Dengue-yellow fever sera cross-reactivity; challenges for diagnosis
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| Format: | Artículo científico |
| Langue: | en |
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Universidad Nacional de Colombia
2008
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| _version_ | 1876482805656977408 |
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| author | Natalia Houghton-Triviño |
| author_facet | Natalia Houghton-Triviño |
| contents | Dengue-yellow fever sera cross-reactivity; challenges for diagnosis Natalia Houghton-Triviño Diana Montaña Jaime E. Castellanos Salud NLM) Dengue flavivirus yellow fever differential diagnosis (source: MeSH Objective The Flavivirus genera share epitopes inducing cross-reactive antibodies leading to great difficulty in differentially diagnosing flaviviral infections. This work was aimed at evaluating the complexity of dengue and yellow fever serological differential diagnosis. Material and methods Dengue antibody capture ELISA and a yellow fever neutralisation test were carried out on 13 serum samples obtained from yellow fever patients, 20 acute serum samples from dengue patients and 19 voluntary serum samples pre- and post-vaccination with YF vaccine. Results Dengue ELISA revealed IgM reactivity in 46,2 % of yellow fever patients and 42 % of vaccinees. Sixteen out of 20 dengue patients (80 %) had high YF virus neutralisation titres. Conclusions. Such very high cross-reactivity data challenged differential laboratory diagnosis of dengue and yellow fever in areas where both flaviviruses co-circulate. New laboratory strategies are thus needed for improving the tests and providing a specific laboratory diagnosis. Cross-reactivity between Flaviviruses represents a great difficulty for epidemiological surveillance and preventing dengue, both of which demand urgent attention. 2008 artículo científico 0124-0064 https://www.redalyc.org/articulo.oa?id=42210210 en http://www.redalyc.org/revista.oa?id=422 Revista de Salud Pública application/pdf Universidad Nacional de Colombia Revista de Salud Pública (Colombia) Num.2 Vol.10 |
| format | Artículo científico |
| id | redalyc_42210210 |
| institution | Redalyc |
| language | en |
| publishDate | 2008 |
| publisher | Universidad Nacional de Colombia |
| spellingShingle | Dengue-yellow fever sera cross-reactivity; challenges for diagnosis Natalia Houghton-Triviño Salud NLM) Dengue flavivirus yellow fever differential diagnosis (source: MeSH Dengue-yellow fever sera cross-reactivity; challenges for diagnosis Natalia Houghton-Triviño Diana Montaña Jaime E. Castellanos Salud NLM) Dengue flavivirus yellow fever differential diagnosis (source: MeSH Objective The Flavivirus genera share epitopes inducing cross-reactive antibodies leading to great difficulty in differentially diagnosing flaviviral infections. This work was aimed at evaluating the complexity of dengue and yellow fever serological differential diagnosis. Material and methods Dengue antibody capture ELISA and a yellow fever neutralisation test were carried out on 13 serum samples obtained from yellow fever patients, 20 acute serum samples from dengue patients and 19 voluntary serum samples pre- and post-vaccination with YF vaccine. Results Dengue ELISA revealed IgM reactivity in 46,2 % of yellow fever patients and 42 % of vaccinees. Sixteen out of 20 dengue patients (80 %) had high YF virus neutralisation titres. Conclusions. Such very high cross-reactivity data challenged differential laboratory diagnosis of dengue and yellow fever in areas where both flaviviruses co-circulate. New laboratory strategies are thus needed for improving the tests and providing a specific laboratory diagnosis. Cross-reactivity between Flaviviruses represents a great difficulty for epidemiological surveillance and preventing dengue, both of which demand urgent attention. 2008 artículo científico 0124-0064 https://www.redalyc.org/articulo.oa?id=42210210 en http://www.redalyc.org/revista.oa?id=422 Revista de Salud Pública application/pdf Universidad Nacional de Colombia Revista de Salud Pública (Colombia) Num.2 Vol.10 |
| title | Dengue-yellow fever sera cross-reactivity; challenges for diagnosis |
| topic | Salud NLM) Dengue flavivirus yellow fever differential diagnosis (source: MeSH |
| url | https://www.redalyc.org/articulo.oa?id=42210210 |