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| Format: | Artículo científico |
| Language: | en |
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Sociedade Brasileira de Cirurgia Cardiovascular
2015
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| Online Access: | https://www.redalyc.org/articulo.oa?id=398943520006 |
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Table of Contents:
- Adjunctive Hyperbaric Oxygen Therapy or Alone Antibiotherapy? Methicillin Resistant Staphylococcus aureus Mediastinitis in a Rat Model Tolga Kurt Ahmet Vural Ahmet Temiz Ersan Ozbudak Ali Umit Yener Suzan Sacar Mustafa Sacar Medicina Vancomycin Mediastinitis Hyperbaric Oxygenation Objective: In the post-sternotomy mediastinitis patients,Staphylococcus aureusis the pathogenic microorganismencountered most often. In our study, we aimed to determine theefficacy of antibiotic treatment with vancomycin and tigecycline,alone or in combination with hyperbaric oxygen treatment, onbacterial elimination in experimental S. aureus mediastinitis.Methods: Forty-nine adult female Wistar rats were used.They were randomly divided into seven groups, as follows: non-contaminated, contaminated control, vancomycin, tigecycline,hyperbaric oxygen, hyperbaric oxygen + vancomycin andhyperbaric oxygen + tigecycline. The vancomycin rat groupreceived 10 mg/kg/day of vancomycin twice a day throughintramuscular injection. The tigecycline group rats received7 mg/kg/day of tigecycline twice a day through intraperitonealinjection. The hyperbaric oxygen group underwent 90 minsessions of 100% oxygen at 2.5 atm pressure. Treatmentcontinued for 7 days. Twelve hours after the end of treatment,tissue samples were obtained from the upper part of the sternumfor bacterial count assessment.Results: When the quantitative bacterial counts of theuntreated contaminated group were compared with those of thetreated groups, a significant decrease was observed. However,comparing the antibiotic groups with the same antibiotic combinedwith hyperbaric oxygen, there was a significant reduction inmicroorganisms identified (P<0.05). Comparing hyperbaric oxygenused alone with the vancomycin and tigecycline groups, it wasseen that the effect was not significant (P<0.05).Conclusion: We believe that the combination of hyperbaricoxygen with antibiotics had a significant effect on mediastinitisresulting from methicillin-resistantStaphylococcus aureus.Methicillin-resistantStaphylococcus aureusmediastinitis canbe treated without requiring a multidrug combination, therebyreducing the medication dose and concomitantly decreasing theside effects. 2015 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398943520006 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.5 Vol.30