Myocardial regeneration after implantation of porcine small intestinal submucosa in the left ventricle
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Sociedade Brasileira de Cirurgia Cardiovascular
2014
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| _version_ | 1876438094432960512 |
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| author | Cassiana Maria Garcez Ramos |
| author_facet | Cassiana Maria Garcez Ramos |
| contents | Myocardial regeneration after implantation of porcine small intestinal submucosa in the left ventricle Cassiana Maria Garcez Ramos Julio César Francisco Marcia Olandoski Katherine Athayde Teixeira de Carvalho Ricardo Cunha Bruna Olandoski Erbano Lianna Ferrari Jorge Cristina Pellegrino Baena Vivian Ferreira do Amaral Lucia Noronha Rafael Michel de Macedo José Rocha Faria-Neto Luiz César Guarita-Souza Medicina Myocardium Regeneration Intestinal Mucosa ntroduction: Most cardiomyocytes do not regenerate after myocardial infarction. Porcine small intestinal submucosa has been shown to be effective in tissue repair. Objective: To evaluate myocardial tissue regeneration and func - tional effects of SIS implantation in pigs after left ventriculotomy. Methods: Fifteen pigs were assigned to two groups: porcine small intestinal submucosa (SIS) (N=10) and control (N=5). The SIS group underwent a mini sternotomy, left ventriculotomy and placement of a SIS patch. The control group underwent a sham procedure. Echocardiography was performed before and 60 days after the surgical procedure. Histological analysis was performed with hematoxylin-eosin stain and markers for actin 1A4, anti sarcomeric actin, connexin43 and factor VIII. Results: Weight gain was similar in both groups. Echocardiog - raphy analysis revealed no difference between groups regarding end diastolic and systolic diameters and left ventricular ejection fraction, both pre ( P =0.118, P =0.313, P =0.944) and post procedure ( P =0.333, P =0.522, P =0.628). Both groups showed an increase in end diastolic ( P <0,001 for both) and systolic diameter 60 days after surgery (P=0.005, SIS group and P =0.004, control group). New cardiomyocytes, blood vessels and inflammatory reactions were histologically identified in the SIS group. Conclusion: SIS implantation in pigs after left ventriculotomy was associated with angiomuscular regeneration and no damage in cardiac function. 2014 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398941893014 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.2 Vol.29 |
| format | Artículo científico |
| id | redalyc_398941893014 |
| institution | Redalyc |
| language | en |
| publishDate | 2014 |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| spellingShingle | Myocardial regeneration after implantation of porcine small intestinal submucosa in the left ventricle Cassiana Maria Garcez Ramos Medicina Myocardium Regeneration Intestinal Mucosa Myocardial regeneration after implantation of porcine small intestinal submucosa in the left ventricle Cassiana Maria Garcez Ramos Julio César Francisco Marcia Olandoski Katherine Athayde Teixeira de Carvalho Ricardo Cunha Bruna Olandoski Erbano Lianna Ferrari Jorge Cristina Pellegrino Baena Vivian Ferreira do Amaral Lucia Noronha Rafael Michel de Macedo José Rocha Faria-Neto Luiz César Guarita-Souza Medicina Myocardium Regeneration Intestinal Mucosa ntroduction: Most cardiomyocytes do not regenerate after myocardial infarction. Porcine small intestinal submucosa has been shown to be effective in tissue repair. Objective: To evaluate myocardial tissue regeneration and func - tional effects of SIS implantation in pigs after left ventriculotomy. Methods: Fifteen pigs were assigned to two groups: porcine small intestinal submucosa (SIS) (N=10) and control (N=5). The SIS group underwent a mini sternotomy, left ventriculotomy and placement of a SIS patch. The control group underwent a sham procedure. Echocardiography was performed before and 60 days after the surgical procedure. Histological analysis was performed with hematoxylin-eosin stain and markers for actin 1A4, anti sarcomeric actin, connexin43 and factor VIII. Results: Weight gain was similar in both groups. Echocardiog - raphy analysis revealed no difference between groups regarding end diastolic and systolic diameters and left ventricular ejection fraction, both pre ( P =0.118, P =0.313, P =0.944) and post procedure ( P =0.333, P =0.522, P =0.628). Both groups showed an increase in end diastolic ( P <0,001 for both) and systolic diameter 60 days after surgery (P=0.005, SIS group and P =0.004, control group). New cardiomyocytes, blood vessels and inflammatory reactions were histologically identified in the SIS group. Conclusion: SIS implantation in pigs after left ventriculotomy was associated with angiomuscular regeneration and no damage in cardiac function. 2014 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398941893014 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.2 Vol.29 |
| title | Myocardial regeneration after implantation of porcine small intestinal submucosa in the left ventricle |
| topic | Medicina Myocardium Regeneration Intestinal Mucosa |
| url | https://www.redalyc.org/articulo.oa?id=398941893014 |