Cytogenetic effects of inhalation of a mosquito repellent vapour on target and nontarget cells of rats
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| Format: | Artículo científico |
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Universidad Nacional Autónoma de México
1996
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| _version_ | 1876453651832111104 |
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| author | Kalakar Sahu |
| author_facet | Kalakar Sahu |
| contents | Cytogenetic effects of inhalation of a mosquito repellent vapour on target and nontarget cells of rats Kalakar Sahu Ranjit K. Das Ciencias de la Tierra "M Out" micronucleus genotoxic effect mosquito repellent chromosome aberrations Genotoxic potential of inhalation of "All Outw (AO), a liquid mosquito repellent, vapour (AOV) wasevaluated in target (pulmonary alveolar macrophages or PAMs) and non-target (bone marrow or BM)ce11s of rats. Evaluation was based on analysis of chromosome aberrations (CAs) in PAMs and BM cells,and micronuclei (MN) in PAMs. The rats were exposed to static vapour intermiíiently in a closedinhalation chamber (15 miníh, 8 híday) for short-term (1 day) exposure and (15 minlh, 8 híday, 7 daylweek) for long-term (7 days) exposure. Animals were killed 24 h and 32 h afer the final exposure forCA and MN studies respectively. Concentration-response analysis done by exposing the animals inAOV collected for different periods (1, 5 and 10 min) for both CAs and MN showed a good positivecorrelation; significantly higher frequencies, compared to the respective controls, of CAs and MN wereobtained for the highest concentration tested. In no case the incidence of CAs in BM cells differedsignificantly from the control value. Insecticide present in A0 is supposed to be responsible for causingchromosome damage. Differential response of PAMs and BM cells has been discussed from the point oftarget and non-Wrget cells. Lack of any remarkable difference in effect for 1 and 7 day exposures seemsto be due to the proliferative nature of the cells. 1996 artículo científico 0188-4999 https://www.redalyc.org/articulo.oa?id=37012105 en http://www.redalyc.org/revista.oa?id=370 Revista Internacional de Contaminación Ambiental application/pdf Universidad Nacional Autónoma de México Revista Internacional de Contaminación Ambiental (México) Num.1 Vol.12 |
| format | Artículo científico |
| id | redalyc_37012105 |
| institution | Redalyc |
| language | en |
| publishDate | 1996 |
| publisher | Universidad Nacional Autónoma de México |
| spellingShingle | Cytogenetic effects of inhalation of a mosquito repellent vapour on target and nontarget cells of rats Kalakar Sahu Ciencias de la Tierra "M Out" micronucleus genotoxic effect mosquito repellent chromosome aberrations Cytogenetic effects of inhalation of a mosquito repellent vapour on target and nontarget cells of rats Kalakar Sahu Ranjit K. Das Ciencias de la Tierra "M Out" micronucleus genotoxic effect mosquito repellent chromosome aberrations Genotoxic potential of inhalation of "All Outw (AO), a liquid mosquito repellent, vapour (AOV) wasevaluated in target (pulmonary alveolar macrophages or PAMs) and non-target (bone marrow or BM)ce11s of rats. Evaluation was based on analysis of chromosome aberrations (CAs) in PAMs and BM cells,and micronuclei (MN) in PAMs. The rats were exposed to static vapour intermiíiently in a closedinhalation chamber (15 miníh, 8 híday) for short-term (1 day) exposure and (15 minlh, 8 híday, 7 daylweek) for long-term (7 days) exposure. Animals were killed 24 h and 32 h afer the final exposure forCA and MN studies respectively. Concentration-response analysis done by exposing the animals inAOV collected for different periods (1, 5 and 10 min) for both CAs and MN showed a good positivecorrelation; significantly higher frequencies, compared to the respective controls, of CAs and MN wereobtained for the highest concentration tested. In no case the incidence of CAs in BM cells differedsignificantly from the control value. Insecticide present in A0 is supposed to be responsible for causingchromosome damage. Differential response of PAMs and BM cells has been discussed from the point oftarget and non-Wrget cells. Lack of any remarkable difference in effect for 1 and 7 day exposures seemsto be due to the proliferative nature of the cells. 1996 artículo científico 0188-4999 https://www.redalyc.org/articulo.oa?id=37012105 en http://www.redalyc.org/revista.oa?id=370 Revista Internacional de Contaminación Ambiental application/pdf Universidad Nacional Autónoma de México Revista Internacional de Contaminación Ambiental (México) Num.1 Vol.12 |
| title | Cytogenetic effects of inhalation of a mosquito repellent vapour on target and nontarget cells of rats |
| topic | Ciencias de la Tierra "M Out" micronucleus genotoxic effect mosquito repellent chromosome aberrations |
| url | https://www.redalyc.org/articulo.oa?id=37012105 |