Potential interactions in a cohort of elderly HIV-positive patients
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| Natura: | Artículo científico |
| Lingua: | en |
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Sociedad Española de Farmacia Hospitalaria
2018
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| _version_ | 1876476733884989440 |
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| author | Lorena Jiménez-Guerrero |
| author_facet | Lorena Jiménez-Guerrero |
| contents | Potential interactions in a cohort of elderly HIV-positive patients Lorena Jiménez-Guerrero María Núñez-Núñez Isabel Castañeda-Macías Santiago Sandoval-Fernández del Castillo Medicina HIV Aging Drug interactions Antiretroviral therapy Objective: An increased life expectancy leads to a new model of HIV patient with chronic diseases and occasionally polymedicated. With this study, we intend to understand treatment complexity and to identify any potential interactions between antiretroviral drugs and home medication in our patients, in order to identify and prevent them.Method: A retrospective, descriptive study carried out in a cohort of > 50-year-old patients on antiretroviral treatment in a tertiary hospital. Results: We included 242 patients; 148 (61%) of them were receiving some concomitant treatment. We detected 243 potential interactions: 197 considered moderate and 46 severe, in 110 patients.Of the severe interactions, 35 (76%) were related to boosted protease inhibitors.The main consequence of these interactions was an increase in the plasma concentrations of the home medication (48%).Statins (24%) were the group most involved in severe interactions, followed by inhaled corticosteroids (15%).Conclusions: Practically half of patients were polymedicated, and a high number of potential moderate or severe interactions were observed. The Hospital Pharmacist must play an essential role in their detection, management and early communication. 2018 artículo científico 1130-6343 https://www.redalyc.org/articulo.oa?id=365962269006 https://www.redalyc.org/journal/3659/365962269006/ https://www.redalyc.org/journal/3659/365962269006/html/ https://www.redalyc.org/journal/3659/365962269006/365962269006.epub https://www.redalyc.org/journal/3659/365962269006/movil 10.7399/fh.10921 en http://www.redalyc.org/revista.oa?id=3659 Farmacia Hospitalaria application/pdf Sociedad Española de Farmacia Hospitalaria Farmacia Hospitalaria (España) Num.4 Vol.42 |
| format | Artículo científico |
| id | redalyc_365962269006 |
| institution | Redalyc |
| language | en |
| publishDate | 2018 |
| publisher | Sociedad Española de Farmacia Hospitalaria |
| spellingShingle | Potential interactions in a cohort of elderly HIV-positive patients Lorena Jiménez-Guerrero Medicina HIV Aging Drug interactions Antiretroviral therapy Potential interactions in a cohort of elderly HIV-positive patients Lorena Jiménez-Guerrero María Núñez-Núñez Isabel Castañeda-Macías Santiago Sandoval-Fernández del Castillo Medicina HIV Aging Drug interactions Antiretroviral therapy Objective: An increased life expectancy leads to a new model of HIV patient with chronic diseases and occasionally polymedicated. With this study, we intend to understand treatment complexity and to identify any potential interactions between antiretroviral drugs and home medication in our patients, in order to identify and prevent them.Method: A retrospective, descriptive study carried out in a cohort of > 50-year-old patients on antiretroviral treatment in a tertiary hospital. Results: We included 242 patients; 148 (61%) of them were receiving some concomitant treatment. We detected 243 potential interactions: 197 considered moderate and 46 severe, in 110 patients.Of the severe interactions, 35 (76%) were related to boosted protease inhibitors.The main consequence of these interactions was an increase in the plasma concentrations of the home medication (48%).Statins (24%) were the group most involved in severe interactions, followed by inhaled corticosteroids (15%).Conclusions: Practically half of patients were polymedicated, and a high number of potential moderate or severe interactions were observed. The Hospital Pharmacist must play an essential role in their detection, management and early communication. 2018 artículo científico 1130-6343 https://www.redalyc.org/articulo.oa?id=365962269006 https://www.redalyc.org/journal/3659/365962269006/ https://www.redalyc.org/journal/3659/365962269006/html/ https://www.redalyc.org/journal/3659/365962269006/365962269006.epub https://www.redalyc.org/journal/3659/365962269006/movil 10.7399/fh.10921 en http://www.redalyc.org/revista.oa?id=3659 Farmacia Hospitalaria application/pdf Sociedad Española de Farmacia Hospitalaria Farmacia Hospitalaria (España) Num.4 Vol.42 |
| title | Potential interactions in a cohort of elderly HIV-positive patients |
| topic | Medicina HIV Aging Drug interactions Antiretroviral therapy |
| url | https://www.redalyc.org/articulo.oa?id=365962269006 https://www.redalyc.org/journal/3659/365962269006/ https://www.redalyc.org/journal/3659/365962269006/html/ https://www.redalyc.org/journal/3659/365962269006/365962269006.epub https://www.redalyc.org/journal/3659/365962269006/movil |