Protective Effects of Baicalin on Experimental Myocardial Infarction in Rats
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| Natura: | Artículo científico |
| Lingua: | en |
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Sociedade Brasileira de Cirurgia Cardiovascular
2018
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| _version_ | 1876466598283313152 |
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| author | Longfei Wang |
| author_facet | Longfei Wang |
| contents | Protective Effects of Baicalin on Experimental Myocardial Infarction in Rats Longfei Wang Yong Li Shenglan Lin Zhiqiang Pu Haiping Li Zhili Tang Medicina Bcl Flavonoids Oxidative Stress Associated x Protein Myocardial Infarction Objective: This study aimed to investigate the protective effects of baicalin on myocardial infarction in rats and explore the related mechanisms.Methods: Fifty Sprague Dawley rats were randomly divided into the control, model, and low-, medium- and high-dose baicalin groups. The latter 3 groups were intraperitoneally injected with baicalin, with a dose of 12.5, 25 and 50 mg/kg, respectively. Then, the myocardial infarction model was established. The hemodynamic of rats was tested, the serum lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), prostacyclin (PGI2) and thromboxane A2 (TXA2) were determined, the myocardial superoxide dismutase (SOD) and malondialdehyde (MDA) levels were detected, and the myocardial B-cell lymphoma-2 (Bcl-2) and Bcl-2 associated X (Bax) protein expressions were determined.Results: Compared with the model group, in the high-dose baicalin group the ST segment height and LVEDP were significantly decreased (P<0.05), the LVSP was significantly increased (P<0.05), the serum LDH, CK-MB and TXA2 levels were significantly decreased (P<0.05), the PGI2 level was significantly increased (P<0.05), the myocardial SOD level was significantly increased (P<0.05), and the myocardial MDA level was significantly decreased (P<0.05); the myocardial Bcl-2 protein level was significantly increased, and the Bax protein level was significantly decreased (P<0.05).Conclusion: Baicalin has protective effects on myocardial infarction in rats. The possible mechanisms may be related to its resistance to oxidative stress, and up-regulation of Bcl-2 protein expression and down-regulation of Bax protein expression in myocardial tissue. 2018 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398956442012 https://www.redalyc.org/journal/3989/398956442012/ https://www.redalyc.org/journal/3989/398956442012/html/ https://www.redalyc.org/journal/3989/398956442012/398956442012.epub https://www.redalyc.org/journal/3989/398956442012/movil 10.21470/1678-9741-2018-0059 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.4 Vol.33 |
| format | Artículo científico |
| id | redalyc_398956442012 |
| institution | Redalyc |
| language | en |
| publishDate | 2018 |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| spellingShingle | Protective Effects of Baicalin on Experimental Myocardial Infarction in Rats Longfei Wang Medicina Bcl Flavonoids Oxidative Stress Associated x Protein Myocardial Infarction Protective Effects of Baicalin on Experimental Myocardial Infarction in Rats Longfei Wang Yong Li Shenglan Lin Zhiqiang Pu Haiping Li Zhili Tang Medicina Bcl Flavonoids Oxidative Stress Associated x Protein Myocardial Infarction Objective: This study aimed to investigate the protective effects of baicalin on myocardial infarction in rats and explore the related mechanisms.Methods: Fifty Sprague Dawley rats were randomly divided into the control, model, and low-, medium- and high-dose baicalin groups. The latter 3 groups were intraperitoneally injected with baicalin, with a dose of 12.5, 25 and 50 mg/kg, respectively. Then, the myocardial infarction model was established. The hemodynamic of rats was tested, the serum lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), prostacyclin (PGI2) and thromboxane A2 (TXA2) were determined, the myocardial superoxide dismutase (SOD) and malondialdehyde (MDA) levels were detected, and the myocardial B-cell lymphoma-2 (Bcl-2) and Bcl-2 associated X (Bax) protein expressions were determined.Results: Compared with the model group, in the high-dose baicalin group the ST segment height and LVEDP were significantly decreased (P<0.05), the LVSP was significantly increased (P<0.05), the serum LDH, CK-MB and TXA2 levels were significantly decreased (P<0.05), the PGI2 level was significantly increased (P<0.05), the myocardial SOD level was significantly increased (P<0.05), and the myocardial MDA level was significantly decreased (P<0.05); the myocardial Bcl-2 protein level was significantly increased, and the Bax protein level was significantly decreased (P<0.05).Conclusion: Baicalin has protective effects on myocardial infarction in rats. The possible mechanisms may be related to its resistance to oxidative stress, and up-regulation of Bcl-2 protein expression and down-regulation of Bax protein expression in myocardial tissue. 2018 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398956442012 https://www.redalyc.org/journal/3989/398956442012/ https://www.redalyc.org/journal/3989/398956442012/html/ https://www.redalyc.org/journal/3989/398956442012/398956442012.epub https://www.redalyc.org/journal/3989/398956442012/movil 10.21470/1678-9741-2018-0059 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.4 Vol.33 |
| title | Protective Effects of Baicalin on Experimental Myocardial Infarction in Rats |
| topic | Medicina Bcl Flavonoids Oxidative Stress Associated x Protein Myocardial Infarction |
| url | https://www.redalyc.org/articulo.oa?id=398956442012 https://www.redalyc.org/journal/3989/398956442012/ https://www.redalyc.org/journal/3989/398956442012/html/ https://www.redalyc.org/journal/3989/398956442012/398956442012.epub https://www.redalyc.org/journal/3989/398956442012/movil |