Riesgo de enfermedad tuberculosa en pacientes con artritis reumatoide
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| Natura: | Artículo científico |
| Lingua: | en |
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Universidad Nacional Mayor de San Marcos
2006
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| _version_ | 1876438440222916608 |
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| author | Rocío Gamboa Cárdenas |
| author_facet | Rocío Gamboa Cárdenas |
| contents | Riesgo de enfermedad tuberculosa en pacientes con artritis reumatoide Rocío Gamboa Cárdenas Eduardo Acevedo Darío Ponce de León César Pastor José Alfaro Mariano Cucho Risto Perich César Gutiérrez Alfredo Sánchez Medicina Arthritis rheumatoid tuberculosis risk factors cohort studies Background: Studies on tuberculosis (TB) risk in patients withrheumatoid arthritis (RA) non-users of biological therapy showcontradictory results. Objetives: To determine RA as independentrisk factor for TB. Design: Non concurrent cohort study. Setting:Guillermo Almenara Asistential Net, Lima-Peru, a teachinghospital. Participants: Biological therapy non users RA patients.Interventions: RA patients fulfilled the ARA 1987 diagnosis criteria and were biological therapy non-users. Control group was pairedby age and sex to RA patients. Patients in control groups had nonimmunological disorders. Clinical information was completed byinterviews. RA patients follow-up was started at the time ofdiagnosis and ended at the time of interview and/or TB diagnosis.Density incidence (DI) was found for each cohort and TB relativerisk (RR) was calculated. To evaluate time length to TB evolutiona Kaplan Meier curve was graphed and compared both groupswith log-rank test. Drugs and predisposing TB pathologies wereanalyzed. Main outcome measures: Tuberculosis in patients withrheumatoid arthritis. Results: Six hundred and seventy six out of808 RA patients and 664 controls qualified for inclusion criterias.RA and control groups reached 6 940,75 and 6 666,53 follow-uppatients-year, respectively. RA cohort mean age was 46,65 at RAdiagnosis. Only 29,7% of RA patients had a positive tuberculinreaction. Fifteen TB cases were identified in the RA cohort and 8 atthe control group, yielding a mean DI of 216,1/100 000 and 122,1/ 100 000 patients-year respectively. TB RR was 1,8 (IC 95%=0,8-4,2), and after adjusting drugs and co-morbidity the HR was 1,69(IC 95%=0,26-10,93). Statistically significant difference was notfound with Kaplan Meier curves comparison (p=0,19).Conclusions: We did not find a higher risk of rheumatoid arthritispatients to develop tuberculosis. 2006 artículo científico 1025-5583 https://www.redalyc.org/articulo.oa?id=37967405 en http://www.redalyc.org/revista.oa?id=379 Anales de la Facultad de Medicina application/pdf Universidad Nacional Mayor de San Marcos Anales de la Facultad de Medicina (Perú) Num.4 Vol.67 |
| format | Artículo científico |
| id | redalyc_37967405 |
| institution | Redalyc |
| language | en |
| publishDate | 2006 |
| publisher | Universidad Nacional Mayor de San Marcos |
| spellingShingle | Riesgo de enfermedad tuberculosa en pacientes con artritis reumatoide Rocío Gamboa Cárdenas Medicina Arthritis rheumatoid tuberculosis risk factors cohort studies Riesgo de enfermedad tuberculosa en pacientes con artritis reumatoide Rocío Gamboa Cárdenas Eduardo Acevedo Darío Ponce de León César Pastor José Alfaro Mariano Cucho Risto Perich César Gutiérrez Alfredo Sánchez Medicina Arthritis rheumatoid tuberculosis risk factors cohort studies Background: Studies on tuberculosis (TB) risk in patients withrheumatoid arthritis (RA) non-users of biological therapy showcontradictory results. Objetives: To determine RA as independentrisk factor for TB. Design: Non concurrent cohort study. Setting:Guillermo Almenara Asistential Net, Lima-Peru, a teachinghospital. Participants: Biological therapy non users RA patients.Interventions: RA patients fulfilled the ARA 1987 diagnosis criteria and were biological therapy non-users. Control group was pairedby age and sex to RA patients. Patients in control groups had nonimmunological disorders. Clinical information was completed byinterviews. RA patients follow-up was started at the time ofdiagnosis and ended at the time of interview and/or TB diagnosis.Density incidence (DI) was found for each cohort and TB relativerisk (RR) was calculated. To evaluate time length to TB evolutiona Kaplan Meier curve was graphed and compared both groupswith log-rank test. Drugs and predisposing TB pathologies wereanalyzed. Main outcome measures: Tuberculosis in patients withrheumatoid arthritis. Results: Six hundred and seventy six out of808 RA patients and 664 controls qualified for inclusion criterias.RA and control groups reached 6 940,75 and 6 666,53 follow-uppatients-year, respectively. RA cohort mean age was 46,65 at RAdiagnosis. Only 29,7% of RA patients had a positive tuberculinreaction. Fifteen TB cases were identified in the RA cohort and 8 atthe control group, yielding a mean DI of 216,1/100 000 and 122,1/ 100 000 patients-year respectively. TB RR was 1,8 (IC 95%=0,8-4,2), and after adjusting drugs and co-morbidity the HR was 1,69(IC 95%=0,26-10,93). Statistically significant difference was notfound with Kaplan Meier curves comparison (p=0,19).Conclusions: We did not find a higher risk of rheumatoid arthritispatients to develop tuberculosis. 2006 artículo científico 1025-5583 https://www.redalyc.org/articulo.oa?id=37967405 en http://www.redalyc.org/revista.oa?id=379 Anales de la Facultad de Medicina application/pdf Universidad Nacional Mayor de San Marcos Anales de la Facultad de Medicina (Perú) Num.4 Vol.67 |
| title | Riesgo de enfermedad tuberculosa en pacientes con artritis reumatoide |
| topic | Medicina Arthritis rheumatoid tuberculosis risk factors cohort studies |
| url | https://www.redalyc.org/articulo.oa?id=37967405 |