Saved in:
| Main Author: | |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Sociedade Brasileira de Cirurgia Cardiovascular
2015
|
| Subjects: | |
| Online Access: | https://www.redalyc.org/articulo.oa?id=398941897007 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- Effect of N-acetylcysteine in hearts of rats submitted to controlled hemorrhagic shock Luiz Dantas de Oliveira Filho Karen Ruggeri Saad Paulo Fernandes Saad Marcia Kiyomi Koike Sônia Maria da Silva Edna Frasson de Souza Montero Medicina Shock Heart Hemorrhagic Inflammation Acetylcysteine Introduction: Pharmacological therapy is a strategy for the prevention of complications associated with ischemia and reper - fusion injury that occurs after volume replacement in the treat - ment of hemorrhagic shock. Objective: The aim of this study was to evaluate the effect of N-acetylcysteine associated with fluid resuscitation in cardiac injury in a rat hemorrhagic shock model. Methods: Mice Wister male rats were randomly and sub - jected to controlled hemorrhagic shock for 60 min. and then, subjected to resuscitation with Ringer lactate. In a group of six animals, 150mg/kg of N-acetylcysteine were added to fluid vol - ume replacement. The animals were observed for 120 min and after this period, were euthanized and cardiac tissue was col - lected for histopathological analysis and measurement of thio - barbituric acid reactive substances and pro-and anti-inflamma - tory interleukin. Results: Cardiac tissue of the group treated with N-acetyl - cysteine showed lower concentrations of thiobarbituric acid reactive substances (0.20±0.05 vs. 0.27±0.05, P =0.014) and re - duced histopathological damage and edema when compared to the group whose volume replacement occurred only with Ringer lactate. There was no difference in the expression of cytokines interleukin 6 (2,138.29±316.89 vs. 1,870.16±303.68, P =0.091) and interleukin 10 (1.019,83±262,50 vs. 848.60±106.5, P =0.169) between the treated groups. Conclusion: The association of N-acetylcysteine on volume replacement attenuates oxidative stress in the heart, as well myocardial damage and edema, but does not modify the expres - sion of inflammatory cytokines. 2015 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398941897007 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.2 Vol.30