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| Format: | Artículo científico |
| Language: | en |
| Published: |
Sociedade Brasileira de Cirurgia Cardiovascular
2015
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| Online Access: | https://www.redalyc.org/articulo.oa?id=398941897019 |
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Table of Contents:
- Effects of ischemia and omeprazole preconditioning on functional recovery of isolated rat heart Nevena Jeremic Anica Petkovic Ivan Srejovic Vladimir Zivkovic Dragan Djuric Vladimir Jakovljevic Medicina Myocardial Omeprazole Coronary circulation Ischemic Preconditionng Objective: The aim of this study was to compare protective effects of ischemic and potential protective effects of pharma - cological preconditioning with omeprazole on isolated rat heart subjected to ischemia/reperfusion. Methods: The hearts of male Wistar albino rats were excised and perfused on a Langendorff apparatus. In control group (CG) after stabilization period, hearts were subjected to global ischemia (perfusion was totally stopped) for 20 minutes and 30 minutes of reperfusion. Hearts of group II (IPC) were submit - ted to ischemic preconditioning lasting 5 minutes before 20 min - utes of ischemia and 30 minutes of reperfusion. In third group (OPC) hearts first underwent preconditioning lasting 5 minutes with 100μM omeprazole, and then submitted 20 minutes of isch - emia and 30 minutes of reperfusion. Results: Administration of omeprazole before ischemia in - duction had protective effect on myocardium function recovery especially regarding to values of systolic left ventricular pressu - re and dp/dt max. Also our findings are that values of coronary flow did not change between OPC and IPC groups in last point of reperfusion. Conclusion: Based on our results it seems that ischemic pre - conditioning could be used as first window of protection after ischemic injury especially because all investigated parameters showed continuous trend of recovery of myocardial function. On the other hand, preconditioning with omeprazole induced sudden trend of recovery with positive myocardium protection, although less effective than results obtained with ischemic pre - conditioning not withstand, we must consider that omeprazole may be used in many clinical circumstances where direct coro - nary clamping for ischemic preconditioning is not possible. 2015 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398941897019 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.2 Vol.30