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| Autore principale: | |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Sociedad Española de Farmacia Hospitalaria
2012
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| Soggetti: | |
| Accesso online: | https://www.redalyc.org/articulo.oa?id=365962448005 |
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Sommario:
- Coenzyme Q10 stability in pediatric liquid oral dosage formulations P. N. Estévez V. Tripodi F. Buontempo S. Lucangioli Medicina HPLC Pediatric Stability Formulation Coenzyme Q10 Objective: To study the stability of Coenzyme Q10 (CoQ10), used as therapeutic agent in treatment of cardiovascular andmitochondrial diseases, in three liquid formulations: twosoybean oil solutions (50 mg/ml), one of them with theaddition of vitamin E and an O/W emulsion (20 mg/ml) forpediatric use. Furthermore, optimize and validate a stability-indicating HPLC method for the analysis of CoQ10 in thestudied formulations. Method: All samples were stored at 25°C. CoQ10 content ofeach formulation was analyzed in duplicate using fastmicrobore high performance liquid chromatography (MicroHPLC) at 0, 3, 6, 15, 30, 60 and 110 days. Results: All formulations stayed stable at 25°C during the 110 days of the study. However, the oil solutions presented greatercontent variations through all the study period. Conclusions: The CoQ10 emulsion can be stored for at least110 days at 25 °C and it has proven to be safer when narrowdose adjustment is required. The proposed analytical methodwas suitable for the study of stability of different formulationsmeeting the validation parameters according to international guidelines. 2012 artículo científico 1130-6343 https://www.redalyc.org/articulo.oa?id=365962448005 en http://www.redalyc.org/revista.oa?id=3659 Farmacia Hospitalaria application/pdf Sociedad Española de Farmacia Hospitalaria Farmacia Hospitalaria (España) Num.6 Vol.36