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Main Author:	Loida Ponce
Format:	Artículo científico
Language:	es
Published:	Universidad de Carabobo 2016
Subjects:	Medicina montelukast mediadores inflamatorios Modelo experimental de artritis gotosa
Online Access:	https://www.redalyc.org/articulo.oa?id=375949531004
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Efecto del montelukast sobre la concentración de mediadores inflamatorios en el modelo de artritis gotosa múrida. Loida Ponce Mariangélica Bermúdez Jorgelin Miranda Julie Verzura Robert Tovar José Corado Medicina montelukast mediadores inflamatorios Modelo experimental de artritis gotosa El tratamiento de la artritis gotosa controla parcialmente la enfermedad con efectos secundarios importantes. El montelukast es un antagonista selectivo de los receptores de leucotrienos LTD4, ˙til en el tratamiento de rinitis alÈrgica y asma bronquial. Investigaciones previas han reportado un potente efecto antiinflamatorio de montelukast en el modelo de artritis gotosa m˙rida. Este estudio investigÛ el efecto de montelukast sobre la concentraciÛn de leucotrienos cisteinil y LTB4, interleucina 6 (IL-6) e interleucina 12 (IL-12) en el exudado inflamatorio inducido por monourato sÛdico (MUS) en el modelo de la bolsa de aire. Veinti˙n ratones BALB/c fueron distribuidos en tres grupos (n: 7), control negativo de inflamación (A), control positivo de inflamación (B) y experimental (C). Antes de la inyecciÛn de MUS (5 mg/mL), en la bolsa de aire, los grupos C y B recibieron por vÌa oral 1mg/kg de montelukast y solución fisiológica respectivamente, el grupo A fue tratado con solución fisiológica por vía oral y en la bolsa de aire. A las 12 horas de haber inducido el proceso inflamatorio se determinó, por ELISA, la concentraciÛn de CistLT, LTB4, IL-6 e IL-12 en el exudado obtenido de las bolsas de aire. Los resultados muestran que el montelukast disminuye significativamente (p < 0,05) las concentraciones de LTB4, IL-6 e IL-12 en el exudado inflamatorio inducido por MUS, y aumenta significativamente (p < 0,05) las concentraciones de CistLT. Esto sugiere que la dosis empleada de montelukast posee un poderoso efecto antiinflamatorio con potencial beneficio en el tratamiento de la artritis gotosa. 2016 artículo científico 1316-7138 https://www.redalyc.org/articulo.oa?id=375949531004 es http://www.redalyc.org/revista.oa?id=3759 Salus application/pdf Universidad de Carabobo Salus (República Bolivariana de Venezuela) Num.3 Vol.20

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