Efficacy and Safety Profile of Low-Dose Tranexamic Acid Regimen in Cardiac Surgery: A Meta-Analysis
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Sociedade Brasileira de Cirurgia Cardiovascular
2025
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| author | Ardyan Wardhana |
| author_facet | Ardyan Wardhana |
| contents | Efficacy and Safety Profile of Low-Dose Tranexamic Acid Regimen in Cardiac Surgery: A Meta-Analysis Ardyan Wardhana Cornelia Ghea Alfredo Nugroho Nathania Christi Putri Kinasih Johanes Nugroho Medicina Meta Analysis hemorrhage Tranexamic Acid thoracic Surgery Various dosing regimens of tranexamic acid have been reported to exhibit varying efficacy and safety profiles. Herein, we conducted a meta-analysis to evaluate the efficacy and safety of low-dose regimens in open-heart surgery. Methods: Three databases were systematically searched for randomized trials examining the bleeding reduction effect of tranexamic acid in open-heart surgery. The pooled data of the low-dose group was then compared with the control, high-dose, and epsilon aminocaproic acid groups. The boundary between the low- and high-dose groups was a bolus of 30 mg/kg followed by 16 mg/kg/hour. Results: The meta-analysis included 81 studies. The low-dose tranexamic acid regimen was associated with a decreased incidence of reoperation (risk ratio: 0.52; 95% confidence interval: 0.39–0.69; high quality of evidence), perioperative myocardial infarction (risk ratio: 0.64; 95% confidence interval: 0.43–0.95; high. 2025 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398982402004 https://www.redalyc.org/journal/3989/398982402004/ https://www.redalyc.org/journal/3989/398982402004/html/ https://www.redalyc.org/journal/3989/398982402004/398982402004.epub https://www.redalyc.org/journal/3989/398982402004/movil 10.21470/1678-9741-2024-0022 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.5 Vol.40 |
| format | Artículo científico |
| id | redalyc_398982402004 |
| institution | Redalyc |
| language | en |
| publishDate | 2025 |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| spellingShingle | Efficacy and Safety Profile of Low-Dose Tranexamic Acid Regimen in Cardiac Surgery: A Meta-Analysis Ardyan Wardhana Medicina Meta Analysis hemorrhage Tranexamic Acid thoracic Surgery Efficacy and Safety Profile of Low-Dose Tranexamic Acid Regimen in Cardiac Surgery: A Meta-Analysis Ardyan Wardhana Cornelia Ghea Alfredo Nugroho Nathania Christi Putri Kinasih Johanes Nugroho Medicina Meta Analysis hemorrhage Tranexamic Acid thoracic Surgery Various dosing regimens of tranexamic acid have been reported to exhibit varying efficacy and safety profiles. Herein, we conducted a meta-analysis to evaluate the efficacy and safety of low-dose regimens in open-heart surgery. Methods: Three databases were systematically searched for randomized trials examining the bleeding reduction effect of tranexamic acid in open-heart surgery. The pooled data of the low-dose group was then compared with the control, high-dose, and epsilon aminocaproic acid groups. The boundary between the low- and high-dose groups was a bolus of 30 mg/kg followed by 16 mg/kg/hour. Results: The meta-analysis included 81 studies. The low-dose tranexamic acid regimen was associated with a decreased incidence of reoperation (risk ratio: 0.52; 95% confidence interval: 0.39–0.69; high quality of evidence), perioperative myocardial infarction (risk ratio: 0.64; 95% confidence interval: 0.43–0.95; high. 2025 artículo científico 0102-7638 https://www.redalyc.org/articulo.oa?id=398982402004 https://www.redalyc.org/journal/3989/398982402004/ https://www.redalyc.org/journal/3989/398982402004/html/ https://www.redalyc.org/journal/3989/398982402004/398982402004.epub https://www.redalyc.org/journal/3989/398982402004/movil 10.21470/1678-9741-2024-0022 en http://www.redalyc.org/revista.oa?id=3989 Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery application/pdf Sociedade Brasileira de Cirurgia Cardiovascular Revista Brasileira de Cirurgia Cardiovascular/Brazilian Journal of Cardiovascular Surgery (Brasil) Num.5 Vol.40 |
| title | Efficacy and Safety Profile of Low-Dose Tranexamic Acid Regimen in Cardiac Surgery: A Meta-Analysis |
| topic | Medicina Meta Analysis hemorrhage Tranexamic Acid thoracic Surgery |
| url | https://www.redalyc.org/articulo.oa?id=398982402004 https://www.redalyc.org/journal/3989/398982402004/ https://www.redalyc.org/journal/3989/398982402004/html/ https://www.redalyc.org/journal/3989/398982402004/398982402004.epub https://www.redalyc.org/journal/3989/398982402004/movil |