Retrospective Evaluation of Platelet-Leukocyte Indices and Cardiac Surgical Outcomes in Acyanotic Heart Disease Patients with Pulmonary Hypertension (REPLICA-PH)
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Sociedade Brasileira de Cirurgia Cardiovascular
2022
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| author | Ashish Walian |
| author_facet | Ashish Walian |
| contents | Retrospective Evaluation of Platelet-Leukocyte Indices and Cardiac Surgical Outcomes in Acyanotic Heart Disease Patients with Pulmonary Hypertension (REPLICA-PH) Ashish Walian Jasvinder Kaur Kohli Rohan Magoon Ramesh Chand Kashav ItiShri . Souvik Dey Narender Singh Jhajhria Medicina Low Platelet Congenital Neutrophil Lymphocyte Introduction: Acyanotic congenital heart disease (ACHD) patients with pulmonary hypertension (PH) are prone to postoperative complications, and characterization of the risk profile continues to fail in identifying inflammatory predilection. Our objective is to investigate the role of platelet-leukocyte indices (neutrophil-lymphocyte ratio NLR, platelet-lymphocyte ratio PLR, and systemic immune-inflammation index SII neutrophil × platelet/lymphocyte) in predicting poor outcomes following cardiac surgery in ACHD cohort with preoperative PH.Methods: This single-center, retrospective risk-predictive study included ACHD patients undergoing surgical correction at our tertiary cardiac center between January 2015 and December 2019. Standard institutional perioperative management protocol was followed, and poor postoperative outcome was defined as ≥ 1 of: low cardiac output syndrome, new-onset renal failure, prolonged mechanical ventilation (MV > 24 hours), stroke, sepsis, and/or death.Results: One hundred eighty patients out of 1,040 (17.3%) presented poor outcome. On univariate analysis, preoperative factors including right ventricular systolic pressure (RVSP) (PH-severity marker), congestive heart failure, albumin, NLR, PLR, SII, and aortic cross-clamping (ACC) and cardiopulmonary bypass (CPB) times predicted poor outcome. However, on multivariate analysis, RVSP, NLR, SII, and ACC and CPB times emerged as independent predictors. An NLR, SII prognostic cutoff of 3.33 and 860.6×103/mm3 was derived (sensitivity: 77.8%, 78.9%; specificity: 91.7%, 82.2%; area under the curve: 0.871, 0.833). NLR and SII values significantly correlated with postoperative MV duration, mean vasoactive-inotropic scores, and length of intensive care unit and hospital stay (P<0.001).Conclusion: Novel parsimonious, reproducible plateletleukocyte indices present the potential of stratifying the risk in congenital cardiac surgical patients with pre-existing PH. 2022 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398973636012 https://www.redalyc.org/journal/3989/398973636012/ https://www.redalyc.org/journal/3989/398973636012/html/ https://www.redalyc.org/journal/3989/398973636012/398973636012.epub https://www.redalyc.org/journal/3989/398973636012/movil 10.21470/1678-9741-2020-0648 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.6 Vol.37 |
| format | Artículo científico |
| id | redalyc_398973636012 |
| institution | Redalyc |
| language | en |
| publishDate | 2022 |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| spellingShingle | Retrospective Evaluation of Platelet-Leukocyte Indices and Cardiac Surgical Outcomes in Acyanotic Heart Disease Patients with Pulmonary Hypertension (REPLICA-PH) Ashish Walian Medicina Low Platelet Congenital Neutrophil Lymphocyte Retrospective Evaluation of Platelet-Leukocyte Indices and Cardiac Surgical Outcomes in Acyanotic Heart Disease Patients with Pulmonary Hypertension (REPLICA-PH) Ashish Walian Jasvinder Kaur Kohli Rohan Magoon Ramesh Chand Kashav ItiShri . Souvik Dey Narender Singh Jhajhria Medicina Low Platelet Congenital Neutrophil Lymphocyte Introduction: Acyanotic congenital heart disease (ACHD) patients with pulmonary hypertension (PH) are prone to postoperative complications, and characterization of the risk profile continues to fail in identifying inflammatory predilection. Our objective is to investigate the role of platelet-leukocyte indices (neutrophil-lymphocyte ratio NLR, platelet-lymphocyte ratio PLR, and systemic immune-inflammation index SII neutrophil × platelet/lymphocyte) in predicting poor outcomes following cardiac surgery in ACHD cohort with preoperative PH.Methods: This single-center, retrospective risk-predictive study included ACHD patients undergoing surgical correction at our tertiary cardiac center between January 2015 and December 2019. Standard institutional perioperative management protocol was followed, and poor postoperative outcome was defined as ≥ 1 of: low cardiac output syndrome, new-onset renal failure, prolonged mechanical ventilation (MV > 24 hours), stroke, sepsis, and/or death.Results: One hundred eighty patients out of 1,040 (17.3%) presented poor outcome. On univariate analysis, preoperative factors including right ventricular systolic pressure (RVSP) (PH-severity marker), congestive heart failure, albumin, NLR, PLR, SII, and aortic cross-clamping (ACC) and cardiopulmonary bypass (CPB) times predicted poor outcome. However, on multivariate analysis, RVSP, NLR, SII, and ACC and CPB times emerged as independent predictors. An NLR, SII prognostic cutoff of 3.33 and 860.6×103/mm3 was derived (sensitivity: 77.8%, 78.9%; specificity: 91.7%, 82.2%; area under the curve: 0.871, 0.833). NLR and SII values significantly correlated with postoperative MV duration, mean vasoactive-inotropic scores, and length of intensive care unit and hospital stay (P<0.001).Conclusion: Novel parsimonious, reproducible plateletleukocyte indices present the potential of stratifying the risk in congenital cardiac surgical patients with pre-existing PH. 2022 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398973636012 https://www.redalyc.org/journal/3989/398973636012/ https://www.redalyc.org/journal/3989/398973636012/html/ https://www.redalyc.org/journal/3989/398973636012/398973636012.epub https://www.redalyc.org/journal/3989/398973636012/movil 10.21470/1678-9741-2020-0648 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.6 Vol.37 |
| title | Retrospective Evaluation of Platelet-Leukocyte Indices and Cardiac Surgical Outcomes in Acyanotic Heart Disease Patients with Pulmonary Hypertension (REPLICA-PH) |
| topic | Medicina Low Platelet Congenital Neutrophil Lymphocyte |
| url | https://www.redalyc.org/articulo.oa?id=398973636012 https://www.redalyc.org/journal/3989/398973636012/ https://www.redalyc.org/journal/3989/398973636012/html/ https://www.redalyc.org/journal/3989/398973636012/398973636012.epub https://www.redalyc.org/journal/3989/398973636012/movil |