclosporine in cardiac transplant patients. Method: We selected a sample of 30 adult patients having previously undergone a primary cardiac transplant and who had received cyclosporine as an immunosuppressant. During the Àrst month after the transplant, we performed a pharmacokinetic study of each patient to determine values in the cyclosporine concentration area under the 12-hour curve, steady-state cyclosporine concentration, maximum cyclosporine concentration, and time to reach that concentration. Single nucleotide polymorphisms were genotyped in all patients: MDR1 3435C > T, CYP3A4-390A > G, and CYP3A5 6986A > G. Results: Being a carrier of the T-allele for polymorphism MDR1 3435C > T is associated with higher values in the cyclosporine concentration area under the 12-hour curve (P=.01) and in steady-state cyclosporine concentration (P=.05), compared with those from patients who do not carry that allele. Discussion: Our results show that genotype differences in MDR1 3435C > T can explain part of the variability in cyclosporine absorption among individuals in the population of Spanish cardiac transplant recipients. 2009 artículo científico 1130-6343 https://www.redalyc.org/articulo.oa?id=365961793005 en http://www.redalyc.org/revista.oa?id=3659 Farmacia Hospitalaria application/pdf Sociedad Española de Farmacia Hospitalaria Farmacia Hospitalaria (España) Num.6 Vol.33 |
| title | Pharmacogenetic analysis of the absorption kinetics of cyclosporine in a population of Spanish cardiac transplant patients |
| topic | Medicina Cyclosporine Pharmacogenetics Pharmacokinetics Cardiac transplant |
| url | https://www.redalyc.org/articulo.oa?id=365961793005 |