Artemisia annua increases resistance to heat and oxidative stresses, but has no effect on lifespan in Caenorhabditis elegans
Fuente:
Redalyc
Salvato in:
| Autore principale: | |
|---|---|
| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos
2016
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1876434597244305408 |
|---|---|
| author | Seung-Il OH |
| author_facet | Seung-Il OH |
| contents | Artemisia annua increases resistance to heat and oxidative stresses, but has no effect on lifespan in Caenorhabditis elegans Seung-Il OH Jun-Sung KIM Chul-Kyu KIM Sun Shin YI Sung-Jo KIM Sang-Kyu PARK Agrociencias elegans lifespan heat stress Artemisia annua oxidative stress It is suggested that oxidative stress induced by cellular reactive oxygen species is one of the major causal factors of aging. The effect of dietary supplementation of anti-oxidants on response to environmental stressors and lifespan has been studied in various model organisms. In the present study, we examine the effect of Artemisia annua extract on resistance to oxidative, heat, and ultraviolet stresses in the nematode Caenorhabditis elegans. Artemisia annua significantly increases survival under oxidative and heat stresses, however has no effects in response to ultraviolet stress. Then, we measured the in vivo changes in expression of stress-responsive genes by Artemisia annua using green fluorescence protein. The expression of hsp-16.2, known to be involved in response to heat stress, is significantly increased by Artemisia annua supplementation. An anti-oxidant gene, sod-3, was also up-regulated by Artemisia annua. However, both mean and maximum lifespan of Caenorhabditis elegans was not altered by dietary supplementation of Artemisia annua. These findings indicate that Artemisia annua confers health-promoting effects through increasing the resistance to environmental stressors and has no effect on lifespan in C. elegans. Dur study suggests that Artemisia annua can be used for the development of novel natural therapeutics for diseases caused by environmental stressors. 2016 artículo científico 0101-2061 https://www.redalyc.org/articulo.oa?id=395946786021 en http://www.redalyc.org/revista.oa?id=3959 Ciência e Tecnologia de Alimentos application/pdf Sociedade Brasileira de Ciência e Tecnologia de Alimentos Ciência e Tecnologia de Alimentos (Brasil) Num.2 Vol.36 |
| format | Artículo científico |
| id | redalyc_395946786021 |
| institution | Redalyc |
| language | en |
| publishDate | 2016 |
| publisher | Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
| spellingShingle | Artemisia annua increases resistance to heat and oxidative stresses, but has no effect on lifespan in Caenorhabditis elegans Seung-Il OH Agrociencias elegans lifespan heat stress Artemisia annua oxidative stress Artemisia annua increases resistance to heat and oxidative stresses, but has no effect on lifespan in Caenorhabditis elegans Seung-Il OH Jun-Sung KIM Chul-Kyu KIM Sun Shin YI Sung-Jo KIM Sang-Kyu PARK Agrociencias elegans lifespan heat stress Artemisia annua oxidative stress It is suggested that oxidative stress induced by cellular reactive oxygen species is one of the major causal factors of aging. The effect of dietary supplementation of anti-oxidants on response to environmental stressors and lifespan has been studied in various model organisms. In the present study, we examine the effect of Artemisia annua extract on resistance to oxidative, heat, and ultraviolet stresses in the nematode Caenorhabditis elegans. Artemisia annua significantly increases survival under oxidative and heat stresses, however has no effects in response to ultraviolet stress. Then, we measured the in vivo changes in expression of stress-responsive genes by Artemisia annua using green fluorescence protein. The expression of hsp-16.2, known to be involved in response to heat stress, is significantly increased by Artemisia annua supplementation. An anti-oxidant gene, sod-3, was also up-regulated by Artemisia annua. However, both mean and maximum lifespan of Caenorhabditis elegans was not altered by dietary supplementation of Artemisia annua. These findings indicate that Artemisia annua confers health-promoting effects through increasing the resistance to environmental stressors and has no effect on lifespan in C. elegans. Dur study suggests that Artemisia annua can be used for the development of novel natural therapeutics for diseases caused by environmental stressors. 2016 artículo científico 0101-2061 https://www.redalyc.org/articulo.oa?id=395946786021 en http://www.redalyc.org/revista.oa?id=3959 Ciência e Tecnologia de Alimentos application/pdf Sociedade Brasileira de Ciência e Tecnologia de Alimentos Ciência e Tecnologia de Alimentos (Brasil) Num.2 Vol.36 |
| title | Artemisia annua increases resistance to heat and oxidative stresses, but has no effect on lifespan in Caenorhabditis elegans |
| topic | Agrociencias elegans lifespan heat stress Artemisia annua oxidative stress |
| url | https://www.redalyc.org/articulo.oa?id=395946786021 |