Effect of oseltamivir and some vitamins on Dopamine, GSH and Lipid Peroxidation levels in young animal models exposed to O3
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Universidad de Guanajuato
2015
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| _version_ | 1876465243452866560 |
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| author | David Calderón Guzmán |
| author_facet | David Calderón Guzmán |
| contents | Effect of oseltamivir and some vitamins on Dopamine, GSH and Lipid Peroxidation levels in young animal models exposed to O3 David Calderón Guzmán Jonas Attilus Hugo Juárez Olguín Ernestina Hernández García Norma Osnaya Brizuela Maribel Ortiz Herrera Gerardo Barragán Mejía Multidisciplinarias (Ciencias Sociales) ozone Oseltamivir glutathione lipoperoxidation Oseltamivir is used for the treatment of AH1N1 swine influenza in Mexico. The aim of the present study was to analyze the effect of oseltamivir on dopamine levels in patients ex-posed to vitamins A, D, and C as well as to ozone. For this, forty male Wistar rats (80 g) were divided into 6 groups. A combination of oseltamivir (20 vmg/kg) with A (39 v0UI.), C (30 mg) and D (60 UI.) vitamins with or without ozone 0.5 ppm were intraperitoneally administered for 5 days. The exposition to ozone was through a camera controlled. The animals were sacrificed and the brain dissected in cortex (I), hemispheres (II) and cerebellum/medulla oblongata (III) to measure dopamine, glutathione (GSH) and lipoperoxidation using fluo-rescence. Dopamine increased in I, II and III regions while GSH increased only in II and III regions and lipoperoxidation decreased in the same regions. This changes were significant (p < 0.05) in the groups that received oseltamivir and ozone. Administration of oseltamivir and ozone induces synergic effect on dopamine metabolism. 2015 artículo científico 0188-6266 https://www.redalyc.org/articulo.oa?id=41641037005 en http://www.redalyc.org/revista.oa?id=416 Acta Universitaria application/pdf Universidad de Guanajuato Acta Universitaria (México) Num.1 Vol.25 |
| format | Artículo científico |
| id | redalyc_41641037005 |
| institution | Redalyc |
| language | en |
| publishDate | 2015 |
| publisher | Universidad de Guanajuato |
| spellingShingle | Effect of oseltamivir and some vitamins on Dopamine, GSH and Lipid Peroxidation levels in young animal models exposed to O3 David Calderón Guzmán Multidisciplinarias (Ciencias Sociales) ozone Oseltamivir glutathione lipoperoxidation Effect of oseltamivir and some vitamins on Dopamine, GSH and Lipid Peroxidation levels in young animal models exposed to O3 David Calderón Guzmán Jonas Attilus Hugo Juárez Olguín Ernestina Hernández García Norma Osnaya Brizuela Maribel Ortiz Herrera Gerardo Barragán Mejía Multidisciplinarias (Ciencias Sociales) ozone Oseltamivir glutathione lipoperoxidation Oseltamivir is used for the treatment of AH1N1 swine influenza in Mexico. The aim of the present study was to analyze the effect of oseltamivir on dopamine levels in patients ex-posed to vitamins A, D, and C as well as to ozone. For this, forty male Wistar rats (80 g) were divided into 6 groups. A combination of oseltamivir (20 vmg/kg) with A (39 v0UI.), C (30 mg) and D (60 UI.) vitamins with or without ozone 0.5 ppm were intraperitoneally administered for 5 days. The exposition to ozone was through a camera controlled. The animals were sacrificed and the brain dissected in cortex (I), hemispheres (II) and cerebellum/medulla oblongata (III) to measure dopamine, glutathione (GSH) and lipoperoxidation using fluo-rescence. Dopamine increased in I, II and III regions while GSH increased only in II and III regions and lipoperoxidation decreased in the same regions. This changes were significant (p < 0.05) in the groups that received oseltamivir and ozone. Administration of oseltamivir and ozone induces synergic effect on dopamine metabolism. 2015 artículo científico 0188-6266 https://www.redalyc.org/articulo.oa?id=41641037005 en http://www.redalyc.org/revista.oa?id=416 Acta Universitaria application/pdf Universidad de Guanajuato Acta Universitaria (México) Num.1 Vol.25 |
| title | Effect of oseltamivir and some vitamins on Dopamine, GSH and Lipid Peroxidation levels in young animal models exposed to O3 |
| topic | Multidisciplinarias (Ciencias Sociales) ozone Oseltamivir glutathione lipoperoxidation |
| url | https://www.redalyc.org/articulo.oa?id=41641037005 |