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| Format: | Artículo científico |
| Language: | en |
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Sociedade Brasileira de Cirurgia Cardiovascular
2023
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| Online Access: | https://www.redalyc.org/articulo.oa?id=398974859014 https://www.redalyc.org/journal/3989/398974859014/ https://www.redalyc.org/journal/3989/398974859014/html/ https://www.redalyc.org/journal/3989/398974859014/398974859014.epub https://www.redalyc.org/journal/3989/398974859014/movil |
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Table of Contents:
- Reduced Angiopoietin Factor 2 Levels Are Correlated with Better Cardiac Function and Prognosis in Valvular Heart Disease Jian Hou Xiaolin Huang Liqun Shang Guangxian Chen Huawei Wu Zhongkai Wu Suiqing Huang Medicina cytokines inflammation angiopoietin 1 angiopoietin 2 heart Valve Diseases Introduction: There are few circulating biomarkers for valvular heart disease. Angiopoietin (Ang) 1, Ang2, and vascular endothelial growth factor are important inflammation-associated cytokines. The aim of this study was to investigate the clinical significance and association of Ang1, Ang2, and vascular endothelial growth factor in valvular heart disease. Methods: This is a retrospective study; a total of 62 individuals (valvular heart disease patients [n=42] and healthy controls [n=20]) were included. Plasma levels of Ang1, Ang2, and vascular endothelial growth factor were detected by enzyme-linked immunosorbent assays. We retrospectively collected the baseline characteristics and short-term outcomes; logistic regression was performed to identify predictor for short-term mortality. Results: Ang2 was significantly decreased in the valvular heart disease group compared with the healthy control group (P=0.023), while no significant difference was observed in the Ang1 and vascular endothelial growth factor levels. The Ang2 level of New York Heart Association (NYHA) I/II patients — but not NYHA III/IV patients — was significantly decreased compared with that of healthy control individuals (NYHA I/II: P=0.017; NYHA III/IV: P=0.485). Univariable logistic regression analysis indicated that Ang2 was a significant independent predictor for short-term mortality (odds ratio 18.75, P=0.033, 95% confidence interval 8.08–102.33). Ang1 was negatively correlated with Ang2 (P=0.032, Pearson’s correlation coefficient = -0.317) and was positively correlated with vascular endothelial growth factor (P=0.019, Pearson’s correlation coefficient = 0.359). Conclusion: Ang2 might serve as a therapeutic and prognostic target for valvular heart disease. 2023 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398974859014 https://www.redalyc.org/journal/3989/398974859014/ https://www.redalyc.org/journal/3989/398974859014/html/ https://www.redalyc.org/journal/3989/398974859014/398974859014.epub https://www.redalyc.org/journal/3989/398974859014/movil 10.21470/1678-9741-2021-0364 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.1 Vol.38