Severe and Moderate Primary Graft Dysfunction in Adult Heart Recipients
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| Natura: | Artículo científico |
| Lingua: | en |
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Sociedade Brasileira de Cirurgia Cardiovascular
2023
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| _version_ | 1876438561304084480 |
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| author | Samuel Padovani Stefen |
| author_facet | Samuel Padovani Stefen |
| contents | Severe and Moderate Primary Graft Dysfunction in Adult Heart Recipients Samuel Padovani Stefen Davi Freitas Tenório Guilherme Carvalhal Gnipper Cirillo Shirlyne Fabianni Gaspar Karen Amanda Soares de Oliveira Fábio Antonio Gaiotto Fabio B. Jatene Medicina Risk Factors Tissue Donors Heart Transplantation Primary Graft Dysfunction Cardiopulmonary Resuscitation Introduction: The aims of this study were to determine the incidence of severe and moderate primary graft dysfunction (PGD) in our center, to identify, retrospectively, donors’ and recipients’ risk factors for PGD development, and to evaluate the impact of PGD within 30 days after heart transplantation.Methods: Donors’ and recipients’ medical records of 64 consecutive adult cardiac transplantations performed between January 2016 and June 2017 were reviewed. The International Society for Heart and Lung Transplantation (ISHLT) criteria were used to diagnose moderate and severe PGD. Associations of risk factors for combined moderate/severe PGD were assessed with appropriate statistical analyses.Results: Sixty-four patients underwent heart transplantation in this period. Twelve recipients (18.7%) developed severe or moderate PGD. Development of PGD was associated with previous donor cardiopulmonary resuscitation and a history of prior heart surgery in the recipient (P=0.01 and P=0.02, respectively). The 30-day in hospital mortality was similar in both PGD and non-PGD patients.Conclusion: The use of the ISHLT criteria for PGD is important to identify potential risk factor. The development of PGD did not affect short-term survival in our study. More studies should be done to better understand the pathophysiology of PGD. 2023 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398974952002 https://www.redalyc.org/journal/3989/398974952002/ https://www.redalyc.org/journal/3989/398974952002/html/ https://www.redalyc.org/journal/3989/398974952002/398974952002.epub https://www.redalyc.org/journal/3989/398974952002/movil 10.21470/1678-9741-2022-0107 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.2 Vol.38 |
| format | Artículo científico |
| id | redalyc_398974952002 |
| institution | Redalyc |
| language | en |
| publishDate | 2023 |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| spellingShingle | Severe and Moderate Primary Graft Dysfunction in Adult Heart Recipients Samuel Padovani Stefen Medicina Risk Factors Tissue Donors Heart Transplantation Primary Graft Dysfunction Cardiopulmonary Resuscitation Severe and Moderate Primary Graft Dysfunction in Adult Heart Recipients Samuel Padovani Stefen Davi Freitas Tenório Guilherme Carvalhal Gnipper Cirillo Shirlyne Fabianni Gaspar Karen Amanda Soares de Oliveira Fábio Antonio Gaiotto Fabio B. Jatene Medicina Risk Factors Tissue Donors Heart Transplantation Primary Graft Dysfunction Cardiopulmonary Resuscitation Introduction: The aims of this study were to determine the incidence of severe and moderate primary graft dysfunction (PGD) in our center, to identify, retrospectively, donors’ and recipients’ risk factors for PGD development, and to evaluate the impact of PGD within 30 days after heart transplantation.Methods: Donors’ and recipients’ medical records of 64 consecutive adult cardiac transplantations performed between January 2016 and June 2017 were reviewed. The International Society for Heart and Lung Transplantation (ISHLT) criteria were used to diagnose moderate and severe PGD. Associations of risk factors for combined moderate/severe PGD were assessed with appropriate statistical analyses.Results: Sixty-four patients underwent heart transplantation in this period. Twelve recipients (18.7%) developed severe or moderate PGD. Development of PGD was associated with previous donor cardiopulmonary resuscitation and a history of prior heart surgery in the recipient (P=0.01 and P=0.02, respectively). The 30-day in hospital mortality was similar in both PGD and non-PGD patients.Conclusion: The use of the ISHLT criteria for PGD is important to identify potential risk factor. The development of PGD did not affect short-term survival in our study. More studies should be done to better understand the pathophysiology of PGD. 2023 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398974952002 https://www.redalyc.org/journal/3989/398974952002/ https://www.redalyc.org/journal/3989/398974952002/html/ https://www.redalyc.org/journal/3989/398974952002/398974952002.epub https://www.redalyc.org/journal/3989/398974952002/movil 10.21470/1678-9741-2022-0107 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.2 Vol.38 |
| title | Severe and Moderate Primary Graft Dysfunction in Adult Heart Recipients |
| topic | Medicina Risk Factors Tissue Donors Heart Transplantation Primary Graft Dysfunction Cardiopulmonary Resuscitation |
| url | https://www.redalyc.org/articulo.oa?id=398974952002 https://www.redalyc.org/journal/3989/398974952002/ https://www.redalyc.org/journal/3989/398974952002/html/ https://www.redalyc.org/journal/3989/398974952002/398974952002.epub https://www.redalyc.org/journal/3989/398974952002/movil |