Effect of Ischemic Postconditioning and Atorvastatin in the Prevention of Remote Lung Reperfusion Injury
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Sociedade Brasileira de Cirurgia Cardiovascular
2018
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| _version_ | 1876486784792133632 |
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| author | Carlos Henrique Marques dos Santos |
| author_facet | Carlos Henrique Marques dos Santos |
| contents | Effect of Ischemic Postconditioning and Atorvastatin in the Prevention of Remote Lung Reperfusion Injury Carlos Henrique Marques dos Santos Doroty Mesquita Dourado Baldomero Antonio Kato da Silva Henrique Budib Dorsa Pontes Euler de Azevedo Giovanna Serra da Cruz Vendas Ian de Oliveira Chaves João Victor Cunha Miranda João Victor Durães Gomes Oliva Letícia do Espírito Santo Dias Murillo Henrique Martins de Almeida Trícia Luna Sampaio Medicina Lung Ischemia Reperfusion Injury Hydroxymethylglutaryl CoA Reductase Inhibitors Objective: The aim of the present study was to evaluate the ability of ischemic postconditioning, atorvastatin and both associated to prevent or minimize reperfusion injury in the lung of rats subjected to ischemia and reperfusion by abdominal aortic clamping.Methods: We used 41 Wistar norvegic rats, which were distributed into 5 groups: ischemia and reperfusion (I/R), ischemic postcondictioning (IPC), postconditioning + atorvastatin (IPC+A), atorvastatin (A) and SHAM. It was performed a medium laparotomy, dissection and isolation of the infra-renal abdominal aorta; except for the SHAM group, all the others were submitted to the aortic clamping for 70 minutes (ischemia) and posterior clamp removal (reperfusion, 70 minutes). In the IPC and IPC+A groups, postconditioning was performed between the ischemia and reperfusion phases by four cycles of reperfusion and ischemia lasting 30 seconds each. In the IPC+A and A groups, preceding the surgical procedure, administration of 3.4 mg/day of atorvastatin was performed for seven days by gavage. After the surgical procedure, the right caudal lobe was removed from the lung for histological study, using tissue injury score ranging from grade 1 (normal tissue) to grade 4 (intense lesion).Results: The mean lung injury was 3.6 in the I/R group, 1.6 in the IPC group, 1.2 in the IPC+A group, 1.2 in the A group, and 1 in the SHAM group (P<0.01).Conclusion: Ischemic postconditioning and atorvastatin were able to minimize lung reperfusion injury, alone or in combination. 2018 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398955542003 https://www.redalyc.org/journal/3989/398955542003/ https://www.redalyc.org/journal/3989/398955542003/html/ https://www.redalyc.org/journal/3989/398955542003/398955542003.epub https://www.redalyc.org/journal/3989/398955542003/movil 10.21470/1678-9741-2017-0022 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.2 Vol.33 |
| format | Artículo científico |
| id | redalyc_398955542003 |
| institution | Redalyc |
| language | en |
| publishDate | 2018 |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| spellingShingle | Effect of Ischemic Postconditioning and Atorvastatin in the Prevention of Remote Lung Reperfusion Injury Carlos Henrique Marques dos Santos Medicina Lung Ischemia Reperfusion Injury Hydroxymethylglutaryl CoA Reductase Inhibitors Effect of Ischemic Postconditioning and Atorvastatin in the Prevention of Remote Lung Reperfusion Injury Carlos Henrique Marques dos Santos Doroty Mesquita Dourado Baldomero Antonio Kato da Silva Henrique Budib Dorsa Pontes Euler de Azevedo Giovanna Serra da Cruz Vendas Ian de Oliveira Chaves João Victor Cunha Miranda João Victor Durães Gomes Oliva Letícia do Espírito Santo Dias Murillo Henrique Martins de Almeida Trícia Luna Sampaio Medicina Lung Ischemia Reperfusion Injury Hydroxymethylglutaryl CoA Reductase Inhibitors Objective: The aim of the present study was to evaluate the ability of ischemic postconditioning, atorvastatin and both associated to prevent or minimize reperfusion injury in the lung of rats subjected to ischemia and reperfusion by abdominal aortic clamping.Methods: We used 41 Wistar norvegic rats, which were distributed into 5 groups: ischemia and reperfusion (I/R), ischemic postcondictioning (IPC), postconditioning + atorvastatin (IPC+A), atorvastatin (A) and SHAM. It was performed a medium laparotomy, dissection and isolation of the infra-renal abdominal aorta; except for the SHAM group, all the others were submitted to the aortic clamping for 70 minutes (ischemia) and posterior clamp removal (reperfusion, 70 minutes). In the IPC and IPC+A groups, postconditioning was performed between the ischemia and reperfusion phases by four cycles of reperfusion and ischemia lasting 30 seconds each. In the IPC+A and A groups, preceding the surgical procedure, administration of 3.4 mg/day of atorvastatin was performed for seven days by gavage. After the surgical procedure, the right caudal lobe was removed from the lung for histological study, using tissue injury score ranging from grade 1 (normal tissue) to grade 4 (intense lesion).Results: The mean lung injury was 3.6 in the I/R group, 1.6 in the IPC group, 1.2 in the IPC+A group, 1.2 in the A group, and 1 in the SHAM group (P<0.01).Conclusion: Ischemic postconditioning and atorvastatin were able to minimize lung reperfusion injury, alone or in combination. 2018 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398955542003 https://www.redalyc.org/journal/3989/398955542003/ https://www.redalyc.org/journal/3989/398955542003/html/ https://www.redalyc.org/journal/3989/398955542003/398955542003.epub https://www.redalyc.org/journal/3989/398955542003/movil 10.21470/1678-9741-2017-0022 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.2 Vol.33 |
| title | Effect of Ischemic Postconditioning and Atorvastatin in the Prevention of Remote Lung Reperfusion Injury |
| topic | Medicina Lung Ischemia Reperfusion Injury Hydroxymethylglutaryl CoA Reductase Inhibitors |
| url | https://www.redalyc.org/articulo.oa?id=398955542003 https://www.redalyc.org/journal/3989/398955542003/ https://www.redalyc.org/journal/3989/398955542003/html/ https://www.redalyc.org/journal/3989/398955542003/398955542003.epub https://www.redalyc.org/journal/3989/398955542003/movil |