Saved in:
| Main Author: | |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Sociedade Brasileira de Cirurgia Cardiovascular
2014
|
| Subjects: | |
| Online Access: | https://www.redalyc.org/articulo.oa?id=398941892007 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- IL-10 and ET-1 as biomarkers of rheumatic valve disease Sydney Correia Leão Maria Regina Menezes Lima Hertaline Menezes do Nascimento Shirlei Octacilio-Silva Tania Maria de Andrade Rodrigues Medicina Tu Endothelin mor Necrosis Factor Mitral Valve Stenosis Objective: To evaluate the immunological profile and gene expression of endothelin-1 (ET-1) in mitral valves of patients with rheumatic fever originated from a reference service in car - diovascular surgery. Methods: This was a quantitative, observational and cross-sec - tional study. Thirty-five subjects (divided into four groups) par - ticipated in the study, 25 patients with chronic rheumatic heart disease and ten control subjects. The mean age of the sample studied was 34.5 years. Seventeen of them (48.58%) were male and 18 (51.42%) were female. Inflammatory cytokines (TNF- α , IL-4 and IL-10) were measured and ten mitral valves of patients who underwent first valve replacement were collected for deter - mination of gene expression of endothelin-1 by real time PCR. Results: Among the groups studied (patients vs. controls), there was a statistically significant difference in IL-10 levels ( P =0.002), and no differences in other cytokines. Expression of endothelin-1 was observed in 70% of samples. Quantitatively, average of ET-1 expression was 62.85±25.63%. Conclusion: Inflammatory cytokine IL-10 participates in the maintenance of chronicity of rheumatic fever in patients who underwent valve replacement and those who are under - going medical treatment. The expression of endothelin-1 in heart valve lesions in patients undergoing mitral valve re - placement confirms its association with inflammatory activi - ty in rheumatic fever. Descriptors: Interleukin-10. Interleukin-4. R 2014 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398941892007 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.1 Vol.29