Long Noncoding RNA AF131217.1 Regulated Coronary Slow Flow-Induced Inflammation Affecting Coronary Slow Flow via KLF4
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| Format: | Artículo científico |
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Sociedade Brasileira de Cirurgia Cardiovascular
2022
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| _version_ | 1876432954054410240 |
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| author | Haibing Jiang |
| author_facet | Haibing Jiang |
| contents | Long Noncoding RNA AF131217.1 Regulated Coronary Slow Flow-Induced Inflammation Affecting Coronary Slow Flow via KLF4 Haibing Jiang Zhengrong Ge Lijing Zhang Yi Yang Xueqin Zhai Zhanxi Chen Qing Wei Medicina 18 RNA MicroRNAs Interleukin Inflammation IntroductionThis study investigated the correlation between the levels of long noncoding ribonucleic acids (lncRNAs) AF131217.1 and coronary slow flow (CSF).MethodsA total of 22 patients in the high-sensitivity C-reactive protein (hsCRP) group diagnosed with CSF from January 2018 to December 2018 were enrolled in this study. Coronary flow velocity was determined using the thrombolysis in myocardial infarction frame count (TFC) method. Results: LncRNA AF131217.1 expression in the CSF model was activated. Mean TFC was positively correlated with lncRNA AF131217.1 levels and hsCRP levels. LncRNA AF131217.1 induced inflammation factor levels in the in vitro model. Micro ribonucleic acid (miR)-128-3p is a target spot of lncRNA AF131217.1 on the inflammation in vitro model via Kruppel-like factor (KLF) 4. MiR-128-3p reduced inflammation factor levels (tumor necrosis factor alpha, interleukin IL-6, IL-1β, and IL-18). Conclusion: Thus, lncRNA AF131217.1 promoted inflammation in the regulated CSF via KLF4 by miR-128-3p. 2022 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398972448015 https://www.redalyc.org/journal/3989/398972448015/ https://www.redalyc.org/journal/3989/398972448015/html/ https://www.redalyc.org/journal/3989/398972448015/398972448015.epub https://www.redalyc.org/journal/3989/398972448015/movil 10.21470/1678-9741-2020-0573 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.4 Vol.37 |
| format | Artículo científico |
| id | redalyc_398972448015 |
| institution | Redalyc |
| language | en |
| publishDate | 2022 |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| spellingShingle | Long Noncoding RNA AF131217.1 Regulated Coronary Slow Flow-Induced Inflammation Affecting Coronary Slow Flow via KLF4 Haibing Jiang Medicina 18 RNA MicroRNAs Interleukin Inflammation Long Noncoding RNA AF131217.1 Regulated Coronary Slow Flow-Induced Inflammation Affecting Coronary Slow Flow via KLF4 Haibing Jiang Zhengrong Ge Lijing Zhang Yi Yang Xueqin Zhai Zhanxi Chen Qing Wei Medicina 18 RNA MicroRNAs Interleukin Inflammation IntroductionThis study investigated the correlation between the levels of long noncoding ribonucleic acids (lncRNAs) AF131217.1 and coronary slow flow (CSF).MethodsA total of 22 patients in the high-sensitivity C-reactive protein (hsCRP) group diagnosed with CSF from January 2018 to December 2018 were enrolled in this study. Coronary flow velocity was determined using the thrombolysis in myocardial infarction frame count (TFC) method. Results: LncRNA AF131217.1 expression in the CSF model was activated. Mean TFC was positively correlated with lncRNA AF131217.1 levels and hsCRP levels. LncRNA AF131217.1 induced inflammation factor levels in the in vitro model. Micro ribonucleic acid (miR)-128-3p is a target spot of lncRNA AF131217.1 on the inflammation in vitro model via Kruppel-like factor (KLF) 4. MiR-128-3p reduced inflammation factor levels (tumor necrosis factor alpha, interleukin IL-6, IL-1β, and IL-18). Conclusion: Thus, lncRNA AF131217.1 promoted inflammation in the regulated CSF via KLF4 by miR-128-3p. 2022 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398972448015 https://www.redalyc.org/journal/3989/398972448015/ https://www.redalyc.org/journal/3989/398972448015/html/ https://www.redalyc.org/journal/3989/398972448015/398972448015.epub https://www.redalyc.org/journal/3989/398972448015/movil 10.21470/1678-9741-2020-0573 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.4 Vol.37 |
| title | Long Noncoding RNA AF131217.1 Regulated Coronary Slow Flow-Induced Inflammation Affecting Coronary Slow Flow via KLF4 |
| topic | Medicina 18 RNA MicroRNAs Interleukin Inflammation |
| url | https://www.redalyc.org/articulo.oa?id=398972448015 https://www.redalyc.org/journal/3989/398972448015/ https://www.redalyc.org/journal/3989/398972448015/html/ https://www.redalyc.org/journal/3989/398972448015/398972448015.epub https://www.redalyc.org/journal/3989/398972448015/movil |