Inhaled nitric oxide in adult patients with acute respiratory distress syndrome
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| Format: | Artículo científico |
| Language: | en |
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Sociedad Española de Farmacia Hospitalaria
2017
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| author | José Ángel Monsalve-Naharro |
| author_facet | José Ángel Monsalve-Naharro |
| contents | Inhaled nitric oxide in adult patients with acute respiratory distress syndrome José Ángel Monsalve-Naharro Esther Domingo-Chiva Sergio García Castillo Pablo Cuesta-Montero José María Jiménez-Vizuete Medicina Hypoxemia Nitric oxide Acute lung injury Acute respiratory distress syndrome In some patients, acute respiratory distress syndrome (ARDS) leads to life-threatening refractory hypoxemia developing. Physicians may consider hypoxemic rescue therapies in an attempt to improve oxygenation in these patients while on conventional mechanical ventilation support. Use of inhaled nitric oxide (iNO) in ARDS is one of the most widely-studied pharmacological interventions over the past two decades. Its efficacy was examined in several randomized clinical trials and has undergone meta-analyses. Although iNO treatment was associated with improved oxygenation, researchers unfortunately never demonstrated a concomitant decrease in mortality or any improved outcome. Hence the current evidence suggests that iNO should not be routinely used in patients with ARDS however may be considered as adjunct therapy to tentatively improve oxygenation while other therapies are being considered in patients with severely hypoxemic ARDS.This review focuses on the therapeutic use of iNO in adult ARDS patients. We set out some recommendations for its use as rescue therapy against refractory hypoxemia. 2017 artículo científico 1130-6343 https://www.redalyc.org/articulo.oa?id=365962268010 https://www.redalyc.org/journal/3659/365962268010/ https://www.redalyc.org/journal/3659/365962268010/html/ https://www.redalyc.org/journal/3659/365962268010/365962268010.epub https://www.redalyc.org/journal/3659/365962268010/movil 10.7399/fh.2017.41.2.10533 en http://www.redalyc.org/revista.oa?id=3659 Farmacia Hospitalaria application/pdf Sociedad Española de Farmacia Hospitalaria Farmacia Hospitalaria (España) Num.2 Vol.41 |
| format | Artículo científico |
| id | redalyc_365962268010 |
| institution | Redalyc |
| language | en |
| publishDate | 2017 |
| publisher | Sociedad Española de Farmacia Hospitalaria |
| spellingShingle | Inhaled nitric oxide in adult patients with acute respiratory distress syndrome José Ángel Monsalve-Naharro Medicina Hypoxemia Nitric oxide Acute lung injury Acute respiratory distress syndrome Inhaled nitric oxide in adult patients with acute respiratory distress syndrome José Ángel Monsalve-Naharro Esther Domingo-Chiva Sergio García Castillo Pablo Cuesta-Montero José María Jiménez-Vizuete Medicina Hypoxemia Nitric oxide Acute lung injury Acute respiratory distress syndrome In some patients, acute respiratory distress syndrome (ARDS) leads to life-threatening refractory hypoxemia developing. Physicians may consider hypoxemic rescue therapies in an attempt to improve oxygenation in these patients while on conventional mechanical ventilation support. Use of inhaled nitric oxide (iNO) in ARDS is one of the most widely-studied pharmacological interventions over the past two decades. Its efficacy was examined in several randomized clinical trials and has undergone meta-analyses. Although iNO treatment was associated with improved oxygenation, researchers unfortunately never demonstrated a concomitant decrease in mortality or any improved outcome. Hence the current evidence suggests that iNO should not be routinely used in patients with ARDS however may be considered as adjunct therapy to tentatively improve oxygenation while other therapies are being considered in patients with severely hypoxemic ARDS.This review focuses on the therapeutic use of iNO in adult ARDS patients. We set out some recommendations for its use as rescue therapy against refractory hypoxemia. 2017 artículo científico 1130-6343 https://www.redalyc.org/articulo.oa?id=365962268010 https://www.redalyc.org/journal/3659/365962268010/ https://www.redalyc.org/journal/3659/365962268010/html/ https://www.redalyc.org/journal/3659/365962268010/365962268010.epub https://www.redalyc.org/journal/3659/365962268010/movil 10.7399/fh.2017.41.2.10533 en http://www.redalyc.org/revista.oa?id=3659 Farmacia Hospitalaria application/pdf Sociedad Española de Farmacia Hospitalaria Farmacia Hospitalaria (España) Num.2 Vol.41 |
| title | Inhaled nitric oxide in adult patients with acute respiratory distress syndrome |
| topic | Medicina Hypoxemia Nitric oxide Acute lung injury Acute respiratory distress syndrome |
| url | https://www.redalyc.org/articulo.oa?id=365962268010 https://www.redalyc.org/journal/3659/365962268010/ https://www.redalyc.org/journal/3659/365962268010/html/ https://www.redalyc.org/journal/3659/365962268010/365962268010.epub https://www.redalyc.org/journal/3659/365962268010/movil |