Effects of puerarin on blood lipids and inflammatory factors in rats with lower limb arteriosclerosis obliterans
Fuente:
Redalyc
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Artículo científico |
| Sprache: | en |
| Veröffentlicht: |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos
2017
|
| Schlagworte: | |
| Online-Zugang: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1876445674806968320 |
|---|---|
| author | Bo LI |
| author_facet | Bo LI |
| contents | Effects of puerarin on blood lipids and inflammatory factors in rats with lower limb arteriosclerosis obliterans Bo LI Shiqi WEN Quan CHEN Qibing NIU Fang DONG Wanli SUN Junjun DU Agrociencias Puerarin Puerarin lower limb lower limb blood lipid This study investigated the effects of puerarin (PUE) on blood lipid and inflammatory factor levels in rats with lower limb arteriosclerosis obliterans (ASD). Sixty rats were randomly divided into control, model, simvastatin, low-PUE, middle-PUE and high-dose PUE group. The animals in later 5 groups were with lower limb ASD , and the later 4 groups were given 1 mg/kg simvastatin and 5, 10 and 20 mg/kg PUE, respectively. The blood lipid and inflammatory factor levels were determined. Results showed that, the serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP) level in model group were significantly increased (P <0.01), while the high-density lipoprotein cholesterol (HDL-C) was significantly decreased (P <0.01). Compared with model group, TC, TG, LDL-C, IL-6, TNF-α and hs-CRP in high-dose PUE and simvastatin group were significantly decreased (P <0.01 or P <0.05), and HDL level was significantly increased (P <0.01 or P <0.05). There was no significant difference of each index between simvastatin and high-dose PUE group (P >0.05). PUE can obviously decrease the blood lipid and inflammatory factor levels in rats with lower limb ASD . 2017 artículo científico 0101-2061 https://www.redalyc.org/articulo.oa?id=395953591024 en http://www.redalyc.org/revista.oa?id=3959 Ciência e Tecnologia de Alimentos application/pdf Sociedade Brasileira de Ciência e Tecnologia de Alimentos Ciência e Tecnologia de Alimentos (Brasil) Num.1 Vol.37 |
| format | Artículo científico |
| id | redalyc_395953591024 |
| institution | Redalyc |
| language | en |
| publishDate | 2017 |
| publisher | Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
| spellingShingle | Effects of puerarin on blood lipids and inflammatory factors in rats with lower limb arteriosclerosis obliterans Bo LI Agrociencias Puerarin Puerarin lower limb lower limb blood lipid Effects of puerarin on blood lipids and inflammatory factors in rats with lower limb arteriosclerosis obliterans Bo LI Shiqi WEN Quan CHEN Qibing NIU Fang DONG Wanli SUN Junjun DU Agrociencias Puerarin Puerarin lower limb lower limb blood lipid This study investigated the effects of puerarin (PUE) on blood lipid and inflammatory factor levels in rats with lower limb arteriosclerosis obliterans (ASD). Sixty rats were randomly divided into control, model, simvastatin, low-PUE, middle-PUE and high-dose PUE group. The animals in later 5 groups were with lower limb ASD , and the later 4 groups were given 1 mg/kg simvastatin and 5, 10 and 20 mg/kg PUE, respectively. The blood lipid and inflammatory factor levels were determined. Results showed that, the serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP) level in model group were significantly increased (P <0.01), while the high-density lipoprotein cholesterol (HDL-C) was significantly decreased (P <0.01). Compared with model group, TC, TG, LDL-C, IL-6, TNF-α and hs-CRP in high-dose PUE and simvastatin group were significantly decreased (P <0.01 or P <0.05), and HDL level was significantly increased (P <0.01 or P <0.05). There was no significant difference of each index between simvastatin and high-dose PUE group (P >0.05). PUE can obviously decrease the blood lipid and inflammatory factor levels in rats with lower limb ASD . 2017 artículo científico 0101-2061 https://www.redalyc.org/articulo.oa?id=395953591024 en http://www.redalyc.org/revista.oa?id=3959 Ciência e Tecnologia de Alimentos application/pdf Sociedade Brasileira de Ciência e Tecnologia de Alimentos Ciência e Tecnologia de Alimentos (Brasil) Num.1 Vol.37 |
| title | Effects of puerarin on blood lipids and inflammatory factors in rats with lower limb arteriosclerosis obliterans |
| topic | Agrociencias Puerarin Puerarin lower limb lower limb blood lipid |
| url | https://www.redalyc.org/articulo.oa?id=395953591024 |