C-Reactive Protein to Albumin Ratio as A Novel Inflammatory-Based Marker for 30-Day Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement
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| Natura: | Artículo científico |
| Lingua: | en |
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Sociedade Brasileira de Cirurgia Cardiovascular
2022
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| author | Fahrettin Katkat |
| author_facet | Fahrettin Katkat |
| contents | C-Reactive Protein to Albumin Ratio as A Novel Inflammatory-Based Marker for 30-Day Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement Fahrettin Katkat Muhsin Kalyoncuoglu Sevgi Ozcan Sevil Tugrul Hanife Abanus Orhan Ince Mehmet Balli Irfan Sahin Ertugrul Okuyan Medicina Mortality Serum Albumin Aortic Stenosis Reactive Protein Transcatheter Aortic Valve Replacement Objective: We aimed to investigate whether C-reactive protein to albumin ratio (CAR) predicts the early and late mortality in patients undergoing transcatheter aortic valve replacement (TAVR).Methods: This study was retrospectively designed and includes 170 TAVR patients with a mean age of 78.4±7.1 years. Patients were divided into 2 groups as those who died and those who survived, taking into account the follow-up period. Complete blood count, serum CRP and serum albumin were obtained on admission. The CAR value of all patients was calculated and the relationship of CAR with early (≤30 days) and late mortality (>30 days) was evaluated.Results: The median follow-up period was 19 7-31 months (maximum 66 months). Early mortality was observed in 20 (11.8%) patients, whereas late mortality was observed in 39 (22.9%) patients, most of them male (61.1%, P=0.04). Non-survivors had greater CAR value, higher baseline serum CRP level and lower baseline albumin level than survivors (P<0.01, for all parameters). According to multivariate analysis models, CAR (HR: 1.020, P<0.01) and TVAR score (HR: 1.294, P<0.01) were found to be independent predictors of early mortality while CRP and albumin were not. The area under the curve (AUC) for CAR was 0.73 with a P <0.01. A CAR >15.6 predicted the early mortality with 80% sensitivity and 57% specificity.Conclusion: The novel inflammatory marker CAR can be used as a reliable marker in predicting 30-day mortality in patients undergoing TAVR. 2022 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398971282003 https://www.redalyc.org/journal/3989/398971282003/ https://www.redalyc.org/journal/3989/398971282003/html/ https://www.redalyc.org/journal/3989/398971282003/398971282003.epub https://www.redalyc.org/journal/3989/398971282003/movil 10.21470/1678-9741-2020-0482 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.3 Vol.37 |
| format | Artículo científico |
| id | redalyc_398971282003 |
| institution | Redalyc |
| language | en |
| publishDate | 2022 |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| spellingShingle | C-Reactive Protein to Albumin Ratio as A Novel Inflammatory-Based Marker for 30-Day Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement Fahrettin Katkat Medicina Mortality Serum Albumin Aortic Stenosis Reactive Protein Transcatheter Aortic Valve Replacement C-Reactive Protein to Albumin Ratio as A Novel Inflammatory-Based Marker for 30-Day Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement Fahrettin Katkat Muhsin Kalyoncuoglu Sevgi Ozcan Sevil Tugrul Hanife Abanus Orhan Ince Mehmet Balli Irfan Sahin Ertugrul Okuyan Medicina Mortality Serum Albumin Aortic Stenosis Reactive Protein Transcatheter Aortic Valve Replacement Objective: We aimed to investigate whether C-reactive protein to albumin ratio (CAR) predicts the early and late mortality in patients undergoing transcatheter aortic valve replacement (TAVR).Methods: This study was retrospectively designed and includes 170 TAVR patients with a mean age of 78.4±7.1 years. Patients were divided into 2 groups as those who died and those who survived, taking into account the follow-up period. Complete blood count, serum CRP and serum albumin were obtained on admission. The CAR value of all patients was calculated and the relationship of CAR with early (≤30 days) and late mortality (>30 days) was evaluated.Results: The median follow-up period was 19 7-31 months (maximum 66 months). Early mortality was observed in 20 (11.8%) patients, whereas late mortality was observed in 39 (22.9%) patients, most of them male (61.1%, P=0.04). Non-survivors had greater CAR value, higher baseline serum CRP level and lower baseline albumin level than survivors (P<0.01, for all parameters). According to multivariate analysis models, CAR (HR: 1.020, P<0.01) and TVAR score (HR: 1.294, P<0.01) were found to be independent predictors of early mortality while CRP and albumin were not. The area under the curve (AUC) for CAR was 0.73 with a P <0.01. A CAR >15.6 predicted the early mortality with 80% sensitivity and 57% specificity.Conclusion: The novel inflammatory marker CAR can be used as a reliable marker in predicting 30-day mortality in patients undergoing TAVR. 2022 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398971282003 https://www.redalyc.org/journal/3989/398971282003/ https://www.redalyc.org/journal/3989/398971282003/html/ https://www.redalyc.org/journal/3989/398971282003/398971282003.epub https://www.redalyc.org/journal/3989/398971282003/movil 10.21470/1678-9741-2020-0482 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.3 Vol.37 |
| title | C-Reactive Protein to Albumin Ratio as A Novel Inflammatory-Based Marker for 30-Day Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement |
| topic | Medicina Mortality Serum Albumin Aortic Stenosis Reactive Protein Transcatheter Aortic Valve Replacement |
| url | https://www.redalyc.org/articulo.oa?id=398971282003 https://www.redalyc.org/journal/3989/398971282003/ https://www.redalyc.org/journal/3989/398971282003/html/ https://www.redalyc.org/journal/3989/398971282003/398971282003.epub https://www.redalyc.org/journal/3989/398971282003/movil |