Analysis of acenocoumarol and levofloxacin interaction in elderly institutionalized patients
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Sociedad Española de Farmacia Hospitalaria
2019
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| _version_ | 1876480857857851392 |
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| author | Pilar Taberner-Bonastre |
| author_facet | Pilar Taberner-Bonastre |
| contents | Analysis of acenocoumarol and levofloxacin interaction in elderly institutionalized patients Pilar Taberner-Bonastre Ana Moreno-Miralles Isabel Quintana-Vargas Juan Francisco Peris-Martí Medicina Elderly Interaction Levofloxacin Nursing home Acenocoumarol Objective: To analyze the interaction between acenocoumarol and levofloxacin in the elderly. We also assessed how hypoalbuminemia affects international normalized ratio variation.Method: Retrospective study carried on elderly institutionalized patients who were prescribed levofloxacin concomitantly with acenocoumarol. International normalized ratio variation during levofloxacin treatment was analyzed with the t-Student test. Correlation between albuminemia and international normalized ratio variation was calculated using Pearson´s correlation coefficient.Results: The mean international normalized ratio previous to treatment with levofloxacin was 2.5 (standard deviation: 0.6) and during treatment it was 4.7 (standard deviation: 1.9) (p < 0.05). In 54.3% of the cases, the international normalized ratio value was equal to or greater than 4.5. Not linear association between albuminemia and international normalized ratio increase was found using Pearson´s test (R = -0.16).Conclusions: In more than half of the occasions international normalized ratio raised to clinically rellevant values (≥ 4.5). No influence of hypoalbuminemia in the increase in international normalized ratio was shown. 2019 artículo científico 1130-6343 https://www.redalyc.org/articulo.oa?id=365962275006 https://www.redalyc.org/journal/3659/365962275006/ https://www.redalyc.org/journal/3659/365962275006/html/ https://www.redalyc.org/journal/3659/365962275006/365962275006.epub https://www.redalyc.org/journal/3659/365962275006/movil 10.7399/fh.11111 en http://www.redalyc.org/revista.oa?id=3659 Farmacia Hospitalaria application/pdf Sociedad Española de Farmacia Hospitalaria Farmacia Hospitalaria (España) Num.2 Vol.43 |
| format | Artículo científico |
| id | redalyc_365962275006 |
| institution | Redalyc |
| language | en |
| publishDate | 2019 |
| publisher | Sociedad Española de Farmacia Hospitalaria |
| spellingShingle | Analysis of acenocoumarol and levofloxacin interaction in elderly institutionalized patients Pilar Taberner-Bonastre Medicina Elderly Interaction Levofloxacin Nursing home Acenocoumarol Analysis of acenocoumarol and levofloxacin interaction in elderly institutionalized patients Pilar Taberner-Bonastre Ana Moreno-Miralles Isabel Quintana-Vargas Juan Francisco Peris-Martí Medicina Elderly Interaction Levofloxacin Nursing home Acenocoumarol Objective: To analyze the interaction between acenocoumarol and levofloxacin in the elderly. We also assessed how hypoalbuminemia affects international normalized ratio variation.Method: Retrospective study carried on elderly institutionalized patients who were prescribed levofloxacin concomitantly with acenocoumarol. International normalized ratio variation during levofloxacin treatment was analyzed with the t-Student test. Correlation between albuminemia and international normalized ratio variation was calculated using Pearson´s correlation coefficient.Results: The mean international normalized ratio previous to treatment with levofloxacin was 2.5 (standard deviation: 0.6) and during treatment it was 4.7 (standard deviation: 1.9) (p < 0.05). In 54.3% of the cases, the international normalized ratio value was equal to or greater than 4.5. Not linear association between albuminemia and international normalized ratio increase was found using Pearson´s test (R = -0.16).Conclusions: In more than half of the occasions international normalized ratio raised to clinically rellevant values (≥ 4.5). No influence of hypoalbuminemia in the increase in international normalized ratio was shown. 2019 artículo científico 1130-6343 https://www.redalyc.org/articulo.oa?id=365962275006 https://www.redalyc.org/journal/3659/365962275006/ https://www.redalyc.org/journal/3659/365962275006/html/ https://www.redalyc.org/journal/3659/365962275006/365962275006.epub https://www.redalyc.org/journal/3659/365962275006/movil 10.7399/fh.11111 en http://www.redalyc.org/revista.oa?id=3659 Farmacia Hospitalaria application/pdf Sociedad Española de Farmacia Hospitalaria Farmacia Hospitalaria (España) Num.2 Vol.43 |
| title | Analysis of acenocoumarol and levofloxacin interaction in elderly institutionalized patients |
| topic | Medicina Elderly Interaction Levofloxacin Nursing home Acenocoumarol |
| url | https://www.redalyc.org/articulo.oa?id=365962275006 https://www.redalyc.org/journal/3659/365962275006/ https://www.redalyc.org/journal/3659/365962275006/html/ https://www.redalyc.org/journal/3659/365962275006/365962275006.epub https://www.redalyc.org/journal/3659/365962275006/movil |