Long-term stability of trastuzumab in plasma and whole blood samples stored under different conditions
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Sociedad Española de Farmacia Hospitalaria
2019
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| _version_ | 1876465936725180416 |
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| author | Jonathan González-García |
| author_facet | Jonathan González-García |
| contents | Long-term stability of trastuzumab in plasma and whole blood samples stored under different conditions Jonathan González-García Fernando Gutiérrez-Nicolás Gloria Julia Nazco-Casariego María Micaela Viña-Romero Medicina Storage Stability Blood serum Trastuzumab Blood plasma Objective: The present work analyzed the stability of trastuzumab concentrations in blood and plasma samples stored at 4 °C and -20 °C. Method: Blood samples of patients treated with trastuzumab (Herceptin®) were analyzed. Stability of trastuzumab was analyzed under different conditions: whole blood stored at 4 °C during 72 hours, blood plasma stored at 4 °C during 120 hours and blood plasma stored at -20 °C during 365 days.Results: In whole blood trastuzumab concentration at 72 hours was 99.01 ± 0.02%, and in plasma samples at 120 hours it was 98.6 ± 2.0%. The concentration of trastuzumab was 95.22 ± 3.20% after 12 months’ storage at -20 ºC.Conclusions: The concentration of trastuzumab remains stable for at least 72 hours in whole blood stored at 4 °C, five days in plasma stored at 4 °C and one year in plasma stored at -20 °C. 2019 artículo científico 1130-6343 https://www.redalyc.org/articulo.oa?id=365962275003 https://www.redalyc.org/journal/3659/365962275003/ https://www.redalyc.org/journal/3659/365962275003/html/ https://www.redalyc.org/journal/3659/365962275003/365962275003.epub https://www.redalyc.org/journal/3659/365962275003/movil 10.7399/fh.11110 en http://www.redalyc.org/revista.oa?id=3659 Farmacia Hospitalaria application/pdf Sociedad Española de Farmacia Hospitalaria Farmacia Hospitalaria (España) Num.2 Vol.43 |
| format | Artículo científico |
| id | redalyc_365962275003 |
| institution | Redalyc |
| language | en |
| publishDate | 2019 |
| publisher | Sociedad Española de Farmacia Hospitalaria |
| spellingShingle | Long-term stability of trastuzumab in plasma and whole blood samples stored under different conditions Jonathan González-García Medicina Storage Stability Blood serum Trastuzumab Blood plasma Long-term stability of trastuzumab in plasma and whole blood samples stored under different conditions Jonathan González-García Fernando Gutiérrez-Nicolás Gloria Julia Nazco-Casariego María Micaela Viña-Romero Medicina Storage Stability Blood serum Trastuzumab Blood plasma Objective: The present work analyzed the stability of trastuzumab concentrations in blood and plasma samples stored at 4 °C and -20 °C. Method: Blood samples of patients treated with trastuzumab (Herceptin®) were analyzed. Stability of trastuzumab was analyzed under different conditions: whole blood stored at 4 °C during 72 hours, blood plasma stored at 4 °C during 120 hours and blood plasma stored at -20 °C during 365 days.Results: In whole blood trastuzumab concentration at 72 hours was 99.01 ± 0.02%, and in plasma samples at 120 hours it was 98.6 ± 2.0%. The concentration of trastuzumab was 95.22 ± 3.20% after 12 months’ storage at -20 ºC.Conclusions: The concentration of trastuzumab remains stable for at least 72 hours in whole blood stored at 4 °C, five days in plasma stored at 4 °C and one year in plasma stored at -20 °C. 2019 artículo científico 1130-6343 https://www.redalyc.org/articulo.oa?id=365962275003 https://www.redalyc.org/journal/3659/365962275003/ https://www.redalyc.org/journal/3659/365962275003/html/ https://www.redalyc.org/journal/3659/365962275003/365962275003.epub https://www.redalyc.org/journal/3659/365962275003/movil 10.7399/fh.11110 en http://www.redalyc.org/revista.oa?id=3659 Farmacia Hospitalaria application/pdf Sociedad Española de Farmacia Hospitalaria Farmacia Hospitalaria (España) Num.2 Vol.43 |
| title | Long-term stability of trastuzumab in plasma and whole blood samples stored under different conditions |
| topic | Medicina Storage Stability Blood serum Trastuzumab Blood plasma |
| url | https://www.redalyc.org/articulo.oa?id=365962275003 https://www.redalyc.org/journal/3659/365962275003/ https://www.redalyc.org/journal/3659/365962275003/html/ https://www.redalyc.org/journal/3659/365962275003/365962275003.epub https://www.redalyc.org/journal/3659/365962275003/movil |