Effects of in vitro Amitriptyline, Fluoxetine, Tranylcypromine and Venlafaxine on Saphenous Vein Grafts
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Sociedade Brasileira de Cirurgia Cardiovascular
2019
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| _version_ | 1876479166558240768 |
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| author | Melek Akinci |
| author_facet | Melek Akinci |
| contents | Effects of in vitro Amitriptyline, Fluoxetine, Tranylcypromine and Venlafaxine on Saphenous Vein Grafts Melek Akinci Cetin Hakan Karadag Serhat Huseyin Cagatay Oltulu Suat Canbaz Ozgur Gunduz Ruhan Deniz Topuz Medicina Fluoxetine Venlafaxine Amitriptyline Saphenous Vein Tranylcypromine Objective: In this study, we aimed to examine the effects of amitriptyline, fluoxetine, tranylcypromine and venlafaxine on saphenous vein grafts in coronary artery bypass graft surgeries.Methods: 59 patients (40 males and 19 females; mean age 65.1 years, distribution: 45-84 years) who had coronary artery bypass graft surgery between February 2014 and May 2016 were included in the study. After the saphenous vein grafts with intact and denuded endothelium were precontracted with 3×10-6M phenylephrine, amitriptyline, fluoxetine and tranylcypromine were cumulatively added to isolated organ baths in the range of 10-11-3x10-5M, while venlafaxine was added in the range of 10-9-3×10-5M. Then, the antidepressant-induced relaxation responses were recorded isometrically.Results: While the relaxation response of amitriptyline at -6.42 (Log M) was 74.6%, the response at -6.32 (Log M) was 75.5%. While the relaxation response at -6.46 (Log M) of fluoxetine was 68.02%, the response at -6.02 (Log M) was 72.12%. While the relaxation response of tranylcypromine at -7.53 (Log M) was 61.13%, the response at -7.23 (Log M) was 65.53%. While the relaxation response of venlafaxine at -6.21 (Log M) was 29.98%, the response at -5.90 (Log M) was 32.96%.Conclusion: The maximum relaxation at minimum and maximum therapeutic concentrations was obtained with amitriptyline, fluoxetine and tranylcypromine, and the minimum relaxation was obtained with venlafaxine. The relaxation responses were independent of the endothelium. 2019 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398960426007 https://www.redalyc.org/journal/3989/398960426007/ https://www.redalyc.org/journal/3989/398960426007/html/ https://www.redalyc.org/journal/3989/398960426007/398960426007.epub https://www.redalyc.org/journal/3989/398960426007/movil 10.21470/1678-9741-2018-0338 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.3 Vol.34 |
| format | Artículo científico |
| id | redalyc_398960426007 |
| institution | Redalyc |
| language | en |
| publishDate | 2019 |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| spellingShingle | Effects of in vitro Amitriptyline, Fluoxetine, Tranylcypromine and Venlafaxine on Saphenous Vein Grafts Melek Akinci Medicina Fluoxetine Venlafaxine Amitriptyline Saphenous Vein Tranylcypromine Effects of in vitro Amitriptyline, Fluoxetine, Tranylcypromine and Venlafaxine on Saphenous Vein Grafts Melek Akinci Cetin Hakan Karadag Serhat Huseyin Cagatay Oltulu Suat Canbaz Ozgur Gunduz Ruhan Deniz Topuz Medicina Fluoxetine Venlafaxine Amitriptyline Saphenous Vein Tranylcypromine Objective: In this study, we aimed to examine the effects of amitriptyline, fluoxetine, tranylcypromine and venlafaxine on saphenous vein grafts in coronary artery bypass graft surgeries.Methods: 59 patients (40 males and 19 females; mean age 65.1 years, distribution: 45-84 years) who had coronary artery bypass graft surgery between February 2014 and May 2016 were included in the study. After the saphenous vein grafts with intact and denuded endothelium were precontracted with 3×10-6M phenylephrine, amitriptyline, fluoxetine and tranylcypromine were cumulatively added to isolated organ baths in the range of 10-11-3x10-5M, while venlafaxine was added in the range of 10-9-3×10-5M. Then, the antidepressant-induced relaxation responses were recorded isometrically.Results: While the relaxation response of amitriptyline at -6.42 (Log M) was 74.6%, the response at -6.32 (Log M) was 75.5%. While the relaxation response at -6.46 (Log M) of fluoxetine was 68.02%, the response at -6.02 (Log M) was 72.12%. While the relaxation response of tranylcypromine at -7.53 (Log M) was 61.13%, the response at -7.23 (Log M) was 65.53%. While the relaxation response of venlafaxine at -6.21 (Log M) was 29.98%, the response at -5.90 (Log M) was 32.96%.Conclusion: The maximum relaxation at minimum and maximum therapeutic concentrations was obtained with amitriptyline, fluoxetine and tranylcypromine, and the minimum relaxation was obtained with venlafaxine. The relaxation responses were independent of the endothelium. 2019 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398960426007 https://www.redalyc.org/journal/3989/398960426007/ https://www.redalyc.org/journal/3989/398960426007/html/ https://www.redalyc.org/journal/3989/398960426007/398960426007.epub https://www.redalyc.org/journal/3989/398960426007/movil 10.21470/1678-9741-2018-0338 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.3 Vol.34 |
| title | Effects of in vitro Amitriptyline, Fluoxetine, Tranylcypromine and Venlafaxine on Saphenous Vein Grafts |
| topic | Medicina Fluoxetine Venlafaxine Amitriptyline Saphenous Vein Tranylcypromine |
| url | https://www.redalyc.org/articulo.oa?id=398960426007 https://www.redalyc.org/journal/3989/398960426007/ https://www.redalyc.org/journal/3989/398960426007/html/ https://www.redalyc.org/journal/3989/398960426007/398960426007.epub https://www.redalyc.org/journal/3989/398960426007/movil |