IL-10 and ET-1 as biomarkers of rheumatic valve disease
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| Format: | Artículo científico |
| Langue: | en |
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Sociedade Brasileira de Cirurgia Cardiovascular
2014
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| _version_ | 1876465366023012352 |
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| author | Sydney Correia Leão |
| author_facet | Sydney Correia Leão |
| contents | IL-10 and ET-1 as biomarkers of rheumatic valve disease Sydney Correia Leão Maria Regina Menezes Lima Hertaline Menezes do Nascimento Shirlei Octacilio-Silva Tania Maria de Andrade Rodrigues Medicina Tu Endothelin mor Necrosis Factor Mitral Valve Stenosis Objective: To evaluate the immunological profile and gene expression of endothelin-1 (ET-1) in mitral valves of patients with rheumatic fever originated from a reference service in car - diovascular surgery. Methods: This was a quantitative, observational and cross-sec - tional study. Thirty-five subjects (divided into four groups) par - ticipated in the study, 25 patients with chronic rheumatic heart disease and ten control subjects. The mean age of the sample studied was 34.5 years. Seventeen of them (48.58%) were male and 18 (51.42%) were female. Inflammatory cytokines (TNF- α , IL-4 and IL-10) were measured and ten mitral valves of patients who underwent first valve replacement were collected for deter - mination of gene expression of endothelin-1 by real time PCR. Results: Among the groups studied (patients vs. controls), there was a statistically significant difference in IL-10 levels ( P =0.002), and no differences in other cytokines. Expression of endothelin-1 was observed in 70% of samples. Quantitatively, average of ET-1 expression was 62.85±25.63%. Conclusion: Inflammatory cytokine IL-10 participates in the maintenance of chronicity of rheumatic fever in patients who underwent valve replacement and those who are under - going medical treatment. The expression of endothelin-1 in heart valve lesions in patients undergoing mitral valve re - placement confirms its association with inflammatory activi - ty in rheumatic fever. Descriptors: Interleukin-10. Interleukin-4. R 2014 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398941892007 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.1 Vol.29 |
| format | Artículo científico |
| id | redalyc_398941892007 |
| institution | Redalyc |
| language | en |
| publishDate | 2014 |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| spellingShingle | IL-10 and ET-1 as biomarkers of rheumatic valve disease Sydney Correia Leão Medicina Tu Endothelin mor Necrosis Factor Mitral Valve Stenosis IL-10 and ET-1 as biomarkers of rheumatic valve disease Sydney Correia Leão Maria Regina Menezes Lima Hertaline Menezes do Nascimento Shirlei Octacilio-Silva Tania Maria de Andrade Rodrigues Medicina Tu Endothelin mor Necrosis Factor Mitral Valve Stenosis Objective: To evaluate the immunological profile and gene expression of endothelin-1 (ET-1) in mitral valves of patients with rheumatic fever originated from a reference service in car - diovascular surgery. Methods: This was a quantitative, observational and cross-sec - tional study. Thirty-five subjects (divided into four groups) par - ticipated in the study, 25 patients with chronic rheumatic heart disease and ten control subjects. The mean age of the sample studied was 34.5 years. Seventeen of them (48.58%) were male and 18 (51.42%) were female. Inflammatory cytokines (TNF- α , IL-4 and IL-10) were measured and ten mitral valves of patients who underwent first valve replacement were collected for deter - mination of gene expression of endothelin-1 by real time PCR. Results: Among the groups studied (patients vs. controls), there was a statistically significant difference in IL-10 levels ( P =0.002), and no differences in other cytokines. Expression of endothelin-1 was observed in 70% of samples. Quantitatively, average of ET-1 expression was 62.85±25.63%. Conclusion: Inflammatory cytokine IL-10 participates in the maintenance of chronicity of rheumatic fever in patients who underwent valve replacement and those who are under - going medical treatment. The expression of endothelin-1 in heart valve lesions in patients undergoing mitral valve re - placement confirms its association with inflammatory activi - ty in rheumatic fever. Descriptors: Interleukin-10. Interleukin-4. R 2014 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398941892007 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.1 Vol.29 |
| title | IL-10 and ET-1 as biomarkers of rheumatic valve disease |
| topic | Medicina Tu Endothelin mor Necrosis Factor Mitral Valve Stenosis |
| url | https://www.redalyc.org/articulo.oa?id=398941892007 |