Genotoxicity testing of promutagens in the wing somatic mutation and recombination test in Drosophila melanogaster
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| Format: | Artículo científico |
| Sprache: | en |
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Universidad Nacional Autónoma de México
1992
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| _version_ | 1876430632362442752 |
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| author | Doris Singer |
| author_facet | Doris Singer |
| contents | Genotoxicity testing of promutagens in the wing somatic mutation and recombination test in Drosophila melanogaster Doris Singer Ulrich Graf Ciencias de la Tierra Drosophila genotoxicity somatic cells naphthylamine phenobarbital The wing Somatic Mutation and Recombination Test (SMART) in Drosophila melanogusterhas been used to analyse five different promutagens for genotoxicity using the standardcross and the high bioactivation cross. Benz(a)anthracene and N-nitrosodiphenylaminewere weakly positive in the standard cross both after 48 h and 72 h chronic feeding. However,the dose-response relationship showed a plateau. Of the two naphthylamines, the carcinogen2-naphthylamine was also weakly positive in the standard cross at the highest concentrationtesced. The carcinogen N-nitrosopyrrolidine was tested in the standard cross usingboth 48 h and 72 h chronic feeding as well as 6 h acute feeding. It proved to be highlymutagenic and recombinagenic with a clear-cut dose-response. The genotoxicity of thispromutagen can be enhanced by a factor of two to four when the high bioactivation cross isused or when the larvae are pretreated for 24 h with phenobarbital. These results demonstratethe sensitivity and versatility of the Drosophila wing spot test for the evaluation ofgenotoxic activity of promutagens and procarcinogens. 1992 artículo científico 0188-4999 https://www.redalyc.org/articulo.oa?id=37080101 en http://www.redalyc.org/revista.oa?id=370 Revista Internacional de Contaminación Ambiental application/pdf Universidad Nacional Autónoma de México Revista Internacional de Contaminación Ambiental (México) Num.1 Vol.8 |
| format | Artículo científico |
| id | redalyc_37080101 |
| institution | Redalyc |
| language | en |
| publishDate | 1992 |
| publisher | Universidad Nacional Autónoma de México |
| spellingShingle | Genotoxicity testing of promutagens in the wing somatic mutation and recombination test in Drosophila melanogaster Doris Singer Ciencias de la Tierra Drosophila genotoxicity somatic cells naphthylamine phenobarbital Genotoxicity testing of promutagens in the wing somatic mutation and recombination test in Drosophila melanogaster Doris Singer Ulrich Graf Ciencias de la Tierra Drosophila genotoxicity somatic cells naphthylamine phenobarbital The wing Somatic Mutation and Recombination Test (SMART) in Drosophila melanogusterhas been used to analyse five different promutagens for genotoxicity using the standardcross and the high bioactivation cross. Benz(a)anthracene and N-nitrosodiphenylaminewere weakly positive in the standard cross both after 48 h and 72 h chronic feeding. However,the dose-response relationship showed a plateau. Of the two naphthylamines, the carcinogen2-naphthylamine was also weakly positive in the standard cross at the highest concentrationtesced. The carcinogen N-nitrosopyrrolidine was tested in the standard cross usingboth 48 h and 72 h chronic feeding as well as 6 h acute feeding. It proved to be highlymutagenic and recombinagenic with a clear-cut dose-response. The genotoxicity of thispromutagen can be enhanced by a factor of two to four when the high bioactivation cross isused or when the larvae are pretreated for 24 h with phenobarbital. These results demonstratethe sensitivity and versatility of the Drosophila wing spot test for the evaluation ofgenotoxic activity of promutagens and procarcinogens. 1992 artículo científico 0188-4999 https://www.redalyc.org/articulo.oa?id=37080101 en http://www.redalyc.org/revista.oa?id=370 Revista Internacional de Contaminación Ambiental application/pdf Universidad Nacional Autónoma de México Revista Internacional de Contaminación Ambiental (México) Num.1 Vol.8 |
| title | Genotoxicity testing of promutagens in the wing somatic mutation and recombination test in Drosophila melanogaster |
| topic | Ciencias de la Tierra Drosophila genotoxicity somatic cells naphthylamine phenobarbital |
| url | https://www.redalyc.org/articulo.oa?id=37080101 |