Evaluation of standardized triple intrathecal therapy toxicity in oncohematological adult patients
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Sociedad Española de Farmacia Hospitalaria
2017
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| _version_ | 1876469384923316224 |
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| author | Raquel Olmos-Jiménez |
| author_facet | Raquel Olmos-Jiménez |
| contents | Evaluation of standardized triple intrathecal therapy toxicity in oncohematological adult patients Raquel Olmos-Jiménez María Sacramento Díaz-Carrasco Valentín Cabañas-Perianes Manuel Valderrey Pulido Alberto Espuny-Miró Medicina Risk factors Drug toxicity Standardization Hematological neoplasms Intrathecal chemotherapy Objective: To assess the toxicity of a standardized triple intrathecal chemotherapy in onco-hematological adult patients and to establish risk factors of toxicity.Method: Observational and prospective study of standardized triple intrathecal chemotherapy administrations in onco-hematologic adult patients for 18 months.Results: There were some adverse events in 39.3% of the 56 administrations registered. 96.7% of the events were grade 1-2 and only 1 event was grade 3. The lower age of the patient and the greater difference between the administered drug volume and cerebrospinal fluid removed volume were shown as risk factors for toxicity.Conclusions: The administration of standardized triple intrathecal chemotherapy was related to a low frequency of toxicity and most of adverse events were mild-moderate. The detection of adverse effects was significantly greater in young adults and in those administrations where the difference between cerebrospinal fluid remove volume and the administered drug was greater. 2017 artículo científico 1130-6343 https://www.redalyc.org/articulo.oa?id=365962297006 https://www.redalyc.org/journal/3659/365962297006/ https://www.redalyc.org/journal/3659/365962297006/html/ https://www.redalyc.org/journal/3659/365962297006/365962297006.epub https://www.redalyc.org/journal/3659/365962297006/movil 10.7399/fh.10762 en http://www.redalyc.org/revista.oa?id=3659 Farmacia Hospitalaria application/pdf Sociedad Española de Farmacia Hospitalaria Farmacia Hospitalaria (España) Num.5 Vol.41 |
| format | Artículo científico |
| id | redalyc_365962297006 |
| institution | Redalyc |
| language | en |
| publishDate | 2017 |
| publisher | Sociedad Española de Farmacia Hospitalaria |
| spellingShingle | Evaluation of standardized triple intrathecal therapy toxicity in oncohematological adult patients Raquel Olmos-Jiménez Medicina Risk factors Drug toxicity Standardization Hematological neoplasms Intrathecal chemotherapy Evaluation of standardized triple intrathecal therapy toxicity in oncohematological adult patients Raquel Olmos-Jiménez María Sacramento Díaz-Carrasco Valentín Cabañas-Perianes Manuel Valderrey Pulido Alberto Espuny-Miró Medicina Risk factors Drug toxicity Standardization Hematological neoplasms Intrathecal chemotherapy Objective: To assess the toxicity of a standardized triple intrathecal chemotherapy in onco-hematological adult patients and to establish risk factors of toxicity.Method: Observational and prospective study of standardized triple intrathecal chemotherapy administrations in onco-hematologic adult patients for 18 months.Results: There were some adverse events in 39.3% of the 56 administrations registered. 96.7% of the events were grade 1-2 and only 1 event was grade 3. The lower age of the patient and the greater difference between the administered drug volume and cerebrospinal fluid removed volume were shown as risk factors for toxicity.Conclusions: The administration of standardized triple intrathecal chemotherapy was related to a low frequency of toxicity and most of adverse events were mild-moderate. The detection of adverse effects was significantly greater in young adults and in those administrations where the difference between cerebrospinal fluid remove volume and the administered drug was greater. 2017 artículo científico 1130-6343 https://www.redalyc.org/articulo.oa?id=365962297006 https://www.redalyc.org/journal/3659/365962297006/ https://www.redalyc.org/journal/3659/365962297006/html/ https://www.redalyc.org/journal/3659/365962297006/365962297006.epub https://www.redalyc.org/journal/3659/365962297006/movil 10.7399/fh.10762 en http://www.redalyc.org/revista.oa?id=3659 Farmacia Hospitalaria application/pdf Sociedad Española de Farmacia Hospitalaria Farmacia Hospitalaria (España) Num.5 Vol.41 |
| title | Evaluation of standardized triple intrathecal therapy toxicity in oncohematological adult patients |
| topic | Medicina Risk factors Drug toxicity Standardization Hematological neoplasms Intrathecal chemotherapy |
| url | https://www.redalyc.org/articulo.oa?id=365962297006 https://www.redalyc.org/journal/3659/365962297006/ https://www.redalyc.org/journal/3659/365962297006/html/ https://www.redalyc.org/journal/3659/365962297006/365962297006.epub https://www.redalyc.org/journal/3659/365962297006/movil |