Saved in:
| Main Author: | |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Sociedade Brasileira de Cirurgia Cardiovascular
2018
|
| Subjects: | |
| Online Access: | https://www.redalyc.org/articulo.oa?id=398956442012 https://www.redalyc.org/journal/3989/398956442012/ https://www.redalyc.org/journal/3989/398956442012/html/ https://www.redalyc.org/journal/3989/398956442012/398956442012.epub https://www.redalyc.org/journal/3989/398956442012/movil |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- Protective Effects of Baicalin on Experimental Myocardial Infarction in Rats Longfei Wang Yong Li Shenglan Lin Zhiqiang Pu Haiping Li Zhili Tang Medicina Bcl Flavonoids Oxidative Stress Associated x Protein Myocardial Infarction Objective: This study aimed to investigate the protective effects of baicalin on myocardial infarction in rats and explore the related mechanisms.Methods: Fifty Sprague Dawley rats were randomly divided into the control, model, and low-, medium- and high-dose baicalin groups. The latter 3 groups were intraperitoneally injected with baicalin, with a dose of 12.5, 25 and 50 mg/kg, respectively. Then, the myocardial infarction model was established. The hemodynamic of rats was tested, the serum lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), prostacyclin (PGI2) and thromboxane A2 (TXA2) were determined, the myocardial superoxide dismutase (SOD) and malondialdehyde (MDA) levels were detected, and the myocardial B-cell lymphoma-2 (Bcl-2) and Bcl-2 associated X (Bax) protein expressions were determined.Results: Compared with the model group, in the high-dose baicalin group the ST segment height and LVEDP were significantly decreased (P<0.05), the LVSP was significantly increased (P<0.05), the serum LDH, CK-MB and TXA2 levels were significantly decreased (P<0.05), the PGI2 level was significantly increased (P<0.05), the myocardial SOD level was significantly increased (P<0.05), and the myocardial MDA level was significantly decreased (P<0.05); the myocardial Bcl-2 protein level was significantly increased, and the Bax protein level was significantly decreased (P<0.05).Conclusion: Baicalin has protective effects on myocardial infarction in rats. The possible mechanisms may be related to its resistance to oxidative stress, and up-regulation of Bcl-2 protein expression and down-regulation of Bax protein expression in myocardial tissue. 2018 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398956442012 https://www.redalyc.org/journal/3989/398956442012/ https://www.redalyc.org/journal/3989/398956442012/html/ https://www.redalyc.org/journal/3989/398956442012/398956442012.epub https://www.redalyc.org/journal/3989/398956442012/movil 10.21470/1678-9741-2018-0059 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.4 Vol.33