Evaluation of Pulmonary Reperfusion Injury in Rats Undergoing Mesenteric Ischemia and Reperfusion and Protective Effect of Postconditioning on this Process
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Sociedade Brasileira de Cirurgia Cardiovascular
2015
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| _version_ | 1876475734163193856 |
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| author | Carlos Henrique Marques dos Santos |
| author_facet | Carlos Henrique Marques dos Santos |
| contents | Evaluation of Pulmonary Reperfusion Injury in Rats Undergoing Mesenteric Ischemia and Reperfusion and Protective Effect of Postconditioning on this Process Carlos Henrique Marques dos Santos Ricardo Dutra Aydos Ed Nogueira Neto Luciana Nakao Odashiro Miiji Pedro Carvalho Cassino Isadora Ishaq Alves Nádia Meneguesso Calheiros Milena Garcia Medicina Ischemia Lung Injury Intestinal Mucosa Reperfusion Injury Ischemic Postconditioning Introduction: Some publications have demonstrated thepresence of lung reperfusion injury in mesenteric ischemia andreperfusion (I/R), but under to diverse methods. Postconditioninghas been recognized as effective in preventing reperfusion injuryin various organs and tissues. However, its effectiveness has notbeen evaluated in the prevention of lung reperfusion injury aftermesenteric ischemia and reperfusion.Objective: To evaluate the presence of pulmonary reperfusioninjury and the protective effect of ischemic postconditioning onlung parenchyma in rats submitted to mesenteric ischemia andreperfusion.Methods: Thirty Wistar rats were distributed into threegroups: group A (10 rats), which was held mesenteric ischemia (30minutes) and reperfusion (60 minutes); group B (10 rats), ischemiaand reperfusion, interspersed by postconditioning with twoalternating cycles of reperfusion and reocclusion, for two minuteseach; and group C (10 rats), ischemia and reperfusion interleavedby postconditioning with four alternating cycles of reperfusionand reocclusion of 30 seconds each. Finally, it was resected theupper lung lobe for histological analysis.Results: There were mild lung lesions (grade 1) in all samples.There was no statistical difference between groups 1 and 2 (P>0.05).Conclusion: The mesenteric ischemia and reperfusion in ratsfor thirty and sixty minutes, respectively, caused mild reperfusioninjury in lung. Postconditioning was not able to minimize theremote reperfusion injury and there was no difference comparingtwo cycles of two minutes with four cycles of 30 seconds. 2015 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398943520005 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.5 Vol.30 |
| format | Artículo científico |
| id | redalyc_398943520005 |
| institution | Redalyc |
| language | en |
| publishDate | 2015 |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| spellingShingle | Evaluation of Pulmonary Reperfusion Injury in Rats Undergoing Mesenteric Ischemia and Reperfusion and Protective Effect of Postconditioning on this Process Carlos Henrique Marques dos Santos Medicina Ischemia Lung Injury Intestinal Mucosa Reperfusion Injury Ischemic Postconditioning Evaluation of Pulmonary Reperfusion Injury in Rats Undergoing Mesenteric Ischemia and Reperfusion and Protective Effect of Postconditioning on this Process Carlos Henrique Marques dos Santos Ricardo Dutra Aydos Ed Nogueira Neto Luciana Nakao Odashiro Miiji Pedro Carvalho Cassino Isadora Ishaq Alves Nádia Meneguesso Calheiros Milena Garcia Medicina Ischemia Lung Injury Intestinal Mucosa Reperfusion Injury Ischemic Postconditioning Introduction: Some publications have demonstrated thepresence of lung reperfusion injury in mesenteric ischemia andreperfusion (I/R), but under to diverse methods. Postconditioninghas been recognized as effective in preventing reperfusion injuryin various organs and tissues. However, its effectiveness has notbeen evaluated in the prevention of lung reperfusion injury aftermesenteric ischemia and reperfusion.Objective: To evaluate the presence of pulmonary reperfusioninjury and the protective effect of ischemic postconditioning onlung parenchyma in rats submitted to mesenteric ischemia andreperfusion.Methods: Thirty Wistar rats were distributed into threegroups: group A (10 rats), which was held mesenteric ischemia (30minutes) and reperfusion (60 minutes); group B (10 rats), ischemiaand reperfusion, interspersed by postconditioning with twoalternating cycles of reperfusion and reocclusion, for two minuteseach; and group C (10 rats), ischemia and reperfusion interleavedby postconditioning with four alternating cycles of reperfusionand reocclusion of 30 seconds each. Finally, it was resected theupper lung lobe for histological analysis.Results: There were mild lung lesions (grade 1) in all samples.There was no statistical difference between groups 1 and 2 (P>0.05).Conclusion: The mesenteric ischemia and reperfusion in ratsfor thirty and sixty minutes, respectively, caused mild reperfusioninjury in lung. Postconditioning was not able to minimize theremote reperfusion injury and there was no difference comparingtwo cycles of two minutes with four cycles of 30 seconds. 2015 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398943520005 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.5 Vol.30 |
| title | Evaluation of Pulmonary Reperfusion Injury in Rats Undergoing Mesenteric Ischemia and Reperfusion and Protective Effect of Postconditioning on this Process |
| topic | Medicina Ischemia Lung Injury Intestinal Mucosa Reperfusion Injury Ischemic Postconditioning |
| url | https://www.redalyc.org/articulo.oa?id=398943520005 |